Peptide GPCRs (WP24)

Homo sapiens

Open in new tab Open in NDEx Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. [https://en.wikipedia.org/wiki/G_protein%E2%80%93coupled_receptor Wikipedia] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP24 CPTAC Assay Portal]

Authors

Nathan Salomonis , Alex Pico , Kristina Hanspers , Martina Summer-Kutmon , Egon Willighagen , Zahra Roudbari , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

G protein mediated signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Oxytocin Metabolite cas:50-56-6
Bradykinin Metabolite hmdb:HMDB0004246
SSTR2 GeneProduct ncbigene:6752
IL8RA GeneProduct ncbigene:3577
NPY2R GeneProduct ncbigene:4887
CXCR3 GeneProduct ncbigene:2833
CCR5 GeneProduct ncbigene:1234
GALR3 GeneProduct ncbigene:8484
TACR1 GeneProduct ncbigene:6869
BDKRB2 GeneProduct ncbigene:624
FPR1 GeneProduct ncbigene:2357
AGTR2 GeneProduct ncbigene:186
NMBR GeneProduct ncbigene:4829
AVPR2 GeneProduct ncbigene:554
TAC4 GeneProduct ncbigene:255061
BLR1 GeneProduct ncbigene:643
AGTR1 GeneProduct ncbigene:185
SSTR4 GeneProduct ncbigene:6754
BDKRB1 GeneProduct ncbigene:623
NTSR2 GeneProduct ncbigene:23620 CAA71233 - human AA#
CXCR4 GeneProduct ncbigene:7852
NPY5R GeneProduct ncbigene:4889
CCR7 GeneProduct ncbigene:1236
FPRL1 GeneProduct ncbigene:2358
ATP8A1 GeneProduct ncbigene:10396
FPRL2 GeneProduct ncbigene:2359
OPRM1 GeneProduct ncbigene:4988
AVPR1A GeneProduct ncbigene:552
GALR1 GeneProduct ncbigene:2587
CCKAR GeneProduct ncbigene:886
MC3R GeneProduct ncbigene:4159
LHCGR GeneProduct ncbigene:3973
CCKBR GeneProduct ncbigene:887
EDNRA GeneProduct ncbigene:1909
CX3CR1 GeneProduct ncbigene:1524
GHSR GeneProduct ncbigene:2693
CCR8 GeneProduct ncbigene:1237
CCR-9 GeneProduct ncbigene:10803
SSTR3 GeneProduct ncbigene:6753
GRPR GeneProduct ncbigene:2925
EDNRB GeneProduct ncbigene:1910
MC4R GeneProduct ncbigene:4160
FSHR GeneProduct ncbigene:2492
TSHR GeneProduct ncbigene:7253
TACR3 GeneProduct ncbigene:6870
GNRHR GeneProduct ncbigene:2798
BRS3 GeneProduct ncbigene:680
TRHR GeneProduct ncbigene:7201
AVPR1B GeneProduct ncbigene:553
CXCR6 GeneProduct ncbigene:10663
MC2R GeneProduct ncbigene:4158
NPY1R GeneProduct ncbigene:4886
SSTR5 GeneProduct ncbigene:6755
TACR2 GeneProduct ncbigene:6865
MC5R GeneProduct ncbigene:4161
MC1R GeneProduct ncbigene:4157
PPYR1 GeneProduct ncbigene:5540
CCR2 GeneProduct ncbigene:729230
OXTR GeneProduct ncbigene:5021
OPRK1 GeneProduct ncbigene:4986
CCR1 GeneProduct ncbigene:1230
SSTR1 GeneProduct ncbigene:6751
NTSR1 GeneProduct ncbigene:4923
GALR2 GeneProduct ncbigene:8811
IL8RB GeneProduct ncbigene:3579
OPRD1 GeneProduct ncbigene:4985
OPRL1 GeneProduct ncbigene:4987
CCR10 GeneProduct ncbigene:2826
NPY6R GeneProduct ncbigene:4888 human Acc# BAA13103
C3AR1 GeneProduct ncbigene:719
C5R1 GeneProduct ncbigene:728
CCR3 GeneProduct ncbigene:1232
FY GeneProduct ncbigene:2532
CCR4 GeneProduct ncbigene:1233
CCR6 GeneProduct ncbigene:1235
HCRTR1 GeneProduct ncbigene:3061
HCRTR2 GeneProduct ensembl:ENSG00000137252 CAA71233 - human AA#

References

  1. G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells. Kukkonen JP. Biochem Biophys Res Commun. 2016 Aug 5;476(4):379–85. PubMed Europe PMC Scholia