Iron metabolism in placenta (WP2007)

Homo sapiens

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During pregnancy, iron is transported from mother to fetus across the placenta. Iron is essential for many biological processes, including the transfer of oxygen in blood, but it can also be toxic. Elaborate and elegant mechanisms have evolved to make sure that the potential for oxidative damage is minimized. This description of Iron pathway through the placenta, and its regulation is purposed to understand the effect of Iron deficiency or Iron overload of the mother on the fetus. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2007 CPTAC Assay Portal]

Authors

Jerome Compain , Kristina Hanspers , Martijn Van Iersel , Chris Evelo , Daniela Digles , Egon Willighagen , and Andika Tan

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Micronutrients

Annotations

Pathway Ontology

iron transport pathway iron homeostasis pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
FeII Metabolite cas:15438-31-0
FeIII Metabolite cas:20074-52-6
SLC40A1 GeneProduct ensembl:ENSG00000138449
IREB2 GeneProduct ensembl:ENSG00000136381
HEPHL1 GeneProduct ensembl:ENSG00000181333
IRP1 GeneProduct ensembl:ENSG00000122729
STEAP3 GeneProduct ensembl:ENSG00000115107
SLC11A2 GeneProduct ensembl:ENSG00000110911
MCOLN1 GeneProduct ensembl:ENSG00000090674
TFR2 GeneProduct ensembl:ENSG00000106327 Transferrin receptor
foetal HAMP? Protein ensembl:ENSG00000105697 HAMP
TF Protein ensembl:ENSG00000091513 Transferrin
HAMP Protein ensembl:ENSG00000105697
TFR1 Protein ensembl:ENSG00000072274 Transferrin receptor
foetal TF Protein ensembl:ENSG00000091513 Transferrin

References

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