Ascorbate and aldarate metabolism (WP1622)

Mycobacterium tuberculosis

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Source: [http://www.genome.jp/kegg-bin/show_pathway?mtu00053 KEGG Pathways]. The Ascorbate and aldarate metabolism for Mycobacterium tuberculosis is not completely understood yet; conversions which are not clear are depicted with a dashed arrow. Two out of the three literature references provided for this pathway are for E. coli and could be not specific enough for Mycobacterium tuberculosis.

Authors

Allan Kuchinsky , Alex Pico , Christine Chichester , Martina Summer-Kutmon , Egon Willighagen , and Denise Slenter

Activity

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Organisms

Mycobacterium tuberculosis

Communities

Annotations

Pathway Ontology

ascorbate and aldarate metabolic pathway glucose conversion pathway

Participants

Label Type Compact URI Comment
L-Gulono-1,4-lactone Metabolite kegg.compound:C01040
D-Glucarate Metabolite kegg.compound:C00818
D-Glucuronolactone Metabolite kegg.compound:C02670
UDP-glucose Metabolite kegg.compound:C00029
UDP-glucuronate Metabolite kegg.compound:C00167
L-Ascorbate Metabolite kegg.compound:C00072
L-xylo-Hexulonolactone Metabolite kegg.compound:C03289
aldA Protein ncbiprotein:NP_215282 Original kegg element: gene;67;mtu:Rv0147 mtu:Rv0458 mtu:Rv0768 mtu:Rv2858c
L-gulonolactone oxidase Protein eccode:1.1.3.8
aldehyde dehydrogenase (EC:1.2.1.3) Protein ncbiprotein:NP_214661 Original kegg element: gene;67;mtu:Rv0147 mtu:Rv0458 mtu:Rv0768 mtu:Rv2858c
aldC Protein ncbiprotein:NP_217374 Original kegg element: gene;67;mtu:Rv0147 mtu:Rv0458 mtu:Rv0768 mtu:Rv2858c
aldehyde dehydrogenase (EC:1.2.1.-) Protein ncbiprotein:NP_214737 Original kegg element: gene;67;mtu:Rv0147 mtu:Rv0458 mtu:Rv0768 mtu:Rv2858c
udgA Protein eccode:1.1.1.22 Original kegg element: gene;15;mtu:Rv0322

References

  1. The ascorbate transporter of Escherichia coli. Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr. J Bacteriol. 2003 Apr;185(7):2243–50. PubMed Europe PMC Scholia
  2. Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli. Campos E, Baldoma L, Aguilar J, Badia J. J Bacteriol. 2004 Mar;186(6):1720–8. PubMed Europe PMC Scholia
  3. Comparative analyses of nonpathogenic, opportunistic, and totally pathogenic mycobacteria reveal genomic and biochemical variabilities and highlight the survival attributes of Mycobacterium tuberculosis. Rahman SA, Singh Y, Kohli S, Ahmad J, Ehtesham NZ, Tyagi AK, et al. mBio. 2014 Nov 4;5(6):e02020. PubMed Europe PMC Scholia