Intracellular trafficking of CFTR (WP1486)

Rattus norvegicus

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This pathway describes the mechanism of endo- and exocytosis of CFTR channel, based on the article: "New insights into cystic fibrosis: molecular switches that regulate CFTR" by Guggino et al. 2006. On the left side (in red) the endocytic mechanism is shown. Respectively in green on the right sight the exocytic mechanism. We integrated the functions of PDZ proteins, SNAREs and Rho GTPases.

Authors

Thomas Theelen , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Friederike Ehrhart

Activity

last edited

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

protein transport pathway

Participants

Label Type Compact URI Comment
Cftr GeneProduct ensembl:ENSRNOG00000055103
Ezrin GeneProduct ensembl:ENSRNOG00000018524
Slc9a3r1 GeneProduct ensembl:ENSRNOG00000003232
Rab7 GeneProduct ensembl:ENSRNOG00000012247
Cal GeneProduct ensembl:ENSRNOG00000011774
Rab11a GeneProduct ensembl:ENSRNOG00000011302
Myo6 GeneProduct ensembl:ENSRNOG00000011852
Myosin-VI GeneProduct ensembl:ENSRNOG00000011852
Tc10 GeneProduct ensembl:ENSRNOG00000015415
Cftr Protein ensembl:ENSRNOG00000055103
Slc9a3r1 Protein ensembl:ENSRNOG00000003232
Rab9 Protein ensembl:ENSRNOG00000030443
Cal Protein ensembl:ENSRNOG00000011774
Rab5a Protein ensembl:ENSRNOG00000057056
Rab11a Protein ensembl:ENSRNOG00000011302

References

  1. Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6. Charest A, Lane K, McMahon K, Housman DE. J Biol Chem. 2001 Aug 3;276(31):29456–65. PubMed Europe PMC Scholia
  2. PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulator. Swiatecka-Urban A, Duhaime M, Coutermarsh B, Karlson KH, Collawn J, Milewski M, et al. J Biol Chem. 2002 Oct 18;277(42):40099–105. PubMed Europe PMC Scholia
  3. Rme-1 regulates the recycling of the cystic fibrosis transmembrane conductance regulator. Picciano JA, Ameen N, Grant BD, Bradbury NA. Am J Physiol Cell Physiol. 2003 Nov;285(5):C1009-18. PubMed Europe PMC Scholia
  4. Endocytic trafficking routes of wild type and DeltaF508 cystic fibrosis transmembrane conductance regulator. Gentzsch M, Chang XB, Cui L, Wu Y, Ozols VV, Choudhury A, et al. Mol Biol Cell. 2004 Jun;15(6):2684–96. PubMed Europe PMC Scholia
  5. The Ras superfamily at a glance. Wennerberg K, Rossman KL, Der CJ. J Cell Sci. 2005 Mar 1;118(Pt 5):843–6. PubMed Europe PMC Scholia
  6. Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator. Cheng J, Cebotaru V, Cebotaru L, Guggino WB. Mol Biol Cell. 2010 Apr 1;21(7):1178–87. PubMed Europe PMC Scholia