Osteopontin signaling (WP1434)
Homo sapiens
Study of regulation of promatrix metalloproteinase-9 (MMP-9) by osteopontin (OPN) through IKK signaling pathway. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1434 CPTAC Assay Portal]
Authors
Luigi Maiorana , Thomas Kelder , Kristina Hanspers , Alex Pico , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric WeitzActivity
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Cited In
- Network-based identification genetic effect of SARS-CoV-2 infections to Idiopathic pulmonary fibrosis (IPF) patients (2020).
- MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity.
- Identification of the Genetic Influence of SARS-CoV-2 Infections on IgA Nephropathy Based on Bioinformatics Method (2023).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
signaling pathway signaling pathway pertinent to development| Label | Type | Compact URI | Comment |
|---|---|---|---|
| RELA | GeneProduct | ncbigene:5970 | |
| IKK-alpha | GeneProduct | ncbigene:1147 | |
| PLAU | GeneProduct | ncbigene:5328 | |
| ERK2 | GeneProduct | ncbigene:5594 | |
| IKK-beta | GeneProduct | ncbigene:3551 | |
| MEK1 | GeneProduct | ncbigene:5604 | |
| NFKB1 | GeneProduct | ncbigene:4790 | |
| NIK | GeneProduct | ncbigene:9020 | |
| ITGAV | GeneProduct | ncbigene:3685 | |
| ITGB3 | GeneProduct | ncbigene:3690 | |
| MMP-9 | GeneProduct | ncbigene:4318 | |
| SPP1 | GeneProduct | ncbigene:6696 | |
| ERK1 | GeneProduct | ncbigene:5595 |
References
- Osteopontin: it’s role in regulation of cell motility and nuclear factor kappa B-mediated urokinase type plasminogen activator expression. Das R, Philip S, Mahabeleshwar GH, Bulbule A, Kundu GC. IUBMB Life. 2005 Jun;57(6):441–7. PubMed Europe PMC Scholia