Calcium regulation in cardiac cells (WP808)

Gallus gallus

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Calcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors. Movement of calcium ions from the extracellular compartment to the intracellular compartment alters membrane depolarisation. This is seen in the heart, during the plateau phase of ventricular contraction. In this example, calcium acts to maintain depolarisation of the heart. Source: [[wikipedia:Calcium_signaling|Wikipedia]]

Authors

Thomas Kelder , Kristina Hanspers , Christine Chichester , Egon Willighagen , Alex Pico , Martina Summer-Kutmon , Lauren J. Dupuis , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Gallus gallus

Communities

Annotations

Disease Ontology

cardiovascular system disease

Pathway Ontology

calcium/calcium-mediated signaling pathway

Cell Type Ontology

cardiac muscle cell

Participants

Label Type Compact URI Comment
ATP Metabolite cas:1927-31-7
Epinephrine Metabolite hmdb:HMDB0000068
Na+ Metabolite hmdb:HMDB0000588
Acetylcholine Metabolite cas:51-84-3
Pi Metabolite hmdb:HMDB0001429
IP4 Metabolite chebi:16783
IP3 Metabolite chemspider:388562
ADP Metabolite cas:58-64-0
K+ Metabolite hmdb:HMDB0000586
Ca2+ Metabolite hmdb:HMDB0000464
cAMP Metabolite pubchem.compound:6076
PIP2 Metabolite hmdb:HMDB0010032
ADP Metabolite hmdb:HMDB0001341
CACNB1 GeneProduct ensembl:ENSGALG00000025788 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:782
CALM GeneProduct ensembl:ENSGALG00000026445 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:801
CAMK2G GeneProduct ensembl:ENSGALG00000005088 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:818
RYR2 GeneProduct ensembl:ENSGALG00000010812 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6262
RGS6 GeneProduct ensembl:ENSGALG00000009368 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9628
GNG2 GeneProduct ensembl:ENSGALG00000027629 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:54331
ADCY1 GeneProduct ensembl:ENSGALG00000031170 CYA1 HUMAN
Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:107
CAMK2A GeneProduct ensembl:ENSGALG00000005621 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:815
PRKCB GeneProduct ensembl:ENSGALG00000037943 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5579
CACNA1E GeneProduct ensembl:ENSGALG00000003833 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:777
GNG13 GeneProduct ensembl:ENSGALG00000038594 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:51764
RGS1 GeneProduct ensembl:ENSGALG00000002549 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5996
ATP2B1 GeneProduct ensembl:ENSGALG00000030550 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:490
GNAI2 GeneProduct ensembl:ENSGALG00000035645 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2771
ATP2A3 GeneProduct ensembl:ENSGALG00000001564 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:489
GJA5 GeneProduct ensembl:ENSGALG00000039452 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2702
ADRA1A GeneProduct ensembl:ENSGALG00000000469 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:148
GNB4 GeneProduct ensembl:ENSGALG00000008983 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:59345
PLN GeneProduct ensembl:ENSGALG00000027583 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5350
RGS20 GeneProduct ensembl:ENSGALG00000025941 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8601
GJA9 GeneProduct ensembl:ENSGALG00000028175 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:81025
CALM GeneProduct ensembl:ENSGALG00000026445 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:805
PRKACB GeneProduct ensembl:ENSGALG00000028530 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5567
RYR1 GeneProduct ensembl:ENSGALG00000029845 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6261
CAMK4 GeneProduct ensembl:ENSGALG00000000244 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:814
ADCY5 GeneProduct ensembl:ENSGALG00000031244 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:111
PKIB GeneProduct ensembl:ENSGALG00000027036 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5570
RGS10 GeneProduct ensembl:ENSGALG00000009422 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6001
ADRA1D GeneProduct ensembl:ENSGALG00000043154 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:146
ADRB1 GeneProduct ensembl:ENSGALG00000008949 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:153
RGS14 GeneProduct ensembl:ENSGALG00000003113 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:10636
CACNA1S GeneProduct ensembl:ENSGALG00000037744 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:779
CHRM4 GeneProduct ensembl:ENSGALG00000008365 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1132
CHRM2 GeneProduct ensembl:ENSGALG00000012894 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1129
CACNA1C GeneProduct ensembl:ENSGALG00000013022 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:775
GJC1 GeneProduct ensembl:ENSGALG00000000997 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:10052
ADCY2 GeneProduct ensembl:ENSGALG00000013060 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:108
GJA1 GeneProduct ensembl:ENSGALG00000014873 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2697
ITPR2 GeneProduct ensembl:ENSGALG00000014071 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3709
PRKAR1B GeneProduct ensembl:ENSGALG00000003675 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5575
CACNA1D GeneProduct ensembl:ENSGALG00000005332 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:776
CAMK2D GeneProduct ensembl:ENSGALG00000041635 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:817
GNB3 GeneProduct ensembl:ENSGALG00000034438 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2784
CACNA1A GeneProduct ensembl:ENSGALG00000037131 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:773
KCNJ3 GeneProduct ensembl:ENSGALG00000012537 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3760
RGS5 GeneProduct ensembl:ENSGALG00000026572 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8490
YWHAB GeneProduct ensembl:ENSGALG00000004143 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7529
GNB5 GeneProduct ensembl:ENSGALG00000039307 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:10681
KCNJ5 GeneProduct ensembl:ENSGALG00000001181 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3762
YWHAZ GeneProduct ensembl:ENSGALG00000031387 PMID: 9861170 PMID: 1317796
Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7534
YWHAH GeneProduct ensembl:ENSGALG00000006743 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7533
GJA3 GeneProduct ensembl:ENSGALG00000017137 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2700
ITPR1 GeneProduct ensembl:ENSGALG00000008294 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3708
ATP2B2 GeneProduct ensembl:ENSGALG00000030908 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:491
GJB3 GeneProduct ensembl:ENSGALG00000028424 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2707
SFN GeneProduct ensembl:ENSGALG00000028115 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2810
PRKD1 GeneProduct ensembl:ENSGALG00000009900 KPCM HUMAN
Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5587
GNG12 GeneProduct ensembl:ENSGALG00000026591 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:55970
GNAQ GeneProduct ensembl:ENSGALG00000015177 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2776
GNG11 GeneProduct ensembl:ENSGALG00000029899 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2791
PRKCD GeneProduct ensembl:ENSGALG00000002016 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5580
GNG7 GeneProduct ensembl:ENSGALG00000031980 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2788
Galphai3 GeneProduct ensembl:ENSGALG00000041700 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2773
PRKCE GeneProduct ensembl:ENSGALG00000010000 This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5581
RGS18 GeneProduct ensembl:ENSGALG00000021143 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:64407
RGS7 GeneProduct ensembl:ENSGALG00000039772 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6000
GRK5 GeneProduct ensembl:ENSGALG00000009403 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2869
PKIA GeneProduct ensembl:ENSGALG00000041759 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5569
RYR3 GeneProduct ensembl:ENSGALG00000009705 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6263
ITPR3 GeneProduct ensembl:ENSGALG00000003149 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3710
ADCY8 GeneProduct ensembl:ENSGALG00000030251 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:114
RGS19 GeneProduct ensembl:ENSGALG00000021079 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:10287
ADRA1B GeneProduct ensembl:ENSGALG00000001416 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:147
CALM GeneProduct ensembl:ENSGALG00000026445 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:808
FKBP12 GeneProduct ensembl:ENSGALG00000027151 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2280
GJB1 GeneProduct ensembl:ENSGALG00000005541 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2705
GJA8 GeneProduct ensembl:ENSGALG00000015488 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2703
RGS17 GeneProduct ensembl:ENSGALG00000026034 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:26575
ADCY3 GeneProduct ensembl:ENSGALG00000016608 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:109
YWHAE GeneProduct ensembl:ENSGALG00000002661 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7531
ANXA6 GeneProduct ensembl:ENSGALG00000004357 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:309
GNG5 GeneProduct ensembl:ENSGALG00000027561 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2787
ADCY9 GeneProduct ensembl:ENSGALG00000007779 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:115
RGS16 GeneProduct ensembl:ENSGALG00000033535 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6004
SLC8A1 GeneProduct ensembl:ENSGALG00000008544 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6546
YWHAQ GeneProduct ensembl:ENSGALG00000016433 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:10971
ADCY7 GeneProduct ensembl:ENSGALG00000003837 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:113
GNAZ GeneProduct ensembl:ENSGALG00000006719 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2781
ADRB3 GeneProduct ensembl:ENSGALG00000019018 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:155
CALR GeneProduct ensembl:ENSGALG00000040368 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:811
RGS11 GeneProduct ensembl:ENSGALG00000040648 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8786
PRKCZ GeneProduct ensembl:ENSGALG00000001270 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5590
PRKAR1A GeneProduct ensembl:ENSGALG00000004237 KAP0 HUMAN
Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5573
PKIG GeneProduct ensembl:ENSGALG00000031331 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:11142
RGS4 GeneProduct ensembl:ENSGALG00000002564 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5999
PRKCH GeneProduct ensembl:ENSGALG00000011889 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5583
PRKAR2B GeneProduct ensembl:ENSGALG00000008060 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5577
PRKCQ GeneProduct ensembl:ENSGALG00000034970 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5588
GNG3 GeneProduct ensembl:ENSGALG00000038905 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2785
PRKCA GeneProduct ensembl:ENSGALG00000025950 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5578
GJC2 GeneProduct ensembl:ENSGALG00000005331 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:57165
GNB1 GeneProduct ensembl:ENSGALG00000001334 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2782
CASQ2 GeneProduct ensembl:ENSGALG00000015018 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:845
GNAO1 GeneProduct ensembl:ENSGALG00000003163 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2775
SLC8A3 GeneProduct ensembl:ENSGALG00000009400 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6547
PLN GeneProduct ensembl:ENSGALG00000027583 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000198523
ATP2A2 GeneProduct ensembl:ENSGALG00000032287 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:488
RGS2 GeneProduct ensembl:ENSGALG00000042744 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5997
ARRB1 GeneProduct ensembl:ENSGALG00000033601 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:408
GNAS GeneProduct ensembl:ENSGALG00000030859 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2778
GJB2 GeneProduct ensembl:ENSGALG00000017136 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2706
CACNA1B GeneProduct ensembl:ENSGALG00000008456 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:774
GNAI1 GeneProduct ensembl:ENSGALG00000008382 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2770
CHRM3 GeneProduct ensembl:ENSGALG00000010778 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1131
RGS9 GeneProduct ensembl:ENSGALG00000029610 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8787
CHRM5 GeneProduct ensembl:ENSGALG00000009640 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1133
CAMK2B GeneProduct ensembl:ENSGALG00000033061 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:816
GJA4 GeneProduct ensembl:ENSGALG00000002532 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2701
GNG4 GeneProduct ensembl:ENSGALG00000010986 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2786
YWHAG GeneProduct ensembl:ENSGALG00000017358 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7532
CAMK1 GeneProduct ensembl:ENSGALG00000029912 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8536
GRK4 GeneProduct ensembl:ENSGALG00000015645 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2868
PRKAR2A GeneProduct ensembl:ENSGALG00000007023 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5576
ADRB2 GeneProduct ensembl:ENSGALG00000040035 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:154
RGS3 GeneProduct ensembl:ENSGALG00000008881 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5998
GJD2 GeneProduct ensembl:ENSGALG00000009845 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:57369
GRK6 GeneProduct ensembl:ENSGALG00000014054 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2870
ATP1B1 GeneProduct ensembl:ENSGALG00000015233 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:481
FXYD2 GeneProduct ensembl:ENSGALG00000007320 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:486
ATP1B3 GeneProduct ensembl:ENSGALG00000002764 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:483

References

  1. Calcium and the heart: a question of life and death. Marks AR. J Clin Invest. 2003 Mar;111(5):597–600. PubMed Europe PMC Scholia