MAPK signaling pathway (WP769)

Gallus gallus

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010

Authors

Kristina Hanspers , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , Denise Slenter , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Gallus gallus

Communities

Annotations

Pathway Ontology

mitogen activated protein kinase signaling pathway mitogen activated protein kinase signaling pathway

Participants

Label Type Compact URI Comment
LPS Metabolite chebi:16412
IP3 Metabolite chebi:16595
Ca2+ Metabolite hmdb:HMDB0000464
cAMP Metabolite hmdb:HMDB0000058
DAG Metabolite chebi:18035
TRAF6 GeneProduct ensembl:ENSGALG00000007932 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7189
MEF2C GeneProduct ensembl:ENSGALG00000014645 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4208
SRF GeneProduct ensembl:ENSGALG00000032029 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6722
RPS6KA3 GeneProduct ensembl:ENSGALG00000016406 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6197
MAP2K3 GeneProduct ensembl:ENSGALG00000041285 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5606
ELK4 GeneProduct ensembl:ENSGALG00000035274 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000158711
RAP1A GeneProduct ensembl:ENSGALG00000001476 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5906
CRK GeneProduct ensembl:ENSGALG00000031595 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1398
PDGFB GeneProduct ensembl:ENSGALG00000012178 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5155
AKT3 GeneProduct ensembl:ENSGALG00000034081 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:10000
ECSIT GeneProduct ensembl:ENSGALG00000043823 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:51295
MAP3K13 GeneProduct ensembl:ENSGALG00000006655 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9175
MAP3K7 GeneProduct ensembl:ENSGALG00000015596 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6885
MAPK9 GeneProduct ensembl:ENSGALG00000039099 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5601
GRB2 GeneProduct ensembl:ENSGALG00000008016 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2885
MKNK1 GeneProduct ensembl:ENSGALG00000010440 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8569
DUSP1 GeneProduct ensembl:ENSGALG00000040360 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1843
STMN1 GeneProduct ensembl:ENSGALG00000037927 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3925
EGFR GeneProduct ensembl:ENSGALG00000038089 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1956
PPP3CB GeneProduct ensembl:ENSGALG00000005243 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5532
PPP3CC GeneProduct ensembl:ENSGALG00000041413 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5533
NFATC1 GeneProduct ensembl:ENSGALG00000042534 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4772
MAPT GeneProduct ensembl:ENSGALG00000038894 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4137
RASGRP1 GeneProduct ensembl:ENSGALG00000009740 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:10125
RAP1B GeneProduct ensembl:ENSGALG00000009927 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5908
CD14 GeneProduct ensembl:ENSGALG00000039140 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:929
BDNF GeneProduct ensembl:ENSGALG00000012163 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:627
MAPK10 GeneProduct ensembl:ENSGALG00000011109 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5602
MOS GeneProduct ensembl:ENSGALG00000042082 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4342
STK4 GeneProduct ensembl:ENSGALG00000004098 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000101109
MAPK14 GeneProduct ensembl:ENSGALG00000042833 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1432
IKBKB GeneProduct ensembl:ENSGALG00000031832 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3551
ARRB1 GeneProduct ensembl:ENSGALG00000033601 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:408
LRRK2 GeneProduct ensembl:ENSGALG00000007161 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000188906
CASP3 GeneProduct ensembl:ENSGALG00000010638 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:836
MAPKAPK2 GeneProduct ensembl:ENSGALG00000000883 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9261
TNFRSF1A GeneProduct ensembl:ENSGALG00000039461 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000067182
MAP3K14 GeneProduct ensembl:ENSGALG00000000685 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000006062
HSPB1 GeneProduct ensembl:ENSGALG00000001926 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3315
MAP3K20 GeneProduct ensembl:ENSGALG00000035237 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:51776
GNA12 GeneProduct ensembl:ENSGALG00000004368 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2768
TGFB1 GeneProduct ensembl:ENSGALG00000031325 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7040
MAP3K1 GeneProduct ensembl:ENSGALG00000014718 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4214
MAP3K2 GeneProduct ensembl:ENSGALG00000011502 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:10746
MAX GeneProduct ensembl:ENSGALG00000032249 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4149
DUSP10 GeneProduct ensembl:ENSGALG00000009450 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:11221
RASGRF2 GeneProduct ensembl:ENSGALG00000015598 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5924
MAP4K4 GeneProduct ensembl:ENSGALG00000016781 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9448
PDGFRB GeneProduct ensembl:ENSGALG00000030613 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5159
TAB1 GeneProduct ensembl:ENSGALG00000012150 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:10454
MAP3K4 GeneProduct ensembl:ENSGALG00000020003 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4216
GADD45A GeneProduct ensembl:ENSGALG00000025977 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1647
MAP2K5 GeneProduct ensembl:ENSGALG00000007930 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5607
IL1R1 GeneProduct ensembl:ENSGALG00000030526 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3554
RAC2 GeneProduct ensembl:ENSGALG00000012456 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5880
PRKCD GeneProduct ensembl:ENSGALG00000002016 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5580
MAP2K1 GeneProduct ensembl:ENSGALG00000007687 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5604
cRac1A GeneProduct ensembl:ENSGALG00000007130 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5879
PTPN7 GeneProduct ensembl:ENSGALG00000036093 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5778
IL1R2 GeneProduct ensembl:ENSGALG00000046326 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7850
TAB2 GeneProduct ensembl:ENSGALG00000012356 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:23118
ChALK5 GeneProduct ensembl:ENSGALG00000033179 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7046
MAPK1 GeneProduct ensembl:ENSGALG00000001501 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5594
PTPRR GeneProduct ensembl:ENSGALG00000010148 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5801
PTPN5 GeneProduct ensembl:ENSGALG00000006368 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:84867
PLA2G4D GeneProduct ensembl:ENSGALG00000045155 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000159337
BRAF GeneProduct ensembl:ENSGALG00000012865 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:673
NTRK1 GeneProduct ensembl:ENSGALG00000019019 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4914
ATF2 GeneProduct ensembl:ENSGALG00000009287 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1386
MAP2K4 GeneProduct ensembl:ENSGALG00000032178 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6416
FOS GeneProduct ensembl:ENSGALG00000028037 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2353
MYC GeneProduct ensembl:ENSGALG00000033631 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4609
SOS2 GeneProduct ensembl:ENSGALG00000012273 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6655
TGFB2 GeneProduct ensembl:ENSGALG00000009612 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7042
DUSP4 GeneProduct ensembl:ENSGALG00000011419 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1846
CACNG3 GeneProduct ensembl:ENSGALG00000038087 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = H:CACNG3
HSPA8 GeneProduct ensembl:ENSGALG00000006512 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3312
MAPK12 GeneProduct ensembl:ENSGALG00000019384 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6300
MAPK8IP1 GeneProduct ensembl:ENSGALG00000033060 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000121653
PPM1A GeneProduct ensembl:ENSGALG00000011917 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5494
il-1beta GeneProduct ensembl:ENSGALG00000029940 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3553
TRAF2 GeneProduct ensembl:ENSGALG00000042838 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7186
MAPK13 GeneProduct ensembl:ENSGALG00000030966 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5603
TAOK1 GeneProduct ensembl:ENSGALG00000004082 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:57551
MAP2K6 GeneProduct ensembl:ENSGALG00000004370 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5608
DUSP8 GeneProduct ensembl:ENSGALG00000006647 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000184545
AKT2 GeneProduct ensembl:ENSGALG00000037736 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:208
MAPKAPK5 GeneProduct ensembl:ENSGALG00000004743 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8550
RASA2 GeneProduct ensembl:ENSGALG00000002850 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5922
DUSP7 GeneProduct ensembl:ENSGALG00000041650 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1849
FGFR1 GeneProduct ensembl:ENSGALG00000039786 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2260
TGFB3 GeneProduct ensembl:ENSGALG00000010346 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7043
PPP3CA GeneProduct ensembl:ENSGALG00000039498 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5530
EGF GeneProduct ensembl:ENSGALG00000012155 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1950
MAP3K6 GeneProduct ensembl:ENSGALG00000030706 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9064
MAP3K8 GeneProduct ensembl:ENSGALG00000007356 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1326
NGF GeneProduct ensembl:ENSGALG00000002556 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000134259
CRKL GeneProduct ensembl:ENSGALG00000006390 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1399
MAPK8 GeneProduct ensembl:ENSGALG00000006109 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5599
NR4A1 GeneProduct ensembl:ENSGALG00000043727 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3164
PRKCA GeneProduct ensembl:ENSGALG00000025950 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000154229
ATF4 GeneProduct ensembl:ENSGALG00000012135 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:468
PDGF-A GeneProduct ensembl:ENSGALG00000003642 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000197461
NTRK2 GeneProduct ensembl:ENSGALG00000012594 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000148053
TNFSF6 GeneProduct ensembl:ENSGALG00000003076 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:356
PDGFRB GeneProduct ensembl:ENSGALG00000030613 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000113721
PPM1B GeneProduct ensembl:ENSGALG00000030691 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5495
FGFR2 GeneProduct ensembl:ENSGALG00000009495 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000066468
CDC42 GeneProduct ensembl:ENSGALG00000004796 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:998
FGFR3 GeneProduct ensembl:ENSGALG00000015708 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000068078
LAMTOR3 GeneProduct ensembl:ENSGALG00000000055 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8649
FGFR4 GeneProduct ensembl:ENSGALG00000028543 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000160867
JUN GeneProduct ensembl:ENSGALG00000010870 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3725
SOS1 GeneProduct ensembl:ENSGALG00000039450 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000115904
JUND GeneProduct ensembl:ENSGALG00000043641 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3727
HRAS GeneProduct ensembl:ENSGALG00000040551 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000174775
RPS6KA5 GeneProduct ensembl:ENSGALG00000030580 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9252
MAP3K12 GeneProduct ensembl:ENSGALG00000031572 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7786
RRAS2 GeneProduct ensembl:ENSGALG00000005998 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000133818
NFKB1 GeneProduct ensembl:ENSGALG00000012304 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4790
GNG12 GeneProduct ensembl:ENSGALG00000026591 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000172380
NF1 GeneProduct ensembl:ENSGALG00000005660 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000196712
AKT1 GeneProduct ensembl:ENSGALG00000011620 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:207
RASGRP3 GeneProduct ensembl:ENSGALG00000010435 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000152689
RASA1 GeneProduct ensembl:ENSGALG00000031015 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5921
RASGRF1 GeneProduct ensembl:ENSGALG00000008262 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000058335
NTF3 GeneProduct ensembl:ENSGALG00000027299 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000185652
RAPGEF2 GeneProduct ensembl:ENSGALG00000020249 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000109756
PRKACB GeneProduct ensembl:ENSGALG00000028530 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000142875
STK3 GeneProduct ensembl:ENSGALG00000032850 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6788
DUSP3 GeneProduct ensembl:ENSGALG00000035369 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000108861
MAP4K3 GeneProduct ensembl:ENSGALG00000039720 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8491
CHUK GeneProduct ensembl:ENSGALG00000003289 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000213341
TGFBR2 GeneProduct ensembl:ENSGALG00000011442 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7048
NFKB2 GeneProduct ensembl:ENSGALG00000005653 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000077150
RELA GeneProduct ensembl:ENSGALG00000039409 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000173039
PPP3R1 GeneProduct ensembl:ENSGALG00000023648 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5534
NLK GeneProduct ensembl:ENSGALG00000005699 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:51701
DUSP16 GeneProduct ensembl:ENSGALG00000034033 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000111266
FAS GeneProduct ensembl:ENSGALG00000006351 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:355
MKNK2 GeneProduct ensembl:ENSGALG00000003845 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000099875
PLA2G4A GeneProduct ensembl:ENSGALG00000005065 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000116711
NFATC3 GeneProduct ensembl:ENSGALG00000003396 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000072736
MAP3K5 GeneProduct ensembl:ENSGALG00000013892 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4217
TAOK3 GeneProduct ensembl:ENSGALG00000007396 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000135090
DUSP6 GeneProduct ensembl:ENSGALG00000011207 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1848
MAP2K2 GeneProduct ensembl:ENSGALG00000001267 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5605
MAPK11 GeneProduct ensembl:ENSGALG00000040023 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000185386
MAPKAPK3 GeneProduct ensembl:ENSGALG00000002283 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000114738
cRac1B GeneProduct ensembl:ENSGALG00000040606 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000169750
MAPK8IP2 GeneProduct ensembl:ENSGALG00000035559 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000008735
MAPK8IP3 GeneProduct ensembl:ENSGALG00000029514 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000138834
FLNB GeneProduct ensembl:ENSGALG00000005678 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000136068
HSPA2 GeneProduct ensembl:ENSGALG00000011715 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000126803
MRAS GeneProduct ensembl:ENSGALG00000011592 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:22808
NRAS GeneProduct ensembl:ENSGALG00000026692 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4893
KRAS GeneProduct ensembl:ENSGALG00000030943 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3845
RAF1 GeneProduct ensembl:ENSGALG00000004998 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5894
PLA2G4F GeneProduct ensembl:ENSGALG00000043591 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000168907
PLA2G4B GeneProduct ensembl:ENSGALG00000045155 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000243708
PLA2G4E GeneProduct ensembl:ENSGALG00000026584 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000188089
CACNG2 GeneProduct ensembl:ENSGALG00000031977 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000166862
CACNG5 GeneProduct ensembl:ENSGALG00000003911 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000075429
CACNG4 GeneProduct ensembl:ENSGALG00000026091 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000075461
CACNA2D3 GeneProduct ensembl:ENSGALG00000005400 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000157445
CACNG7 GeneProduct ensembl:ENSGALG00000042886 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000105605
CACNA1A GeneProduct ensembl:ENSGALG00000037131 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000141837
CACNA1B GeneProduct ensembl:ENSGALG00000008456 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000148408
CACNA1C GeneProduct ensembl:ENSGALG00000013022 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000151067
CACNA1D GeneProduct ensembl:ENSGALG00000005332 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000157388
CACNA1E GeneProduct ensembl:ENSGALG00000003833 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000198216
CACNA1F GeneProduct ensembl:ENSGALG00000029356 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000102001
CACNA1S GeneProduct ensembl:ENSGALG00000037744 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000081248
CACNA2D1 GeneProduct ensembl:ENSGALG00000008486 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000153956
CACNB1 GeneProduct ensembl:ENSGALG00000025788 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000067191
CACNB2 GeneProduct ensembl:ENSGALG00000008591 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000165995
CACNB4 GeneProduct ensembl:ENSGALG00000035466 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000182389
CACNG1 GeneProduct ensembl:ENSGALG00000027771 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000108878
CACNA1I GeneProduct ensembl:ENSGALG00000035051 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000100346
CACNA1H GeneProduct ensembl:ENSGALG00000005215 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000196557
CACNA1G GeneProduct ensembl:ENSGALG00000007623 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000006283
CACNA2D2 GeneProduct ensembl:ENSGALG00000038242 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000007402
CACNA2D4 GeneProduct ensembl:ENSGALG00000013007 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000151062
FGF4 GeneProduct ensembl:ENSGALG00000007562 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2249
FGF1 GeneProduct ensembl:ENSGALG00000031255 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000113578
FGF2 GeneProduct ensembl:ENSGALG00000011835 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000138685
FGF3 GeneProduct ensembl:ENSGALG00000026853 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000186895
FGF4 GeneProduct ensembl:ENSGALG00000007562 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000075388
FGF5 GeneProduct ensembl:ENSGALG00000045521 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000138675
FGF6 GeneProduct ensembl:ENSGALG00000017287 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000111241
Fgf7 GeneProduct ensembl:ENSGALG00000028158 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000140285
FGF8 GeneProduct ensembl:ENSGALG00000007706 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000107831
FGF9 GeneProduct ensembl:ENSGALG00000025748 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000102678
FGF10 GeneProduct ensembl:ENSGALG00000014872 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000070193
FGF12 GeneProduct ensembl:ENSGALG00000036971 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000114279
FGF13 GeneProduct ensembl:ENSGALG00000006508 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000129682
FGF14 GeneProduct ensembl:ENSGALG00000016866 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000102466
FGF20 GeneProduct ensembl:ENSGALG00000013663 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000078579
FGF22 GeneProduct ensembl:ENSGALG00000041822 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000070388
FGF23 GeneProduct ensembl:ENSGALG00000027791 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000118972
FGF-18 GeneProduct ensembl:ENSGALG00000002203 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000156427
Fgf16 GeneProduct ensembl:ENSGALG00000007806 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000196468
FGF19 GeneProduct ensembl:ENSGALG00000028376 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000162344
PAK2 GeneProduct ensembl:ENSGALG00000006426 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5062
PAK1 GeneProduct ensembl:ENSGALG00000000681 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5058

References

  1. Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38. Harper SJ, LoGrasso P. Cell Signal. 2001 May;13(5):299–310. PubMed Europe PMC Scholia
  2. MAP kinases. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, et al. Chem Rev. 2001 Aug;101(8):2449–76. PubMed Europe PMC Scholia
  3. Docking interactions in the mitogen-activated protein kinase cascades. Tanoue T, Nishida E. Pharmacol Ther. 2002;93(2–3):193–202. PubMed Europe PMC Scholia
  4. Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system. Takeda K, Ichijo H. Genes Cells. 2002 Nov;7(11):1099–111. PubMed Europe PMC Scholia
  5. The role of mitogen-activated protein kinase pathways in Alzheimer’s disease. Zhu X, Lee H gon, Raina AK, Perry G, Smith MA. Neurosignals. 2002;11(5):270–81. PubMed Europe PMC Scholia
  6. Trk receptors: roles in neuronal signal transduction. Huang EJ, Reichardt LF. Annu Rev Biochem. 2003;72:609–42. PubMed Europe PMC Scholia
  7. Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, et al. Toxicol Lett. 2003 Aug 28;143(3):323–30. PubMed Europe PMC Scholia
  8. MAPK pathways in radiation responses. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S. Oncogene. 2003 Sep 1;22(37):5885–96. PubMed Europe PMC Scholia
  9. Transcriptional regulation by the MAP kinase signaling cascades. Yang SH, Sharrocks AD, Whitmarsh AJ. Gene. 2003 Nov 27;320:3–21. PubMed Europe PMC Scholia
  10. MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta. Abell AN, Granger DA, Johnson GL. J Biol Chem. 2007 Oct 19;282(42):30476–84. PubMed Europe PMC Scholia
  11. (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, et al. Cell Death Differ. 2012 Oct;19(10):1623–33. PubMed Europe PMC Scholia