Glutathione and one-carbon metabolism (WP730)
Mus musculus
This pathway provides a combined view on the one-carbon and glutathione metabolism pathways. Based on existing pathways: * [[Pathway:WP435|WP435]] * [[Pathway:WP164|WP164]]
Authors
Thomas Kelder , Lorraine Brennan , Martina Summer-Kutmon , Egon Willighagen , Alex Pico , Lauren J. Dupuis , Nhung Pham , and Eric WeitzActivity
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Cited In
- Proteomic profiling of salivary gland after nonviral gene transfer mediated by conventional plasmids and minicircles (2014).
- Podocyte-specific KLF6 primes proximal tubule CaMK1D signaling to attenuate diabetic kidney disease (2024).
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
classic metabolic pathway carbon fixation pathway glutathione metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| 5-Methyl Tetrahydrofolate | Metabolite | cas:134-35-0 | |
| Cysteinyl-glycine | Metabolite | kegg.compound:C01419 | |
| Homocysteine | Metabolite | cas:6027-13-0 | |
| Oxidized glutathione | Metabolite | kegg.compound:C00127 | |
| L-Amino acid | Metabolite | kegg.compound:C00151 | |
| Methionine | Metabolite | cas:63-68-3 | |
| NADPH | Metabolite | hmdb:HMDB0000221 | |
| S-adenosylhomocysteine | Metabolite | cas:979-92-0 | |
| Betaine | Metabolite | cas:107-43-7 | |
| L-Cysteine | Metabolite | kegg.compound:C00097 | |
| NADP+ | Metabolite | hmdb:HMDB0000217 | |
| L-Glutamate | Metabolite | kegg.compound:C00025 | |
| (5-L-Glutamyl)-L-amino acid | Metabolite | kegg.compound:C03740 | |
| Glycine | Metabolite | hmdb:HMDB0000123 | |
| Glutathione (reduced) | Metabolite | kegg.compound:C00051 | |
| Tetrahydrofolate | Metabolite | cas:135-16-0 | |
| g-L-Glutamyl-L-cysteine | Metabolite | kegg.compound:C00669 | |
| DMG | Metabolite | cas:107-43-7 | |
| 5,10-Methylene Tetrahydrofolate | Metabolite | cas:25513-46-6 | |
| S-Adenosylmethionine | Metabolite | cas:29908-03-0 | |
| 5-Oxoproline | Metabolite | kegg.compound:C01879 | |
| ANPEP | GeneProduct | ncbigene:16790 | |
| G6PD | GeneProduct | ncbigene:14381 | |
| 1.11.1.12 | GeneProduct | eccode:1.11.1.12 | |
| GGTLA1 | GeneProduct | ncbigene:23887 | |
| GPX1 | GeneProduct | ncbigene:14775 | |
| BHMT | GeneProduct | ncbigene:12116 | |
| 1.8.4.2 | GeneProduct | eccode:1.8.4.2 | |
| DNMT1 | GeneProduct | ncbigene:13433 | |
| MTRR | GeneProduct | ncbigene:210009 | |
| MTHFR | GeneProduct | ncbigene:17769 | |
| 2.3.2.4 | GeneProduct | eccode:2.3.2.4 | |
| GCLM | GeneProduct | ncbigene:14630 | |
| GSR | GeneProduct | ncbigene:14782 | |
| 1.8.4.4 | GeneProduct | eccode:1.8.4.4 | |
| GGT1 | GeneProduct | ncbigene:14598 | (5-L-Glutamyl)-L-amino acid |
| GSS | GeneProduct | ncbigene:14854 | |
| GCLC | GeneProduct | ncbigene:14629 | |
| AMT | GeneProduct | ncbigene:434437 | KEGG database: One carbon pool by folate - Homo sapiens (human) |
| KIAA0828 | GeneProduct | ncbigene:74340 | KEGG Database Methionine metabolism - Homo sapiens (human) |
| MTR | GeneProduct | ncbigene:238505 | |
| MAT2B | GeneProduct | ncbigene:108645 | KEGG Database Methionine metabolism - Homo sapiens (human) |
| 3.4.11.4 | GeneProduct | eccode:3.4.11.4 | |
| 1.8.4.7 | GeneProduct | eccode:1.8.4.7 | |
| 1.8.3.3 | GeneProduct | eccode:1.8.3.3 | |
| 1.8.5.1 | GeneProduct | eccode:1.8.5.1 | |
| DNMT3a | GeneProduct | ncbigene:13435 | KEGG Database Methionine metabolism - Homo sapiens (human) |
| 2.8.1.3 | GeneProduct | eccode:2.8.1.3 | |
| 1.5.4.1 | GeneProduct | eccode:1.5.4.1 | |
| Chdh | GeneProduct | ncbigene:218865 | |
| GGT1 | GeneProduct | ncbigene:14598 | |
| GPX2 | GeneProduct | ncbigene:14776 | |
| DNMT3b | GeneProduct | ncbigene:13436 | KEGG database: Methionine metabolism - Homo sapiens (human) |
| 1.8.4.1 | GeneProduct | eccode:1.8.4.1 | |
| 1.8.4.3 | GeneProduct | eccode:1.8.4.3 | |
| MAT1A | GeneProduct | ncbigene:11720 | KEGG Database Methionine metabolism - Homo sapiens (human) |
| Oplah | GeneProduct | ncbigene:75475 | |
| 1.1.1.43 | GeneProduct | eccode:1.1.1.43 | |
| IDH1 | GeneProduct | ncbigene:15926 | |
| AHCY | GeneProduct | ncbigene:269378 | KEGG Database Methionine metabolism - Homo sapiens (human) |
| SHMT1 | GeneProduct | ncbigene:20425 | |
| GPX3 | GeneProduct | ncbigene:14778 | |
| SHMT2 | GeneProduct | ncbigene:108037 | KEGG database: One carbon pool by folate - Homo sapiens (human) |
| GPX4 | GeneProduct | ncbigene:625249 | |
| CBS | GeneProduct | ncbigene:12411 | |
| CTH | GeneProduct | ncbigene:107869 |
References
- Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses’ Health Study. Hazra A, Wu K, Kraft P, Fuchs CS, Giovannucci EL, Hunter DJ. Carcinogenesis. 2007 Jul;28(7):1510–9. PubMed Europe PMC Scholia