The nucleosome remodelling complex (WP5572)

Homo sapiens

This pathway shows the nucleosome remodeling complex. These processes are involved in the Tessadori-Bicknell-van Haaften syndrome 3 (TEBINVAD) - for an overview of this syndrome see WP5575.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Jorinde Lohmann , Egon Willighagen , Yuanyuan Duan , and Friederike Ehrhart

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Rare Diseases

Annotations

Disease Ontology

Werner syndrome epilepsy

Pathway Ontology

Participants

Label Type Compact URI Comment
Double-stranded DNA Metabolite chebi:4705
SSRP1 GeneProduct ensembl:ENSG00000149136
CHAF1B GeneProduct ensembl:ENSG00000159259
RBBP4 GeneProduct ensembl:ENSG00000162521
SUPT16H GeneProduct ensembl:ENSG00000092201
CHAF1A GeneProduct ensembl:ENSG00000167670
PCNA GeneProduct ensembl:ENSG00000132646
XRCC6 GeneProduct ensembl:ENSG00000196419
XRCC5 GeneProduct ensembl:ENSG00000079246
DAXX GeneProduct ensembl:ENSG00000204209
NAP1L1 GeneProduct ensembl:ENSG00000187109
PRKDC GeneProduct ensembl:ENSG00000253729
MCM2 GeneProduct ensembl:ENSG00000073111
ASF1A GeneProduct ensembl:ENSG00000111875
ASF1B GeneProduct ensembl:ENSG00000105011
CHEK2 GeneProduct ensembl:ENSG00000183765
IPO4 GeneProduct ensembl:ENSG00000196497
NASP GeneProduct ensembl:ENSG00000132780
HAT1 GeneProduct ensembl:ENSG00000128708
H4C5 GeneProduct ensembl:ENSG00000276966
H2A Protein uniprot:B2R5B3
H2B Protein uniprot:B4DR52
H3 Protein uniprot:B4E380
H4 Protein None

References

  1. Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation. Richardson RT, Alekseev OM, Grossman G, Widgren EE, Thresher R, Wagner EJ, et al. J Biol Chem. 2006 Jul 28;281(30):21526–34. PubMed Europe PMC Scholia
  2. Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones. Okuwaki M, Kato K, Nagata K. Genes Cells. 2010 Jan;15(1):13–27. PubMed Europe PMC Scholia
  3. Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. Liu CP, Xiong C, Wang M, Yu Z, Yang N, Chen P, et al. Nat Struct Mol Biol. 2012 Dec;19(12):1287–92. PubMed Europe PMC Scholia
  4. Histone chaperones in nucleosome assembly and human disease. Burgess RJ, Zhang Z. Nat Struct Mol Biol. 2013 Jan;20(1):14–22. PubMed Europe PMC Scholia
  5. Hypomorphic PCNA mutation underlies a human DNA repair disorder. Baple EL, Chambers H, Cross HE, Fawcett H, Nakazawa Y, Chioza BA, et al. J Clin Invest. 2014 Jul;124(7):3137–46. PubMed Europe PMC Scholia
  6. Structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2. Wang H, Wang M, Yang N, Xu RM. Protein Cell. 2015 Sep;6(9):693–7. PubMed Europe PMC Scholia