The nucleosome remodelling complex (WP5572)
Homo sapiens
This pathway shows the nucleosome remodeling complex. These processes are involved in the Tessadori-Bicknell-van Haaften syndrome 3 (TEBINVAD) - for an overview of this syndrome see WP5575.
For a description of pathway objects, see the WikiPathways Legend.
Authors
Jorinde Lohmann , Egon Willighagen , Yuanyuan Duan , and Friederike EhrhartActivity
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Cited In
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Organisms
Homo sapiensCommunities
Rare DiseasesAnnotations
Disease Ontology
Werner syndrome epilepsyPathway Ontology
Label | Type | Compact URI | Comment |
---|---|---|---|
Double-stranded DNA | Metabolite | chebi:4705 | |
SSRP1 | GeneProduct | ensembl:ENSG00000149136 | |
CHAF1B | GeneProduct | ensembl:ENSG00000159259 | |
RBBP4 | GeneProduct | ensembl:ENSG00000162521 | |
SUPT16H | GeneProduct | ensembl:ENSG00000092201 | |
CHAF1A | GeneProduct | ensembl:ENSG00000167670 | |
PCNA | GeneProduct | ensembl:ENSG00000132646 | |
XRCC6 | GeneProduct | ensembl:ENSG00000196419 | |
XRCC5 | GeneProduct | ensembl:ENSG00000079246 | |
DAXX | GeneProduct | ensembl:ENSG00000204209 | |
NAP1L1 | GeneProduct | ensembl:ENSG00000187109 | |
PRKDC | GeneProduct | ensembl:ENSG00000253729 | |
MCM2 | GeneProduct | ensembl:ENSG00000073111 | |
ASF1A | GeneProduct | ensembl:ENSG00000111875 | |
ASF1B | GeneProduct | ensembl:ENSG00000105011 | |
CHEK2 | GeneProduct | ensembl:ENSG00000183765 | |
IPO4 | GeneProduct | ensembl:ENSG00000196497 | |
NASP | GeneProduct | ensembl:ENSG00000132780 | |
HAT1 | GeneProduct | ensembl:ENSG00000128708 | |
H4C5 | GeneProduct | ensembl:ENSG00000276966 | |
H2A | Protein | uniprot:B2R5B3 | |
H2B | Protein | uniprot:B4DR52 | |
H3 | Protein | uniprot:B4E380 | |
H4 | Protein | None |
References
- Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation. Richardson RT, Alekseev OM, Grossman G, Widgren EE, Thresher R, Wagner EJ, et al. J Biol Chem. 2006 Jul 28;281(30):21526–34. PubMed Europe PMC Scholia
- Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones. Okuwaki M, Kato K, Nagata K. Genes Cells. 2010 Jan;15(1):13–27. PubMed Europe PMC Scholia
- Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. Liu CP, Xiong C, Wang M, Yu Z, Yang N, Chen P, et al. Nat Struct Mol Biol. 2012 Dec;19(12):1287–92. PubMed Europe PMC Scholia
- Histone chaperones in nucleosome assembly and human disease. Burgess RJ, Zhang Z. Nat Struct Mol Biol. 2013 Jan;20(1):14–22. PubMed Europe PMC Scholia
- Hypomorphic PCNA mutation underlies a human DNA repair disorder. Baple EL, Chambers H, Cross HE, Fawcett H, Nakazawa Y, Chioza BA, et al. J Clin Invest. 2014 Jul;124(7):3137–46. PubMed Europe PMC Scholia
- Structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2. Wang H, Wang M, Yang N, Xu RM. Protein Cell. 2015 Sep;6(9):693–7. PubMed Europe PMC Scholia