Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor (WP5545)

Homo sapiens

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This pathway visualises the potential mechanisms of TGF-β3-mediated ENPP2 (or ATX) expression and fibrotic changes in HTM cells. This pathway was created using the PFOCR project, based on these results.

Authors

Denise Slenter , Egon Willighagen , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

transforming growth factor-beta signaling pathway signaling pathway

Disease Ontology

glaucoma

Cell Type Ontology

trabecular meshwork cell

Participants
Query Drugst.One

Label Type Compact URI Comment
FN1 GeneProduct ncbigene:2335 'Fibronectin' originally
'Fibronectin exists as a protein dimer, consisting of two nearly identical monomers linked by a pair of disulfide bonds.' Source: Wikipedia, https://en.wikipedia.org/wiki/Fibronectin
ENPP2 GeneProduct ncbigene:5168 alternative name: ATX
TGFB3 GeneProduct ncbigene:7043 OCR lexicon match: TGF-B3
STAT3 GeneProduct ncbigene:6774 OCR lexicon match: STAT3
LPA GeneProduct ncbigene:4018 OCR lexicon match: LPA
RHO GeneProduct ncbigene:6010 OCR lexicon match: RHO
MAPK8 GeneProduct ncbigene:5599 OCR lexicon match: JNK
MAPK9 GeneProduct ncbigene:5601 OCR lexicon match: JNK
MAPK10 GeneProduct ncbigene:5602 OCR lexicon match: JNK
CCN2 GeneProduct ncbigene:1490 alternative name: CTGF
COL1A1 GeneProduct ncbigene:1277 OCR lexicon match: COL1A1
ACTA2 GeneProduct ncbigene:59 'α-SMA' originally
TGFB1 GeneProduct ncbigene:7040 OCR lexicon match: TGF-B1
TGFB2 GeneProduct ncbigene:7042 OCR lexicon match: TGF-B2
SMAD3 GeneProduct ncbigene:4088 OCR lexicon match: SMAD3
SIS3 Protein uniprot:Q8GYT9

References

  1. Fibrotic Response of Human Trabecular Meshwork Cells to Transforming Growth Factor-Beta 3 and Autotaxin in Aqueous Humor. Liu M, Honjo M, Yamagishi R, Igarashi N, Nakamura N, Kurano M, et al. Biomolecules. 2022 Sep 3;12(9):1231. PubMed Europe PMC Scholia