Regulation of cytotoxic T cell responses by Malat1 - miR-15/16 circuit (WP5489)

Homo sapiens

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Regulation of activation and differentiation of cytotoxic T cells by long non-coding RNA Malat1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) and the microRNA family miR-15/16. This pathway model is developed based on Figure 8 in (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10735224/ Wheeler et al).

Authors

Kristina Hanspers and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

memory T cell cytotoxic T cell

Pathway Ontology

adaptive immune response pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
IL2 GeneProduct hgnc.symbol:IL2
BCL2 GeneProduct hgnc.symbol:BCL2
TRA GeneProduct hgnc.symbol:12027
CD80 GeneProduct hgnc.symbol:CD80
CD3E GeneProduct hgnc.symbol:CD3E
MALAT1 GeneProduct ncbigene:378938
CD247 GeneProduct hgnc.symbol:CD247
CD3G GeneProduct hgnc.symbol:CD3G
CD28 GeneProduct hgnc.symbol:CD28
CD3D GeneProduct hgnc.symbol:CD3D
CD27 GeneProduct hgnc.symbol:CD27
CD43 GeneProduct hgnc.symbol:SPN
TRB GeneProduct hgnc.symbol:12155
CD86 GeneProduct hgnc.symbol:CD86

References

  1. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Shapiro VS, Truitt KE, Imboden JB, Weiss A. Mol Cell Biol. 1997 Jul;17(7):4051–8. PubMed Europe PMC Scholia
  2. The lncRNA Malat1 inhibits miR-15/16 to enhance cytotoxic T cell activation and memory cell formation. Wheeler BD, Gagnon JD, Zhu WS, Muñoz-Sandoval P, Wong SK, Simeonov DS, et al. Elife. 2023 Dec 21;12:RP87900. PubMed Europe PMC Scholia