Pathways into methionine and folate cycles (WP5488)

Homo sapiens

Authors

Alexmadsen1 , Eric Weitz , and Alex Pico

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

autism spectrum disorder anxiety disorder attention deficit hyperactivity disorder generalized anxiety disorder

Pathway Ontology

neurotransmitter metabolic pathway tetrahydrobiopterin metabolic pathway endocannabinoid signaling pathway endocannabinoid metabolic pathway epinephrine signaling pathway folate metabolic pathway kynurenine metabolic pathway methionine cycle/metabolic pathway folate mediated one-carbon metabolic pathway

References

1. The proteasome and its role in the degradation of oxidized proteins. Jung T, Grune T. IUBMB Life [Internet]. 2008 Nov;60(11):743–52. Available from: http://dx.doi.org/10.1002/iub.114 DOI Scholia
2. Disorders affecting vitamin B6 metabolism. Wilson MP, Plecko B, Mills PB, Clayton PT. J of Inher Metab Disea [Internet]. 2019 Mar 20;42(4):629–46. Available from: http://dx.doi.org/10.1002/jimd.12060 DOI Scholia
3. Methionine synthase and methionine synthase reductase interact with MMACHC and with MMADHC. Bassila C, Ghemrawi R, Flayac J, Froese DS, Baumgartner MR, Guéant JL, et al. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease [Internet]. 2017 Jan;1863(1):103–12. Available from: http://dx.doi.org/10.1016/j.bbadis.2016.10.016 DOI Scholia
4. Association between gene promoter methylation of the one-carbon metabolism pathway and serum folate among patients with hyperhomocysteinemia. Huang X, Zhao Q, Li D, Ren B, Yue L, Shi F, et al. Eur J Clin Nutr [Internet]. 2020 May 13;74(12):1677–84. Available from: http://dx.doi.org/10.1038/s41430-020-0657-9 DOI Scholia
5. Toward a better understanding of folate metabolism in health and disease. Zheng Y, Cantley LC. Journal of Experimental Medicine [Internet]. 2018 Dec 26;216(2):253–66. Available from: http://dx.doi.org/10.1084/jem.20181965 DOI Scholia
6. Three Main Causes of Homocystinuria: CBS, cblC and MTHFR Deficiency. What do they Have in Common? Hoss GRW, Poloni S, Blom HJ, Schwartz IVD. J inborn errors metab screen [Internet]. 2019;7. Available from: http://dx.doi.org/10.1590/2326-4594-jiems-2019-0007 DOI Scholia
7. Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors. Engevik MA, Morra CN, Röth D, Engevik K, Spinler JK, Devaraj S, et al. Front Microbiol [Internet]. 2019 Oct 9;10. Available from: http://dx.doi.org/10.3389/fmicb.2019.02305 DOI Scholia
8. Vitamin B12 (Cobalamin) and Micronutrient Fortification in Food Crops Using Nanoparticle Technology. Oh S, Cave G, Lu C. Front Plant Sci [Internet]. 2021 Aug 23;12. Available from: http://dx.doi.org/10.3389/fpls.2021.668819 DOI Scholia
9. Tetrahydrobiopterin: Beyond Its Traditional Role as a Cofactor. Eichwald T, da Silva L de B da, Staats Pires ACS, Niero L, Schnorrenberger E, Filho CC, et al. Antioxidants [Internet]. 2023 May 3;12(5):1037. Available from: http://dx.doi.org/10.3390/antiox12051037 DOI Scholia
10. Development of Novel Experimental Models to Study Flavoproteome Alterations in Human Neuromuscular Diseases: The Effect of Rf Therapy. Tolomeo M, Nisco A, Leone P, Barile M. IJMS [Internet]. 2020 Jul 26;21(15):5310. Available from: http://dx.doi.org/10.3390/ijms21155310 DOI Scholia
11. B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review. Kennedy D. Nutrients [Internet]. 2016 Jan 27;8(2):68. Available from: http://dx.doi.org/10.3390/nu8020068 DOI Scholia
12. Riboflavin metabolism: role in mitochondrial function. Balasubramaniam S, Yaplito-Lee J. jtgg [Internet]. 2020; Available from: http://dx.doi.org/10.20517/jtgg.2020.34 DOI Scholia
13. Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum. Raux E, Schubert HL, Warren MJ. Cell Mol Life Sci. 2000 Dec;57(13–14):1880–93. PubMed Europe PMC Scholia
14. Mechanism of vitamin B12-responsiveness in cblC methylmalonic aciduria with homocystinuria. Froese DS, Zhang J, Healy S, Gravel RA. Mol Genet Metab. 2009 Dec;98(4):338–43. PubMed Europe PMC Scholia
15. Inborn errors of cobalamin absorption and metabolism. Watkins D, Rosenblatt DS. Am J Med Genet C Semin Med Genet. 2011 Feb 15;157C(1):33–44. PubMed Europe PMC Scholia
16. URL: https://medlineplus.gov/genetics/gene/hcfc1/#synonyms