Hallmark of cancer: non-mutational epigenetic reprogramming (WP5483)

Homo sapiens

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Hallmarks of Cancer: Nonmutational epigenetical programming

Authors

PhilipErnst , Eric Weitz , Kristina Hanspers , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

cancer pathway regulatory pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
METTL3 Protein ensembl:NSG00000083838
FTO Protein ensembl:ENSG00000140718
ALKBH5 Protein ensembl:ENSG00000150867
YTHDF2 Protein ensembl:ENSG00000118454 YTHDF2 binds to m6A regions to promote degradation of mRNA
HDAC1 Protein ensembl:ENSG00000116478
YTHDF1 Protein ensembl:ENSG00000162408
DNMT1 Protein ensembl:ENSG00000130816
YTHDC1 Protein ensembl:ENSG00000169047
DNMT3A Protein ensembl:ENSG00000119772
METTL14 Protein ensembl:ENSG00000167741
DNMT3B Protein ensembl:ENSG00000142089
EP300 Protein ensembl:ENSG00000100393
CREBP Protein ensembl:ENSG00000005339
HDAC2 Protein ensembl:ENSG00000196591
TET1 Protein ensembl:ENSG00000168769
TET3 Protein ensembl:ENSG00000182985
TET2 Protein ensembl:ENSG00000168769
YTHDF3 Protein ensembl:ENSG00000185728 YTHDF2 binds to m6A regions to promote degradation of mRNA
EZH2 Protein ensembl:ENSG00000106462

References

  1. YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA. Shi H, Wang X, Lu Z, Zhao BS, Ma H, Hsu PJ, et al. Cell Res. 2017 Mar;27(3):315–28. PubMed Europe PMC Scholia
  2. Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex. Schöller E, Weichmann F, Treiber T, Ringle S, Treiber N, Flatley A, et al. RNA. 2018 Apr;24(4):499–512. PubMed Europe PMC Scholia
  3. Epigenetic deregulation in cancer: Enzyme players and non-coding RNAs. Farooqi AA, Fayyaz S, Poltronieri P, Calin G, Mallardo M. Semin Cancer Biol. 2022 Aug;83:197–207. PubMed Europe PMC Scholia
  4. DNA Methyltransferases in Cancer: Biology, Paradox, Aberrations, and Targeted Therapy. Zhang J, Yang C, Wu C, Cui W, Wang L. Cancers (Basel). 2020 Jul 31;12(8):2123. PubMed Europe PMC Scholia
  5. TET-Mediated Epigenetic Regulation in Immune Cell Development and Disease. Tsiouplis NJ, Bailey DW, Chiou LF, Wissink FJ, Tsagaratou A. Front Cell Dev Biol. 2021 Jan 15;8:623948. PubMed Europe PMC Scholia
  6. The biological function of m6A reader YTHDF2 and its role in human disease. Wang JY, Lu AQ. Cancer Cell Int. 2021 Feb 16;21(1):109. PubMed Europe PMC Scholia
  7. FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell. Relier S, Ripoll J, Guillorit H, Amalric A, Achour C, Boissière F, et al. Nat Commun. 2021 Mar 19;12(1):1716. PubMed Europe PMC Scholia
  8. EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma. Durbin AD, Wang T, Wimalasena VK, Zimmerman MW, Li D, Dharia NV, et al. Cancer Discov. 2022 Mar 1;12(3):730–51. PubMed Europe PMC Scholia
  9. The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases. Chen Z, Zhong X, Xia M, Zhong J. Mol Ther Nucleic Acids. 2021 Nov 4;26:1270–9. PubMed Europe PMC Scholia
  10. Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseases. Yan H, Zhang L, Cui X, Zheng S, Li R. Cell Death Discov. 2022 May 2;8(1):237. PubMed Europe PMC Scholia