Omega-6-fatty acids in senescence (WP5424)
Homo sapiens
Oxylipins, notably prostaglandins, are synthetized by senescent cells and then accumulate, promoting the senescent-associated secretory phenotype (Wiley et al., 2021). Prostaglandins are classified into three main groups, depending on the starting point of their biosynthesis. Series-1 prostaglandins are derived from its precursor dihomo-γ-linolenic acid (DGLA). Series-2 prostaglandins and series-3 prostaglandins are derived from arachidonic acid (AA) and eicosapentaenoic acid (EPA), respectively (Noverr et al., 2003)
Authors
JuliaUM , Andreapascaud , Egon Willighagen , Mra1221 , Denise Slenter , Nikita Krstevska , and Eric WeitzActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
cellular senescence pathway lipid metabolic pathway fatty acid omega degradation pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
15-keto-PGF2α | Metabolite | chebi:28442 | |
Δ12-PGJ2 | Metabolite | chebi:28130 | Synonym: 9-Deoxy-delta(9,12)-13,14-dihydro PGD2 |
12-oxo-10,11-dihydro-LTB4 | Metabolite | hmdb:HMDB0012498 | |
12(S)-HETE | Metabolite | chebi:34146 | |
IP3 | Metabolite | chebi:16595 | |
15(S)-HETE | Metabolite | chebi:15558 | |
15-keto-PGI2 | Metabolite | chebi:15556 | =15-dehydro-Prostaglandin I2 |
10,11-dihydro-LTB4 | Metabolite | hmdb:HMDB0012504 | |
15(R)-HpETE | Metabolite | chebi:82627 | |
PGA2 | Metabolite | chebi:27820 | PGA2=Prostaglandin A2 |
18-COOH-dinor-LTE4 | Metabolite | hmdb:HMDB0012607 | |
10-HOTrE | Metabolite | pubchem.compound:54574843 | |
5(S),6(S)-DiHETE | Metabolite | chebi:53026 | |
HXA3 | Metabolite | chebi:36190 | |
11α-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoic acid | Metabolite | chebi:73965 | |
DH-PGJ2 | Metabolite | chebi:165318 | |
18-COOH-dinor-LTB4 | Metabolite | chebi:63980 | |
Adrenic acid (22:4,w6) | Metabolite | chebi:53487 | |
12-oxo-LTB4 | Metabolite | pubchem.compound:5280876 | |
N-acetyl- LTE4 | Metabolite | chebi:7210 | |
EXC4 | Metabolite | chebi:63984 | |
DH-15d-PGJ2 | Metabolite | pubchem.compound:16061095 | =1a,1b-dihomo-15-deoxy-Δ12,14-prostaglandin J2 |
PGB1 | Metabolite | chebi:27624 | |
TxB1 | Metabolite | pubchem.compound:71668258 | |
Dihomo-y-linolenic acid (20:3,w6) | Metabolite | chebi:53486 | = 8,11,14-Eicosatrienoic acid =DGLA |
LXB4 | Metabolite | lipidmaps:LMFA03040002 | |
15-epi-LXA4 | Metabolite | lipidmaps:LMFA03040010 | |
EXD4 | Metabolite | chebi:63985 | |
PGE1 | Metabolite | chebi:15544 | |
15(S)-HpETE | Metabolite | chebi:15628 | |
Tetracosapentaenoic acid (24:5,w-6) | Metabolite | hmdb:HMDB0006322 | |
Bicyclo-PGE2 | Metabolite | chebi:89568 | |
16-COOH-tetranor-LTE3 | Metabolite | chebi:74014 | |
5(S),6(R)-DiHETE | Metabolite | pubchem.compound:5283160 | |
15-keto-13,14-dihydro-PGE1 | Metabolite | chebi:134499 | |
DH-PGF2α | Metabolite | chebi:183014 | |
EXE4 | Metabolite | chebi:63986 | |
TRXB3 | Metabolite | chebi:35032 | |
13,14-dihydro-15-keto-PGD2 | Metabolite | chebi:72603 | DK-PGD2 |
12(S)-HpETE | Metabolite | chebi:15626 | |
15-epi-LXB4 | Metabolite | lipidmaps:LMFA03040007 | |
PGH2 | Metabolite | chebi:15554 | PGH2 is the abbreviation of PGG2 |
20-COOH-LTB4 | Metabolite | chebi:27562 | |
13,14-dihydro-PGF2α | Metabolite | chebi:88346 | |
5(S)-HETE | Metabolite | chebi:28209 | |
DH-PGD2 | Metabolite | lipidmaps:LMFA03010156 | |
DH-PGE2 | Metabolite | chebi:185711 | |
LGE2 | Metabolite | chebi:34821 | Levuglandin E2 |
LTF4 | Metabolite | chebi:27491 | |
6-trans-LTB4 | Metabolite | chebi:63981 | |
y-linolenic acid (18:3,w6) | Metabolite | chebi:28661 | GLA(18:3 w6) |
Ca2+ | Metabolite | chebi:29108 | |
PGI2 | Metabolite | chebi:15552 | Synonym for PGI2 is 'Prostacyclin' |
LGD2 | Metabolite | chebi:34820 | Levuglandin D2 |
9α,11α-PGF2α | Metabolite | chebi:15553 | |
9α,11β-PGF2α | Metabolite | chebi:15553 | |
13,14-dihydro-15-keto-PGE2 | Metabolite | chebi:15550 | PGEM= Metabolites downstream of PGE2 |
EXA4 | Metabolite | chebi:63983 | |
Eicosadienoic acid (20:2,w6) | Metabolite | chebi:73731 | |
PGG1 | Metabolite | chebi:133739 | |
PGC1 | Metabolite | chebi:15546 | |
Tetranor-PGDM | Metabolite | lipidmaps:LMFA03010221 | |
PGF1α | Metabolite | chebi:28852 | |
TRXA3 | Metabolite | chebi:36203 | |
PGA1 | Metabolite | cas:14152-28-4 | |
Linoleic acid (18:2,w6) | Metabolite | chebi:17351 | LA (18:2 w6) |
cAMP | Metabolite | chebi:17489 | |
15-keto-PGD2 | Metabolite | chebi:15557 | |
HXB3 | Metabolite | chebi:34784 | |
Arachidonic Acid (20:4,w6) | Metabolite | chebi:15843 | |
2,3 dinor-6-keto-PGF1α | Metabolite | chebi:73944 | |
6-keto-PGF1α | Metabolite | chebi:28158 | |
DH-15d-Δ12,14-PGD2 | Metabolite | chebi:165317 | |
5(S),6(S)-epoxy-15(S)-HETE | Metabolite | chebi:64095 | |
13,14-dihydro-15-keto-PGA2 | Metabolite | chebi:89315 | 8: Prostanoid Metabolites as Biomarkers in Human Disease Helena Idborg; Sven-Christian Pawelzik. 2022. PubMed 36005592. |
Ca2+ | Metabolite | chebi:29108 | calcium |
9-deoxy-Δ12-PGD2* | Metabolite | chebi:175297 | |
15-keto-13,14-dihydro-PGF2α | Metabolite | chebi:63976 | |
LXA4 | Metabolite | lipidmaps:LMFA03040001 | |
11-dehydro-TxB2 | Metabolite | chebi:28667 | |
6-keto-PGE1 | Metabolite | chebi:28269 | |
PGE2 | Metabolite | chebi:15551 | |
Osbond acid (22:5,w6) | Metabolite | chebi:53488 | =docosapentaenoic acid (DPAω6, 22:5) |
Tetracosatetraenoic acid (24:4, w-6) | Metabolite | hmdb:HMDB0006246 | |
20-COOH-LTE4 | Metabolite | pubchem.compound:53481508 | |
19-OH-PGE1 | Metabolite | cas:55123-67-6 | |
PGD2 | Metabolite | chebi:15555 | |
PGH1 | Metabolite | chebi:91133 | |
PGJ2 | Metabolite | chebi:27485 | |
15-keto-PGE1 | Metabolite | cas:22973-19-9 | |
PGD1 | Metabolite | chebi:27696 | |
TxA | Metabolite | chebi:15627 | |
PGG2 | Metabolite | chebi:27647 | Prostaglandin G2 is abbreviated as PGG2 |
Δ6-trans-12-epi-LTB4 | Metabolite | chebi:63982 | |
15-deoxy-Δ12,14-PGJ2 | Metabolite | chebi:34159 | =15d-PGJ2 |
19-OH-PGE2 | Metabolite | chebi:165313 | |
15-keto-PGE2 | Metabolite | chebi:15547 | |
PGC2 | Metabolite | chebi:27555 | PGC2=Prostaglandin C2 |
PGB2 | Metabolite | chebi:28099 | PGB2=Prostaglandin B2 |
TxB | Metabolite | chebi:28728 | |
cAMP | Metabolite | chebi:17489 | PGI2 binding to the associated IP receptor (coupled to Gs) leads to an activation of the AC and thus to an increase of intracellular cAMP. Its elevation downregulates store-mediated calcium entry, calcium mobilization and secretion, as well as platelet adhesion to subendothelial collagen via integrin α2β1. The cAMP increase further results in an activation of protein kinase-A (PKA) and in principle, in an inhibition of platelet activation. Analogous to cAMP, PKA activity has been associated with a reduced Ca2+ release from intra-platelet stores |
Membrane phospholipids | Metabolite | chebi:16247 | |
19-OH-6-keto-PGF1α | Metabolite | chebi:172589 | |
6,15-Diketo-13,14-dihydro-PGF1α | Metabolite | chebi:72595 | |
2,3-dinor-11β-PGF2α | Metabolite | chebi:165323 | |
2,3-Dinor-TxB2 | Metabolite | chebi:89991 | |
15-deoxy-Δ12,14-PGD2 | Metabolite | chebi:63999 | =15d-PGJ2 |
LTB4 | Metabolite | chebi:15647 | |
5(S)-HpETE | Metabolite | hmdb:HMDB11135 | |
LTD4 | Metabolite | chebi:28666 | |
LTA4 | Metabolite | chebi:15651 | |
LTE4 | Metabolite | chebi:15650 | |
LTC4 | Metabolite | chebi:16978 | |
DH-PGI2 | Metabolite | chebi:165328 | |
ROS | Metabolite | chebi:26523 | |
20-OH-LTB4 | Metabolite | chebi:15646 | |
8-iso-15-keto-PGF2α | Metabolite | chebi:175523 | |
2,3-dinor-8-IsoPGF2α | Metabolite | pubchem.compound:9548881 | |
8-iso-13,14-dihydro-15-keto-PGF2α | Metabolite | lipidmaps:LMFA03110004 | |
15-F2-IsoP | Metabolite | chebi:187201 | = 8-iso-PGF2a |
15-D2-IsoP | Metabolite | lipidmaps:LMFA03110099 | Iso-Prostaglandin H2 |
15-J2-IsoP | Metabolite | lipidmaps:LMFA03110101 | Iso-Prostaglandin H2 |
15-A2-IsoP | Metabolite | lipidmaps:LMFA03110138 | Iso-Prostaglandin H2 |
12-F2-IsoP | Metabolite | lipidmaps:LMFA03110042 | Iso-Prostaglandin H2 |
12-D2-IsoP | Metabolite | lipidmaps:LMFA03110085 | Iso-Prostaglandin H2 |
12-J2-IsoP | Metabolite | lipidmaps:LMFA03110087 | Iso-Prostaglandin H2 |
12-15d-J2-IsoP | Metabolite | lipidmaps:LMFA03110090 | Iso-Prostaglandin H2 |
12-E2-IsoP | Metabolite | lipidmaps:LMFA03110190 | Iso-Prostaglandin H2 |
12-A2-IsoP | Metabolite | lipidmaps:LMFA03110248 | Iso-Prostaglandin H2 |
8-F2-IsoP | Metabolite | lipidmaps:8-F2t-IsoP | |
8-D2-IsoP | Metabolite | lipidmaps:LMFA03110057 | Iso-Prostaglandin H2 |
8-J2-IsoP | Metabolite | lipidmaps:LMFA03110059 | Iso-Prostaglandin H2 |
8-15d-J2-IsoP | Metabolite | lipidbank:LMFA03110062 | Iso-Prostaglandin H2 |
8-E2-IsoP | Metabolite | lipidmaps:LMFA03110003 | Iso-Prostaglandin H2 |
5-F2-IsoP | Metabolite | lipidmaps:LMFA03110039 | Iso-Prostaglandin H2 |
5-D2-IsoP | Metabolite | lipidmaps:LMFA03110070 | Iso-Prostaglandin H2 |
5-J2-IsoP | Metabolite | lipidmaps:LMFA03110072 | Iso-Prostaglandin H2 |
5-15d-J2-IsoP | Metabolite | lipidmaps:LMFA03110075 | Iso-Prostaglandin H2 |
5-E2-IsoP | Metabolite | lipidmaps:LMFA03110174 | Iso-Prostaglandin H2 |
5-A2-IsoP | Metabolite | lipidmaps:LMFA03110257 | Iso-Prostaglandin H2 |
7-DH-F2-IsoP | Metabolite | lipidmaps:LMFA03110299 | |
14-DH-F2-IsoP | Metabolite | lipidmaps:LMFA03110331 | |
10-DH-F2-IsoP | Metabolite | lipidmaps:LMFA03110315 | |
17-DH-F2-IsoP | Metabolite | lipidmaps:LMFA03110347 | |
11-deoxy-13,14-dihydro-15-keto-11β,16-cyclo-PGE1 | Metabolite | cas:1283861-32-4 | |
Δ13-reductase | GeneProduct | ensembl:ENSG00000140043 | =15-oxoprostaglandin-Δ13-reductase |
p53 | GeneProduct | ensembl:ENSG00000141510 | |
CYP4F8 | GeneProduct | ensembl:ENSG00000186526 | |
PTGES | GeneProduct | ensembl:ENSG00000148344 | =microsomal prostaglandin E synthase 1 (mPGES-1) |
PGFS | GeneProduct | ensembl:ENSG00000157870 | =Prostaglandin F synthase |
15-ketoprostaglandin reductase | GeneProduct | ensembl:ENSG00000140043 | |
NAT1 | GeneProduct | ensembl:ENSG00000171428 | |
ALOX15 | GeneProduct | ensembl:ENSG00000161905 | |
SLCO2A1 | GeneProduct | ensembl:ENSG00000174640 | |
PGES | GeneProduct | ensembl:ENSG00000148344 | =prostaglandin E synthase |
γ-GT | GeneProduct | ensembl:ENSG00000100031 | Identical to GGT1 |
TBXAS1 | GeneProduct | ensembl:ENSG00000059377 | =CYP5A1 |
Carboxypeptidase A | GeneProduct | eccode:3.4.17.1 | |
GPX1 | GeneProduct | ensembl:ENSG00000233276 | |
ALOXE3 | GeneProduct | ensembl:ENSG00000179148 | |
2,4-dienoyl-CoA reductase | GeneProduct | ensembl:ENSG00000104325 | |
EPHX2 | GeneProduct | ensembl:ENSG00000120915 | |
PGDS | GeneProduct | ensembl:ENSG00000107317 | =Prostaglandin D synthase |
ABCC4 | GeneProduct | ensembl:ENSG00000125257 | |
PG-9KR | GeneProduct | ensembl:ENSG00000159228 | PG-9KR= Prostaglandin-9-ketoreductase |
DPEP | GeneProduct | eccode:1.3.4.13 | |
AKR1C3 | GeneProduct | ensembl:ENSG00000196139 | =aldo-keto reductase family 1 member C3 |
CYP4F8 | GeneProduct | ensembl:ENSG00000186526 | |
H-PGDS | GeneProduct | ensembl:ENSG00000163106 | |
PGDS | GeneProduct | ensembl:ENSG00000107317 | |
PGE synthase | GeneProduct | ensembl:ENSG00000148344 | |
TXAS | GeneProduct | ensembl:ENSG00000059377 | =Thromboxane synthase |
CYP4F8 | GeneProduct | ensembl:ENSG00000186526 | =cytochrome P450 family 4 subfamily F member 8 |
LTC4S | GeneProduct | ensembl:ENSG00000213316 | |
NAT2 | GeneProduct | ensembl:ENSG00000156006 | |
ALOX15B | GeneProduct | ensembl:ENSG00000179593 | |
p21 | GeneProduct | ensembl:ENSG00000124762 | |
PGES | GeneProduct | ensembl:ENSG00000148344 | =Prostaglandin E synthase |
ALOX12 | GeneProduct | ensembl:ENSG00000108839 | |
HPGD | GeneProduct | ensembl:ENSG00000164120 | 15-PGDH=15-hydroxy-prostaglandin dehydrogenase |
L-PGDS | GeneProduct | ensembl:ENSG00000107317 | |
CYP8A1 | GeneProduct | ensembl:ENSG00000124212 | =prostaglandin I2 synthase =PTGIS |
AKR1B1 | GeneProduct | ensembl:ENSG00000085662 | |
AKR1C3 | GeneProduct | ensembl:ENSG00000196139 | =NADPH-dependent PGD2 11-ketoreductase =aldo-keto reductase family 1 member C3 =EC 1.1.1.188 |
GSTP1 | GeneProduct | ensembl:ENSG00000084207 | |
GGT1 | GeneProduct | ensembl:ENSG00000100031 | |
PTGES2 | GeneProduct | ensembl:ENSG00000148334 | =microsomal prostaglandin E synthase 2 (PTGES2) |
PTGES3 | GeneProduct | ensembl:ENSG00000110958 | =prostaglandin E synthase 3 (cPGES) |
AKR1B1 | GeneProduct | ensembl:ENSG00000085662 | =aldo-keto reductase family 1 member B |
p38 MAPK | GeneProduct | ensembl:ENSG00000185386 | |
11-hydroxythromboxane B2 dehydrogenase | GeneProduct | ensembl:ENSG00000165092 | 11-hydroxythromboxane B2 dehydrogenase is the same as cytosolic aldehyde dehydrogenase |
PTGS1 | GeneProduct | ensembl:ENSG00000095303 | Prostaglandin-endoperoxide synthase 1 =cyclooxygenase (COX) |
PTGS2 | GeneProduct | ensembl:ENSG00000073756 | prostaglandin-endoperoxide synthase 2 =cyclooxygenase (COX) |
ELOVL2 | GeneProduct | ensembl:ENSG00000197977 | fatty acid elongase 2 |
ELOVL5 | GeneProduct | ensembl:ENSG00000012660 | fatty acid elongase 5 |
FADS2 | GeneProduct | ensembl:ENSG00000134824 | gene=FADS2 Δ6-Desaturase |
FADS1 | GeneProduct | ensembl:ENSG00000149485 | Δ5-Desaturase |
Δ13-reductase | GeneProduct | ensembl:ENSG00000140043 | =15-oxo-prostaglandin Δ13-reductase |
Δ13-reductase | GeneProduct | eccode:1.3.1.48 | =15-oxoprostaglandin-Δ13-reductase |
DPEP1 | GeneProduct | ensembl:ENSG00000015413 | =Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11] |
DPEP2 | GeneProduct | ensembl:ENSG00000167261 | |
GGT5 | GeneProduct | ensembl:ENSG00000099998 | =gamma-glutamyltransferase 5 |
LTA4H | GeneProduct | ensembl:ENSG00000111144 | |
ALOX5 | GeneProduct | ensembl:ENSG00000012779 | =arachidonate 5-lipoxygenase |
FLAP | GeneProduct | ensembl:ENSG00000132965 | gene = ALOX5AP FLAP= 5-lipoxygenase activating protein |
SIRT1 | GeneProduct | ensembl:ENSG00000096717 | |
p53 | GeneProduct | ensembl:ENSG00000141510 | Gene: TP53 |
p21 | GeneProduct | ensembl:ENSG00000124762 | Gene: CDKN1A |
Rb | GeneProduct | ensembl:ENSG00000139687 | |
PTGS2 | GeneProduct | ensembl:ENSG00000073756 | |
GSH | Protein | kegg.genes:C00051 | Cofactor |
Cytosolic phospholipase A2 | Protein | uniprot:P47712 | |
CysLT1R | Protein | ensembl:ENSG00000173198 | =cysteinyl leukotriene type 1 receptor |
PAI-1 | Protein | ensembl:ENSG00000106366 | Gene: SERPINE1 |
References
- Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. Ohki S, Ogino N, Yamamoto S, Hayaishi O. J Biol Chem. 1979 Feb 10;254(3):829–36. PubMed Europe PMC Scholia
- Metabolism of prostaglandins E, A, and C in serum. Polet H, Levine L. J Biol Chem. 1975 Jan 25;250(2):351–7. PubMed Europe PMC Scholia
- Letting the computer do the work. Sparks SM. Am J Nurs. 1978 Apr;78(4):645–7. PubMed Europe PMC Scholia
- Recirculation of prostacyclin (PGI2) in the dog. Dusting GJ, Moncada S, Vane JR. Br J Pharmacol. 1978 Oct;64(2):315–20. PubMed Europe PMC Scholia
- Introduction to the biosynthesis and metabolism of prostaglandins. Piper PJ. Postgrad Med J. 1977 Nov;53(625):643–6. PubMed Europe PMC Scholia
- Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. Miyamoto T, Ogino N, Yamamoto S, Hayaishi O. J Biol Chem. 1976 May 10;251(9):2629–36. PubMed Europe PMC Scholia
- On the metabolism of prostaglandin E1 administered intravenously to human volunteers. Peskar BA, Cawello W, Rogatti W, Rudofsky G. J Physiol Pharmacol. 1991 Sep;42(3):327–31. PubMed Europe PMC Scholia
- Effect of dietary calcium on renal prostaglandins. Katayama S, Maruno Y, Itabashi A, Inaba M, Akabane S, Tanaka K, et al. Prostaglandins Leukot Essent Fatty Acids. 1991 Mar;42(3):197–200. PubMed Europe PMC Scholia
- Leukotriene E4 elimination and metabolism in normal human subjects. Sala A, Voelkel N, Maclouf J, Murphy RC. J Biol Chem. 1990 Dec 15;265(35):21771–8. PubMed Europe PMC Scholia
- Prostaglandin E2 metabolism in the human fetal membranes. Cheung PY, Challis JR. Am J Obstet Gynecol. 1989 Dec;161(6 Pt 1):1580–5. PubMed Europe PMC Scholia
- Eicosanoid nomenclature. Smith W. Prostaglandins. 1989 Jul;38(1):125–33. PubMed Europe PMC Scholia
- Purification and characterization of human microsomal dipeptidase. Adachi H, Kubota I, Okamura N, Iwata H, Tsujimoto M, Nakazato H, et al. J Biochem. 1989 Jun;105(6):957–61. PubMed Europe PMC Scholia
- Metabolism of leukotrienes. Hammarström S, Orning L, Bernström K. Mol Cell Biochem. 1985 Nov;69(1):7–16. PubMed Europe PMC Scholia
- Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. Watanabe K, Iguchi Y, Iguchi S, Arai Y, Hayaishi O, Roberts LJ 2nd. Proc Natl Acad Sci U S A. 1986 Mar;83(6):1583–7. PubMed Europe PMC Scholia
- Identification of 11-dehydro-TXB2 as a suitable parameter for monitoring thromboxane production in the human. Westlund P, Granström E, Kumlin M, Nordenström A. Prostaglandins. 1986 May;31(5):929–60. PubMed Europe PMC Scholia
- Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans. Liston TE, Roberts LJ 2nd. Proc Natl Acad Sci U S A. 1985 Sep;82(18):6030–4. PubMed Europe PMC Scholia
- 6-Keto prostaglandin F1 alpha production in endothelial-cell cultures in response to normal and diabetic human serum. Patel MK, Evans CE, McEvoy FA. Biosci Rep. 1983 Jan;3(1):53–60. PubMed Europe PMC Scholia
- Clinical pharmacology and potential of prostacyclin. Lewis PJ, Dollery CT. Br Med Bull. 1983 Jul;39(3):281–4. PubMed Europe PMC Scholia
- Review: 6 keto-prostaglandin-E1. Moore PK, Griffiths RJ. Prostaglandins. 1983 Oct;26(4):509–17. PubMed Europe PMC Scholia
- Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. Fitzpatrick FA, Wynalda MA. J Biol Chem. 1983 Oct 10;258(19):11713–8. PubMed Europe PMC Scholia
- Formation and metabolism of prostaglandins in the kidney. Anggård E, Oliw E. Kidney Int. 1981 Jun;19(6):771–80. PubMed Europe PMC Scholia
- Dihomo-prostaglandins and -thromboxane. A prostaglandin family from adrenic acid that may be preferentially synthesized in the kidney. Sprecher H, VanRollins M, Sun F, Wyche A, Needleman P. J Biol Chem. 1982 Apr 10;257(7):3912–8. PubMed Europe PMC Scholia
- 6-keto PGE1: a possible metabolite of prostacyclin having platelet antiaggregatory effects. Quilley CP, McGiff JC, Lee WH, Sun FF, Wong PY. Hypertension. 1980;2(4):524–8. PubMed Europe PMC Scholia
- Metabolism of prostacyclin by 9-hydroxyprostaglandin dehydrogenase in human platelets. Formation of a potent inhibitor of platelet aggregation and enzyme purification. Wong PY, Lee WH, Chao PH, Reiss RF, McGiff JC. J Biol Chem. 1980 Oct 10;255(19):9021–4. PubMed Europe PMC Scholia
- Metabolism of prostacyclin and 6-keto-prostaglandin F1 alpha in man. Rosenkranz B, Fischer C, Weimer KE, Frölich JC. J Biol Chem. 1980 Nov 10;255(21):10194–8. PubMed Europe PMC Scholia
- Prostacyclin production during pregnancy: comparison of production during normal pregnancy and pregnancy complicated by hypertension. Goodman RP, Killam AP, Brash AR, Branch RA. Am J Obstet Gynecol. 1982 Apr 1;142(7):817–22. PubMed Europe PMC Scholia
- Radioimmunologic determination of 15-keto-13,14-dihydro-PGE2: a method for its stable degradation product, 11-deoxy-15-keto-13,14-dihydro-11 beta, 16 xi-cyclo-PGE2. Granström E, Fitzpatrick FA, Kindahl H. Methods Enzymol. 1982;86:306–20. PubMed Europe PMC Scholia
- The stability of 13,14-dihydro-15 keto-PGE2. Fitzpatrick FA, Aguirre R, Pike JE, Lincoln FH. Prostaglandins. 1980 Jun;19(6):917–31. PubMed Europe PMC Scholia
- Feminism, social policy, and long-acting contraception. Nelson HL, Nelson JL. Hastings Cent Rep. 1995;25(1):S30-2. PubMed Europe PMC Scholia
- Prostaglandin B2-induced pulmonary hypertension is mediated by TxA2/PGH2 receptor stimulation. Liu F, Orr JA, Wu JY. Am J Physiol. 1994 Nov;267(5 Pt 1):L602-8. PubMed Europe PMC Scholia
- Identification of 19 (R)-OH prostaglandin E2 as a selective prostanoid EP2-receptor agonist. Woodward DF, Protzman CE, Krauss AH, Williams LS. Prostaglandins. 1993 Oct;46(4):371–83. PubMed Europe PMC Scholia
- Prostaglandin-metabolizing enzymes during pregnancy: characterization of NAD(+)-dependent prostaglandin dehydrogenase, carbonyl reductase, and cytochrome P450-dependent prostaglandin omega-hydroxylase. Okita RT, Okita JR. Crit Rev Biochem Mol Biol. 1996 Apr;31(2):101–26. PubMed Europe PMC Scholia
- Biological actions of delta 12-prostaglandin J2. Negishi M, Koizumi T, Ichikawa A. J Lipid Mediat Cell Signal. 1995 Oct;12(2–3):443–8. PubMed Europe PMC Scholia
- p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2. Kramer RM, Roberts EF, Um SL, Börsch-Haubold AG, Watson SP, Fisher MJ, et al. J Biol Chem. 1996 Nov 1;271(44):27723–9. PubMed Europe PMC Scholia
- In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis. Leonhardt A, Krauss M, Gieler U, Schweer H, Happle R, Seyberth HW. Br J Dermatol. 1997 Mar;136(3):337–40. PubMed Europe PMC Scholia
- Levuglandin E2-protein adducts in human plasma and vasculature. Salomon RG, Subbanagounder G, O’Neil J, Kaur K, Smith MA, Hoff HF, et al. Chem Res Toxicol. 1997 May;10(5):536–45. PubMed Europe PMC Scholia
- Evidence for the formation of F3-isoprostanes during peroxidation of eicosapentaenoic acid. Nourooz-Zadeh J, Halliwell B, Anggård EE. Biochem Biophys Res Commun. 1997 Jul 18;236(2):467–72. PubMed Europe PMC Scholia
- Measurements of urinary prostaglandins in young ovulatory women during the menstrual cycle and in postmenopausal women. Farker K, Schweer H, Vollandt R, Nassr N, Nagel U, Seyberth HW, et al. Prostaglandins. 1997 Sep;54(3):655–64. PubMed Europe PMC Scholia
- Metabolism of 8-iso-prostaglandin F2alpha. Basu S. FEBS Lett. 1998 May 22;428(1–2):32–6. PubMed Europe PMC Scholia
- Effects of prostaglandin E1 metabolites on the induction of arterial thromboresistance. Sinzinger H, Neumann I, O’Grady J, Rogatti W, Peskar BA. Prostaglandins Other Lipid Mediat. 1998 Apr;55(5–6):265–75. PubMed Europe PMC Scholia
- Radioimmunoassay of 8-iso-prostaglandin F2alpha: an index for oxidative injury via free radical catalysed lipid peroxidation. Basu S. Prostaglandins Leukot Essent Fatty Acids. 1998 Apr;58(4):319–25. PubMed Europe PMC Scholia
- Endogenous glutathione conjugates: occurrence and biological functions. Wang W, Ballatori N. Pharmacol Rev. 1998 Sep;50(3):335–56. PubMed Europe PMC Scholia
- cDNA cloning, expression and characterization of human prostaglandin F synthase. Suzuki-Yamamoto T, Nishizawa M, Fukui M, Okuda-Ashitaka E, Nakajima T, Ito S, et al. FEBS Lett. 1999 Dec 3;462(3):335–40. PubMed Europe PMC Scholia
- Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes. Nishizawa M, Nakajima T, Yasuda K, Kanzaki H, Sasaguri Y, Watanabe K, et al. Genes Cells. 2000 Feb;5(2):111–25. PubMed Europe PMC Scholia
- Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides. Bylund J, Hidestrand M, Ingelman-Sundberg M, Oliw EH. J Biol Chem. 2000 Jul 21;275(29):21844–9. PubMed Europe PMC Scholia
- Prostaglandin E2 synthesis and metabolism in burn injury and trauma. Hahn EL, Gamelli RL. J Trauma. 2000 Dec;49(6):1147–54. PubMed Europe PMC Scholia
- Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Straus DS, Glass CK. Med Res Rev. 2001 May;21(3):185–210. PubMed Europe PMC Scholia
- Determination of 9alpha, 11beta prostaglandin F2 in human urine. combination of solid-phase extraction and radioimmunoassay. Mucha, Riutta A. Prostaglandins Leukot Essent Fatty Acids. 2001;65(5–6):271–80. PubMed Europe PMC Scholia
- Polyunsaturated fatty acid synthesis: what will they think of next? Wallis JG, Watts JL, Browse J. Trends Biochem Sci. 2002 Sep;27(9):467. PubMed Europe PMC Scholia
- Prostaglandin F synthase. Watanabe K. Prostaglandins Other Lipid Mediat. 2002 Aug;68–69:401–7. PubMed Europe PMC Scholia
- Carboxypeptidase A-catalyzed direct conversion of leukotriene C4 to leukotriene F4. Reddanna P, Prabhu KS, Whelan J, Reddy CC. Arch Biochem Biophys. 2003 May 15;413(2):158–63. PubMed Europe PMC Scholia
- Identification of two additional members of the membrane-bound dipeptidase family. Habib GM, Shi ZZ, Cuevas AA, Lieberman MW. FASEB J. 2003 Jul;17(10):1313–5. PubMed Europe PMC Scholia
- Identification of a novel class of endoperoxides from arachidonate autoxidation. Yin H, Morrow JD, Porter NA. J Biol Chem. 2004 Jan 30;279(5):3766–76. PubMed Europe PMC Scholia
- Prostaglandin synthases: recent developments and a novel hypothesis. Helliwell RJA, Adams LF, Mitchell MD. Prostaglandins Leukot Essent Fatty Acids. 2004 Feb;70(2):101–13. PubMed Europe PMC Scholia
- 5-Lipoxygenase Pathway, Dendritic Cells, and Adaptive Immunity. Hedi H, Norbert G. J Biomed Biotechnol. 2004;2004(2):99–105. PubMed Europe PMC Scholia
- Increased urinary F(2)-isoprostanes levels in the patients with Alzheimer’s disease. Kim KM, Jung BH, Paeng KJ, Kim I, Chung BC. Brain Res Bull. 2004 Jul 30;64(1):47–51. PubMed Europe PMC Scholia
- 5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation. Catalano A, Rodilossi S, Caprari P, Coppola V, Procopio A. EMBO J. 2005 Jan 12;24(1):170–9. PubMed Europe PMC Scholia
- Distinguishing levuglandins produced through the cyclooxygenase and isoprostane pathways. Salomon RG. Chem Phys Lipids. 2005 Mar;134(1):1–20. PubMed Europe PMC Scholia
- On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens. Stark K, Bylund J, Törmä H, Sahlén G, Oliw EH. Prostaglandins Other Lipid Mediat. 2005 Jan;75(1–4):47–64. PubMed Europe PMC Scholia
- Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes. Gazi L, Gyles S, Rose J, Lees S, Allan C, Xue L, et al. Prostaglandins Other Lipid Mediat. 2005 Jan;75(1–4):153–67. PubMed Europe PMC Scholia
- Urinary 8-epi-PGF2alpha and its endogenous beta-oxidation products (2,3-dinor and 2,3-dinor-5,6-dihydro) as biomarkers of total body oxidative stress. Nourooz-Zadeh J, Cooper MB, Ziegler D, Betteridge DJ. Biochem Biophys Res Commun. 2005 May 13;330(3):731–6. PubMed Europe PMC Scholia
- Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2. Sampey AV, Monrad S, Crofford LJ. Arthritis Res Ther. 2005;7(3):114–7. PubMed Europe PMC Scholia
- The biochemistry of the isoprostane, neuroprostane, and isofuran Pathways of lipid peroxidation. Roberts LJ 2nd, Fessel JP, Davies SS. Brain Pathol. 2005 Apr;15(2):143–8. PubMed Europe PMC Scholia
- Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases. Park JY, Pillinger MH, Abramson SB. Clin Immunol. 2006 Jun;119(3):229–40. PubMed Europe PMC Scholia
- Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Kortlever RM, Higgins PJ, Bernards R. Nat Cell Biol. 2006 Aug;8(8):877–84. PubMed Europe PMC Scholia
- Arachidonate-derived dihomoprostaglandin production observed in endotoxin-stimulated macrophage-like cells. Harkewicz R, Fahy E, Andreyev A, Dennis EA. J Biol Chem. 2007 Feb 2;282(5):2899–910. PubMed Europe PMC Scholia
- Novel cyclooxygenase-catalyzed bioactive prostaglandin F2alpha from physiology to new principles in inflammation. Basu S. Med Res Rev. 2007 Jul;27(4):435–68. PubMed Europe PMC Scholia
- Metabolism of adrenic acid to vasodilatory 1alpha,1beta-dihomo-epoxyeicosatrienoic acids by bovine coronary arteries. Yi XY, Gauthier KM, Cui L, Nithipatikom K, Falck JR, Campbell WB. Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2265-74. PubMed Europe PMC Scholia
- PRAK is essential for ras-induced senescence and tumor suppression. Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, et al. Cell. 2007 Jan 26;128(2):295–308. PubMed Europe PMC Scholia
- Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. Chou WL, Chuang LM, Chou CC, Wang AHJ, Lawson JA, FitzGerald GA, et al. J Biol Chem. 2007 Jun 22;282(25):18162–72. PubMed Europe PMC Scholia
- Normal or stress-induced fibroblast senescence involves COX-2 activity. Zdanov S, Bernard D, Debacq-Chainiaux F, Martien S, Gosselin K, Vercamer C, et al. Exp Cell Res. 2007 Aug 15;313(14):3046–56. PubMed Europe PMC Scholia
- Biosynthesis and metabolism of leukotrienes. Murphy RC, Gijón MA. Biochem J. 2007 Aug 1;405(3):379–95. PubMed Europe PMC Scholia
- Membrane prostaglandin E synthase-1: a novel therapeutic target. Samuelsson B, Morgenstern R, Jakobsson PJ. Pharmacol Rev. 2007 Sep;59(3):207–24. PubMed Europe PMC Scholia
- Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. Song WL, Wang M, Ricciotti E, Fries S, Yu Y, Grosser T, et al. J Biol Chem. 2008 Jan 11;283(2):1179–88. PubMed Europe PMC Scholia
- Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. Feltenmark S, Gautam N, Brunnström A, Griffiths W, Backman L, Edenius C, et al. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):680–5. PubMed Europe PMC Scholia
- Human biochemistry of the isoprostane pathway. Milne GL, Yin H, Morrow JD. J Biol Chem. 2008 Jun 6;283(23):15533–7. PubMed Europe PMC Scholia
- Isoprostanes and phytoprostanes: Bioactive lipids. Durand T, Bultel-Poncé V, Guy A, El Fangour S, Rossi JC, Galano JM. Biochimie. 2011 Jan;93(1):52–60. PubMed Europe PMC Scholia
- Nonenzymatic free radical-catalyzed generation of 15-deoxy-Δ(12,14)-prostaglandin J₂-like compounds (deoxy-J₂-isoprostanes) in vivo. Hardy KD, Cox BE, Milne GL, Yin H, Roberts LJ 2nd. J Lipid Res. 2011 Jan;52(1):113–24. PubMed Europe PMC Scholia
- Catalytic mechanism of the primary human prostaglandin F2α synthase, aldo-keto reductase 1B1--prostaglandin D2 synthase activity in the absence of NADP(H). Nagata N, Kusakari Y, Fukunishi Y, Inoue T, Urade Y. FEBS J. 2011 Apr;278(8):1288–98. PubMed Europe PMC Scholia
- p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. Freund A, Patil CK, Campisi J. EMBO J. 2011 Apr 20;30(8):1536–48. PubMed Europe PMC Scholia
- Eicosadienoic acid differentially modulates production of pro-inflammatory modulators in murine macrophages. Huang YS, Huang WC, Li CW, Chuang LT. Mol Cell Biochem. 2011 Dec;358(1–2):85–94. PubMed Europe PMC Scholia
- Generation and detection of levuglandins and isolevuglandins in vitro and in vivo. Zhang M, Li W, Li T. Molecules. 2011 Jun 24;16(7):5333–48. PubMed Europe PMC Scholia
- Isoprostane generation and function. Milne GL, Yin H, Hardy KD, Davies SS, Roberts LJ 2nd. Chem Rev. 2011 Oct 12;111(10):5973–96. PubMed Europe PMC Scholia
- Prostaglandin E2 EP receptors as therapeutic targets in breast cancer. Reader J, Holt D, Fulton A. Cancer Metastasis Rev. 2011 Dec;30(3–4):449–63. PubMed Europe PMC Scholia
- Multiple roles of dihomo-γ-linolenic acid against proliferation diseases. Wang X, Lin H, Gu Y. Lipids Health Dis. 2012 Feb 14;11:25. PubMed Europe PMC Scholia
- Functional analysis of human thromboxane synthase polymorphic variants. Chen CYK, Poole EM, Ulrich CM, Kulmacz RJ, Wang LH. Pharmacogenet Genomics. 2012 Sep;22(9):653–8. PubMed Europe PMC Scholia
- Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia. Anyona SB, Kempaiah P, Davenport GC, Vulule JM, Hittner JB, Ong’echa JM, et al. Biochem Biophys Res Commun. 2013 Jul 12;436(4):585–90. PubMed Europe PMC Scholia
- Lipidomics of essential fatty acids and oxygenated metabolites. Lagarde M, Bernoud-Hubac N, Calzada C, Véricel E, Guichardant M. Mol Nutr Food Res. 2013 Aug;57(8):1347–58. PubMed Europe PMC Scholia
- Cellular senescence involves an intracrine prostaglandin E2 pathway in human fibroblasts. Martien S, Pluquet O, Vercamer C, Malaquin N, Martin N, Gosselin K, et al. Biochim Biophys Acta. 2013 Jul;1831(7):1217–27. PubMed Europe PMC Scholia
- Prostaglandin E2 regulates its own inactivating enzyme, 15-PGDH, by EP2 receptor-mediated cervical cell-specific mechanisms. Kishore AH, Owens D, Word RA. J Clin Endocrinol Metab. 2014 Mar;99(3):1006–18. PubMed Europe PMC Scholia
- The isoprostanes--25 years later. Milne GL, Dai Q, Roberts LJ 2nd. Biochim Biophys Acta. 2015 Apr;1851(4):433–45. PubMed Europe PMC Scholia
- 15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂ as an electrophilic mediator. Shibata T. Biosci Biotechnol Biochem. 2015;79(7):1044–9. PubMed Europe PMC Scholia
- On the biosynthesis of 15-HETE and eoxin C4 by human airway epithelial cells. Brunnström Å, Tryselius Y, Feltenmark S, Andersson E, Leksell H, James A, et al. Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt A):83–90. PubMed Europe PMC Scholia
- Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs. Gabbs M, Leng S, Devassy JG, Monirujjaman M, Aukema HM. Adv Nutr. 2015 Sep 15;6(5):513–40. PubMed Europe PMC Scholia
- Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration. Figueiredo-Pereira ME, Corwin C, Babich J. Ann N Y Acad Sci. 2016 Jan;1363(1):125–37. PubMed Europe PMC Scholia
- 8-iso-prostaglandin-F2α: a possible trigger or accelerator of diabetic retinopathy. Zhang Y, Du Y, He JF, Li KJ. Int J Ophthalmol. 2016 Jan 18;9(1):163–5. PubMed Europe PMC Scholia
- 15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury. Yao L, Chen W, Song K, Han C, Gandhi CR, Lim K, et al. PLoS One. 2017 Apr 19;12(4):e0176106. PubMed Europe PMC Scholia
- Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25years of research in chemistry and biology. Galano JM, Lee YY, Oger C, Vigor C, Vercauteren J, Durand T, et al. Prog Lipid Res. 2017 Oct;68:83–108. PubMed Europe PMC Scholia
- Hallmarks of Cellular Senescence. Hernandez-Segura A, Nehme J, Demaria M. Trends Cell Biol. 2018 Jun;28(6):436–53. PubMed Europe PMC Scholia
- Leukotriene D4 induces cellular senescence in osteoblasts. Wei J, Chen S, Guo W, Feng B, Yang S, Huang C, et al. Int Immunopharmacol. 2018 May;58:154–9. PubMed Europe PMC Scholia
- Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance - A review. Saini RK, Keum YS. Life Sci. 2018 Jun 15;203:255–67. PubMed Europe PMC Scholia
- Arachidonic acid: Physiological roles and potential health benefits - A review. Tallima H, El Ridi R. J Adv Res. 2017 Nov 24;11:33–41. PubMed Europe PMC Scholia
- A polymorphism in the fatty acid desaturase-2 gene is associated with the arachidonic acid metabolism in pigs. Gol S, Pena RN, Rothschild MF, Tor M, Estany J. Sci Rep. 2018 Sep 25;8(1):14336. PubMed Europe PMC Scholia
- 5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. Green AR, Freedman C, Tena J, Tourdot BE, Liu B, Holinstat M, et al. Biochemistry. 2018 Dec 4;57(48):6726–34. PubMed Europe PMC Scholia
- FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health. Koletzko B, Reischl E, Tanjung C, Gonzalez-Casanova I, Ramakrishnan U, Meldrum S, et al. Annu Rev Nutr. 2019 Aug 21;39:21–44. PubMed Europe PMC Scholia
- 15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism. Li J, Guo C, Wu J. PPAR Res. 2019 Aug 1;2019:7242030. PubMed Europe PMC Scholia
- Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis. Wiley CD, Brumwell AN, Davis SS, Jackson JR, Valdovinos A, Calhoun C, et al. JCI Insight. 2019 Dec 19;4(24):e130056. PubMed Europe PMC Scholia
- Measurement of Thromboxane Biosynthesis in Health and Disease. Patrono C, Rocca B. Front Pharmacol. 2019 Oct 30;10:1244. PubMed Europe PMC Scholia
- Lipid Mediators Regulate Pulmonary Fibrosis: Potential Mechanisms and Signaling Pathways. Suryadevara V, Ramchandran R, Kamp DW, Natarajan V. Int J Mol Sci. 2020 Jun 15;21(12):4257. PubMed Europe PMC Scholia
- Moving forward with isoprostanes, neuroprostanes and phytoprostanes: where are we now? Ahmed OS, Galano JM, Pavlickova T, Revol-Cavalier J, Vigor C, Lee JCY, et al. Essays Biochem. 2020 Sep 23;64(3):463–84. PubMed Europe PMC Scholia
- Does leukotriene F4 play a major role in the infection mechanism of Candida sp.? Melo CFOR, Bachur LF, Delafiori J, Dabaja MZ, de Oliveira DN, Guerreiro TM, et al. Microb Pathog. 2020 Dec;149:104394. PubMed Europe PMC Scholia
- The enzymology of human eicosanoid pathways: the lipoxygenase branches. Biringer RG. Mol Biol Rep. 2020 Sep;47(9):7189–207. PubMed Europe PMC Scholia
- Effect of Prostanoids on Human Platelet Function: An Overview. Braune S, Küpper JH, Jung F. Int J Mol Sci. 2020 Nov 27;21(23):9020. PubMed Europe PMC Scholia
- Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength. Palla AR, Ravichandran M, Wang YX, Alexandrova L, Yang AV, Kraft P, et al. Science. 2021 Jan 29;371(6528):eabc8059. PubMed Europe PMC Scholia
- Fibroblast Senescence in Idiopathic Pulmonary Fibrosis. Lin Y, Xu Z. Front Cell Dev Biol. 2020 Nov 25;8:593283. PubMed Europe PMC Scholia
- The Biosynthesis of Enzymatically Oxidized Lipids. Hajeyah AA, Griffiths WJ, Wang Y, Finch AJ, O’Donnell VB. Front Endocrinol (Lausanne). 2020 Nov 19;11:591819. PubMed Europe PMC Scholia
- COX2 regulates senescence secretome composition and senescence surveillance through PGE2. Gonçalves S, Yin K, Ito Y, Chan A, Olan I, Gough S, et al. Cell Rep. 2021 Mar 16;34(11):108860. PubMed Europe PMC Scholia
- Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis. Wiley CD, Sharma R, Davis SS, Lopez-Dominguez JA, Mitchell KP, Wiley S, et al. Cell Metab. 2021 Jun 1;33(6):1124-1136.e5. PubMed Europe PMC Scholia
- A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action. Biringer RG. J Cell Commun Signal. 2022 Mar;16(1):5–46. PubMed Europe PMC Scholia
- Prostaglandin I2 and T Regulatory Cell Function: Broader Impacts. Norlander AE, Peebles RS. DNA Cell Biol. 2021 Oct;40(10):1231–4. PubMed Europe PMC Scholia
- Cyclopentenone Prostaglandins: Biologically Active Lipid Mediators Targeting Inflammation. Lee BR, Paing MH, Sharma-Walia N. Front Physiol. 2021 Jul 15;12:640374. PubMed Europe PMC Scholia
- Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021. Djuricic I, Calder PC. Nutrients. 2021 Jul 15;13(7):2421. PubMed Europe PMC Scholia
- The Functions of Cytochrome P450 ω-hydroxylases and the Associated Eicosanoids in Inflammation-Related Diseases. Ni KD, Liu JY. Front Pharmacol. 2021 Sep 14;12:716801. PubMed Europe PMC Scholia
- Prostaglandin D2 metabolites activate asthmatic patient-derived type 2 innate lymphoid cells and eosinophils via the DP2 receptor. Carstensen S, Gress C, Erpenbeck VJ, Kazani SD, Hohlfeld JM, Sandham DA, et al. Respir Res. 2021 Oct 7;22(1):262. PubMed Europe PMC Scholia
- New understandings of the pathway of long-chain polyunsaturated fatty acid biosynthesis. Brenna JT, Kothapalli KSD. Curr Opin Clin Nutr Metab Care. 2022 Mar 1;25(2):60–6. PubMed Europe PMC Scholia
- On the biosynthesis of specialized pro-resolving mediators in human neutrophils and the influence of cell integrity. Mainka M, George S, Angioni C, Ebert R, Goebel T, Kampschulte N, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Mar;1867(3):159093. PubMed Europe PMC Scholia
- Role of arachidonic acid lipoxygenase pathway in Asthma. Luo Y, Jin M, Lou L, Yang S, Li C, Li X, et al. Prostaglandins Other Lipid Mediat. 2022 Feb;158:106609. PubMed Europe PMC Scholia
- Key Enzymes in Fatty Acid Synthesis Pathway for Bioactive Lipids Biosynthesis. Zhuang XY, Zhang YH, Xiao AF, Zhang AH, Fang BS. Front Nutr. 2022 Feb 23;9:851402. PubMed Europe PMC Scholia
- Cell cycle regulation: p53-p21-RB signaling. Engeland K. Cell Death Differ. 2022 May;29(5):946–60. PubMed Europe PMC Scholia
- Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions. Dyall SC, Balas L, Bazan NG, Brenna JT, Chiang N, da Costa Souza F, et al. Prog Lipid Res. 2022 Apr;86:101165. PubMed Europe PMC Scholia
- Prostanoid Metabolites as Biomarkers in Human Disease. Idborg H, Pawelzik SC. Metabolites. 2022 Aug 4;12(8):721. PubMed Europe PMC Scholia
- Dihomo-γ-Linolenic Acid (20:3n-6)-Metabolism, Derivatives, and Potential Significance in Chronic Inflammation. Mustonen AM, Nieminen P. Int J Mol Sci. 2023 Jan 20;24(3):2116. PubMed Europe PMC Scholia
- Formation of lipoxins and resolvins in human leukocytes. Kahnt AS, Schebb NH, Steinhilber D. Prostaglandins Other Lipid Mediat. 2023 Jun;166:106726. PubMed Europe PMC Scholia
- Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic Pathways. Chi J, Cheng J, Wang S, Li C, Chen M. Int J Mol Sci. 2023 Aug 27;24(17):13282. PubMed Europe PMC Scholia