Androgen biosynthesis (WP5393)
Homo sapiens
Androgen metabolism from L Schiffer
For a description of pathway objects, see the WikiPathways Legend.
Authors
Matthew Conroy , Egon Willighagen , and Kristina HanspersActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
steroid biosynthetic pathway lipid metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| 5beta-androstan-16alpha,17beta-diol-3one | Metabolite | lipidmaps:LMST02020139 | |
| 11-keto-testosterone | Metabolite | lipidmaps:LMST02020120 | |
| 5-Androstenediol | Metabolite | lipidmaps:LMST02020005 | |
| 11-Keto-5beta-dihydrotestosterone | Metabolite | lipidmaps:LMST02020127 | |
| Adrenosterone | Metabolite | lipidmaps:LMST02020126 | |
| 5alpha-androstan-16alpha,17beta-diol-3one | Metabolite | lipidmaps:LMST02020138 | |
| 16alpha-hydroxyprogesterone | Metabolite | lipidmaps:LMST02030182 | |
| 5beta-Androstane-3,11,17-trione | Metabolite | lipidmaps:LMST02020131 | |
| 17alpha-hydroxyprogesterone | Metabolite | lipidmaps:LMST02030161 | |
| 11beta-hydroxyandrosterone | Metabolite | lipidmaps:LMST02020086 | |
| 5alpha-androstan-11beta,17beta-diol-3one | Metabolite | lipidmaps:LMST02020136 | |
| 17alpha-hydroxypregnenolone | Metabolite | lipidmaps:LMST02030089 | |
| Testosterone | Metabolite | lipidmaps:LMST02020002 | |
| 5beta-androstan-16alpha-ol-3,17-dione | Metabolite | lipidmaps:LMST02020140 | |
| 6beta-hydroxytestosterone | Metabolite | lipidmaps:LMST02020054 | |
| 11-Ketodihydrotestosterone | Metabolite | lipidmaps:LMST02020122 | |
| Etiocholanolone | Metabolite | lipidmaps:LMST02020059 | |
| 5alpha-androstan-16alpha-ol-3,17-dione | Metabolite | lipidmaps:LMST02020141 | |
| 5alpha-Pregnan-17alpha-ol-3,20-dione | Metabolite | lipidmaps:LMST02030304 | |
| 5beta-androstane-3alpha,17beta-diol | Metabolite | lipidmaps:LMST02020077 | |
| 5beta-Dihydrotestosterone | Metabolite | lipidmaps:LMST02020069 | |
| 5alpha-androstane-3alpha,17beta-diol | Metabolite | lipidmaps:LMST02020052 | |
| Allopregnanolone | Metabolite | lipidmaps:LMST02030130 | |
| Androstenedione | Metabolite | lipidmaps:LMST02020007 | |
| Progesterone | Metabolite | lipidmaps:LMST02030159 | |
| 5alpha-dihydroprogesterone | Metabolite | lipidmaps:LMST02030170 | |
| Pregnenolone | Metabolite | lipidmaps:LMST02030088 | |
| Androsterone | Metabolite | lipidmaps:LMST02020001 | |
| 11beta-hydroxyandrostan-3,17-dione | Metabolite | lipidmaps:LMST02020121 | |
| 5alpha-dihydrotesosterone | Metabolite | lipidmaps:LMST02020042 | |
| 17alpha-hydroxy-alloprogesterone | Metabolite | lipidmaps:LMST02030305 | |
| 5alpha-Androstan-3alpha,16alpha,17beta-triol | Metabolite | lipidmaps:LMST02020134 | |
| 11beta-Hydroxyandrostenedione | Metabolite | lipidmaps:LMST02020066 | |
| Dehydroepiandrosterone | Metabolite | lipidmaps:LMST02020021 | |
| 5alpha-androstanedione | Metabolite | lipidmaps:LMST02020085 | |
| 5alpha-Androstane-3,11,17-trione | Metabolite | lipidmaps:LMST02020130 | |
| 5beta-androstanedione | Metabolite | lipidmaps:LMST02020058 | |
| 11beta-hydroxytestosterone | Metabolite | lipidmaps:LMST02020124 | |
| 16alpha-Hydroxytestosterone | Metabolite | lipidmaps:LMST02020125 | |
| DHEAS | Metabolite | lipidmaps:LMST05020010 | |
| 16alpha-Hydroxydehydroepiandrosterone | Metabolite | lipidmaps:LMST02020064 | |
| Estriol | Metabolite | lipidmaps:LMST02010003 | |
| 16alpha-hydroxyestrone | Metabolite | lipidmaps:LMST02010041 | |
| 3beta,16alpha-Dihydroxy-androstenone sulfate | Metabolite | lipidmaps:LMST05020022 | |
| 5beta-Androstan-3alpha,16alpha,17beta-triol | Metabolite | lipidmaps:LMST02020135 | |
| 16alpha-Hydroxyetiocholanolone | Metabolite | lipidmaps:LMST02020132 | |
| 16alpha-hydroxyandrosterone | Metabolite | lipidmaps:LMST02020133 | |
| 5beta-Androstan-3alpha,17beta-diol-11-one | Metabolite | lipidmaps:LMST02020128 | |
| 11-Ketoetiocholanolone | Metabolite | lipidmaps:LMST02020123 | |
| 5alpha-Androstan-3alpha,17beta-diol-11-one | Metabolite | lipidmaps:LMST02020129 | |
| 11-Ketoandrosterone | Metabolite | lipidmaps:LMST02020087 | |
| HSD17B4 | GeneProduct | uniprot:P51659 | |
| HSD17B2 | GeneProduct | uniprot:P37059 | |
| SRD5A2 | GeneProduct | uniprot:P31213 | |
| HSD3B2 | GeneProduct | uniprot:P26439 | |
| STS | GeneProduct | uniprot:P08842 | |
| SRD5A1 | GeneProduct | uniprot:P18405 | |
| CYP11B1 | GeneProduct | uniprot:P15538 | |
| AKR1D1 | GeneProduct | uniprot:P51857 | |
| POR | GeneProduct | uniprot:P16435 | |
| HSD17B3 | GeneProduct | uniprot:P37058 | |
| CYP3A4 | GeneProduct | uniprot:P08684 | |
| HSD3B1 | GeneProduct | uniprot:P14060 | |
| CYP3A7 | GeneProduct | uniprot:P24462 | |
| HSD11B2 | GeneProduct | uniprot:P80365 | |
| HSD11B1 | GeneProduct | uniprot:P28845 | |
| SULT2A1 | GeneProduct | uniprot:Q06520 | |
| AKR1C4 | GeneProduct | uniprot:P17516 | |
| AKR1C3 | GeneProduct | uniprot:P42330 | |
| AKR1C1 | GeneProduct | uniprot:Q04828 | |
| AKR1C2 | GeneProduct | uniprot:P52895 | |
| CYP17A1 | GeneProduct | uniprot:P05093 | |
| HSD17B1 | GeneProduct | uniprot:P14061 |
References
- 11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant prostate cancer? Storbeck KH, Bloem LM, Africander D, Schloms L, Swart P, Swart AC. Mol Cell Endocrinol. 2013 Sep 5;377(1–2):135–46. PubMed Europe PMC Scholia
- The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1. Barnard L, Nikolaou N, Louw C, Schiffer L, Gibson H, Gilligan LC, et al. J Steroid Biochem Mol Biol. 2020 Sep;202:105724. PubMed Europe PMC Scholia