Growth factors and hormones in beta cell proliferation (WP5385)

Homo sapiens

Growh factors and hormones in Beta-cell proliferation

Authors

Leyla Önder , Cereno98 , Petra Tesic , Egon Willighagen , Kristina Hanspers , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

Ras family mediated signaling pathway phosphatidylinositol 3-kinase-Akt signaling pathway calcium/calcium-mediated signaling pathway insulin signaling pathway transforming growth factor-beta superfamily mediated signaling pathway

Cell Type Ontology

type B pancreatic cell

Participants

Label Type Compact URI Comment
T3 Metabolite chebi:18258
T4 Metabolite chebi:18332
Ca2+ Metabolite chebi:29108
Pdx1 GeneProduct uniprot:P52945
PI3K GeneProduct interpro:IPR000403 The InterPro indentifier for the family was selected, as no specifc protein of the family was stated in the publication.
ERK 1 GeneProduct uniprot:P27361
PDGFR-a GeneProduct uniprot:A0A387LBM6 In contrast to the pathway figure, the specific receptor was included as DataNode.
TGFB1 GeneProduct uniprot:P01137
AKT1 GeneProduct uniprot:P31749
TGFB1R GeneProduct uniprot:P36897
TRs GeneProduct interpro:IPR001728
K-Ras GeneProduct uniprot:P01116
P16ink4a GeneProduct uniprot:R9S252
NFAT GeneProduct interpro:IPR008366 The InterPro indentifier for the family was selected, as no specifc protein of the family was stated in the publication.
Insulin GeneProduct uniprot:P01308
PDGFa GeneProduct uniprot:P04085
EZH2 GeneProduct uniprot:Q75MQ0
B-Raf GeneProduct uniprot:P15056
IGF-1R GeneProduct uniprot:P08069 In contrast to the pathway figure, the specific receptor was included as DataNode.
Smad7 GeneProduct uniprot:O15105
PLGF GeneProduct uniprot:P49763
Rab43 GeneProduct uniprot:Q86YS6
CRTC2 GeneProduct uniprot:Q53ET0
VEGFR-1 GeneProduct uniprot:P17948 The pathway figure namesthe receptor for PLGF as PLGF. The UniProt websites states that the receptor for PLGF is VEGFR-1. But the original publication (PMID: 25924650) states VEGFR-1 as receptor.
FOXO1 GeneProduct uniprot:Q12778
IR GeneProduct uniprot:P06213 In contrast to the pathway figure, the specific receptor was included as DataNode.
IGF-1 GeneProduct uniprot:P05019
Pref-1 GeneProduct uniprot:P80370 Synonyms: Dlk-1
Rasf1a GeneProduct uniprot:Q9NS23
cMyc GeneProduct uniprot:P01106
CDK2 GeneProduct uniprot:P24941
CDK4 GeneProduct uniprot:P11802
FOXM1 GeneProduct uniprot:Q08050
ERK 2 GeneProduct uniprot:P28482
AKT2 GeneProduct uniprot:P31751
AKT3 GeneProduct uniprot:Q9Y243

References

  1. Compromised beta-cell development and beta-cell dysfunction in weanling offspring from dams maintained on a high-fat diet during gestation. Cerf ME, Williams K, Chapman CS, Louw J. Pancreas. 2007 Apr;34(3):347–53. PubMed Europe PMC Scholia
  2. EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic β-cells. Wang H, Gambosova K, Cooper ZA, Holloway MP, Kassai A, Izquierdo D, et al. BMC Mol Biol. 2010 Aug 31;11:66. PubMed Europe PMC Scholia
  3. Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, et al. Cell Metab. 2010 Dec 1;12(6):619–32. PubMed Europe PMC Scholia
  4. Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet β-cells. Demozay D, Tsunekawa S, Briaud I, Shah R, Rhodes CJ. Diabetes. 2011 Nov;60(11):2892–902. PubMed Europe PMC Scholia
  5. PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Chen H, Gu X, Liu Y, Wang J, Wirt SE, Bottino R, et al. Nature. 2011 Oct 12;478(7369):349–55. PubMed Europe PMC Scholia
  6. Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT. Goodyer WR, Gu X, Liu Y, Bottino R, Crabtree GR, Kim SK. Dev Cell. 2012 Jul 17;23(1):21–34. PubMed Europe PMC Scholia
  7. Triiodothyronine induces proliferation of pancreatic β-cells through the MAPK/ERK pathway. Kim TK, Lee JS, Jung HS, Ha TK, Kim SM, Han N, et al. Exp Clin Endocrinol Diabetes. 2014 Apr;122(4):240–5. PubMed Europe PMC Scholia
  8. M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7. Xiao X, Gaffar I, Guo P, Wiersch J, Fischbach S, Peirish L, et al. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1211-20. PubMed Europe PMC Scholia
  9. Menin determines K-RAS proliferative outputs in endocrine cells. Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, et al. J Clin Invest. 2014 Sep;124(9):4093–101. PubMed Europe PMC Scholia
  10. Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway. Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, et al. Elife. 2014 Sep 16;3:e02809. PubMed Europe PMC Scholia
  11. Exendin-4 Promotes Beta Cell Proliferation via PI3k/Akt Signalling Pathway. Wang C, Chen X, Ding X, He Y, Gu C, Zhou L. Cell Physiol Biochem. 2015;35(6):2223–32. PubMed Europe PMC Scholia
  12. Pre-Eclampsia-Associated Reduction in Placental Growth Factor Impaired Beta Cell Proliferation Through PI3k Signalling. Li J, Ying H, Cai G, Guo Q, Chen L. Cell Physiol Biochem. 2015;36(1):34–43. PubMed Europe PMC Scholia
  13. Effects of phycocyanin on INS-1 pancreatic β-cell mediated by PI3K/Akt/FoxO1 signaling pathway. Gao Y, Liao G, Xiang C, Yang X, Cheng X, Ou Y. Int J Biol Macromol. 2016 Feb;83:185–94. PubMed Europe PMC Scholia
  14. Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells. Rhee M, Lee SH, Kim JW, Ham DS, Park HS, Yang HK, et al. Sci Rep. 2016 Apr 5;6:23960. PubMed Europe PMC Scholia
  15. Cellular signaling pathways regulating β-cell proliferation as a promising therapeutic target in the treatment of diabetes. Jiang WJ, Peng YC, Yang KM. Exp Ther Med. 2018 Oct;16(4):3275–85. PubMed Europe PMC Scholia
  16. The Role of Calcium-Calcineurin-NFAT Signaling Pathway in Health and Autoimmune Diseases. Park YJ, Yoo SA, Kim M, Kim WU. Front Immunol. 2020 Mar 10;11:195. PubMed Europe PMC Scholia