Ergosterol biosynthesis (WP5354)

Saccharomyces cerevisiae

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Ergosterol biosynthesis in yeast

Authors

Conroy lipids , Aishwarya Iyer , Egon Willighagen , Alex Pico , and Kristina Hanspers

Activity

last edited

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Cited In

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Organisms

Saccharomyces cerevisiae

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology

classic metabolic pathway cholesterol biosynthetic pathway lipid signaling pathway cholesterol metabolic pathway

Participants

Label Type Compact URI Comment
Zymosterone Metabolite lipidmaps:LMST01010168
Acetyl-CoA Metabolite lipidmaps:LMFA07050281
4α-formyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol Metabolite lipidmaps:LMST01010229
Eburicol Metabolite lipidmaps:LMST01031311
32-Oxolanosterol Metabolite lipidmaps:LMST01010222
Ergosterol Metabolite lipidmaps:LMST01030093
4α-formyl-5α-cholesta-8,24-dien-3β-ol Metabolite lipidmaps:LMST01010226
4α-hydroxymethyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol Metabolite lipidmaps:LMST01010232
3-keto-4alpha-methyl-zymosterol Metabolite lipidmaps:LMST01010237
4α-hydroxymethyl-5α-cholesta-8,24-dien-3β-ol Metabolite lipidmaps:LMST01010234
ergosta-5,7,22,24(28)-tetraen-3beta-ol Metabolite lipidmaps:LMST01031015
IPP Metabolite lipidmaps:LMPR01010008
4α-carboxyzymosterol Metabolite lipidmaps:LMST01010522
Acetoacetyl-CoA Metabolite lipidmaps:LMFA07050030
HMG-CoA Metabolite lipidmaps:LMFA07050116
Mevalonic acid Metabolite lipidmaps:LMFA01050352
Mevalonate-5-P Metabolite lipidmaps:LMFA01050415
Mevalonate-5-PP Metabolite lipidmaps:LMFA01050416
Isopentenyl-PP Metabolite lipidmaps:LMPR01010008
Dimethylallyl-PP Metabolite lipidmaps:LMPR01010001
Geranyl-PP Metabolite lipidmaps:LMPR0102010001
Farnesyl-PP Metabolite lipidmaps:LMPR0103010002
Squalene Metabolite lipidmaps:LMPR0106010002
Squalene-2,3-epoxide Metabolite lipidmaps:LMPR0106010010
Lanosterol Metabolite lipidmaps:LMST01010017
32-hydroxylanosterol Metabolite lipidmaps:LMST01010124
4,4-dimethylcholesta-8,11,24-trienol Metabolite lipidmaps:LMST01010149
4,4-dimethylzymosterol Metabolite lipidmaps:LMST01010176
Zymosterol Metabolite lipidmaps:LMST01010066
Fecosterol Metabolite lipidmaps:LMST01030095 aka 24-dehydrolathosterol
Episterol Metabolite lipidmaps:LMST01030115
5-dehydroepisterol Metabolite lipidmaps:LMST01030135
PreSqualene-PP Metabolite lipidmaps:LMPR0106010003 Annotated while assuming this compound is actually presqualene-diphosphate
4-methyl-4-carboxyzymosterone Metabolite lipidmaps:LMST01010388 C12CC[C@@]3([H])C(C)(COOH)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H
4alpha-methyl zymosterol Metabolite lipidmaps:LMST01010202 C12CC[C@@]3([H])C(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H
ERG10 GeneProduct uniprot:P41338
HMG1 GeneProduct uniprot:P12683
ERG5 GeneProduct uniprot:P54781
ERG6 GeneProduct uniprot:P25087
ERG3 GeneProduct uniprot:P32353
ERG4 GeneProduct uniprot:P25340
ERG2 GeneProduct uniprot:P32352
ERG24 GeneProduct uniprot:P32462
ERG13 GeneProduct uniprot:P54839
ERG12 GeneProduct uniprot:P07277
ERG8 GeneProduct uniprot:P24521
ERG19 GeneProduct uniprot:P32377
ERG1 GeneProduct uniprot:P32476
IDI1 GeneProduct uniprot:P15496
ERG9 GeneProduct uniprot:P29704
Ggps1 GeneProduct ncbigene:14593
ERG7 GeneProduct uniprot:P38604
ERG26 GeneProduct uniprot:P53199
HMG2 GeneProduct uniprot:P12684
ERG25 Protein uniprot:P53045
ERG11 Protein uniprot:P10614
ERG27 Protein uniprot:Q12452

References

  1. Steroidal triterpenes of cholesterol synthesis. Ačimovič J, Rozman D. Molecules. 2013 Apr 4;18(4):4002–17. PubMed Europe PMC Scholia
  2. A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. Mazein A, Watterson S, Hsieh WY, Griffiths WJ, Ghazal P. Biochem Pharmacol. 2013 Jul 1;86(1):56–66. PubMed Europe PMC Scholia
  3. Overexpression or Deletion of Ergosterol Biosynthesis Genes Alters Doubling Time, Response to Stress Agents, and Drug Susceptibility in Saccharomyces cerevisiae. Bhattacharya S, Esquivel BD, White TC. mBio. 2018 Jul 24;9(4):e01291-18. PubMed Europe PMC Scholia