Ergosterol biosynthesis (WP5354)
Saccharomyces cerevisiae
Ergosterol biosynthesis in yeast
Authors
Conroy lipids , Aishwarya Iyer , Egon Willighagen , and Alex PicoActivity
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Cited In
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Organisms
Saccharomyces cerevisiaeCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology
lipid signaling pathway classic metabolic pathway cholesterol biosynthetic pathway cholesterol metabolic pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
Zymosterone | Metabolite | lipidmaps:LMST01010168 | |
Acetyl-CoA | Metabolite | lipidmaps:LMFA07050281 | |
4α-formyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol | Metabolite | lipidmaps:LMST01010229 | |
Eburicol | Metabolite | lipidmaps:LMST01031311 | |
32-Oxolanosterol | Metabolite | lipidmaps:LMST01010222 | |
Ergosterol | Metabolite | lipidmaps:LMST01030093 | |
4α-formyl-5α-cholesta-8,24-dien-3β-ol | Metabolite | lipidmaps:LMST01010226 | |
4α-hydroxymethyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol | Metabolite | lipidmaps:LMST01010232 | |
3-keto-4alpha-methyl-zymosterol | Metabolite | lipidmaps:LMST01010237 | |
4α-hydroxymethyl-5α-cholesta-8,24-dien-3β-ol | Metabolite | lipidmaps:LMST01010234 | |
ergosta-5,7,22,24(28)-tetraen-3beta-ol | Metabolite | lipidmaps:LMST01031015 | |
IPP | Metabolite | lipidmaps:LMPR01010008 | |
4α-carboxyzymosterol | Metabolite | lipidmaps:LMST01010522 | |
Acetoacetyl-CoA | Metabolite | lipidmaps:LMFA07050030 | |
HMG-CoA | Metabolite | lipidmaps:LMFA07050116 | |
Mevalonic acid | Metabolite | lipidmaps:LMFA01050352 | |
Mevalonate-5-P | Metabolite | lipidmaps:LMFA01050415 | |
Mevalonate-5-PP | Metabolite | lipidmaps:LMFA01050416 | |
Isopentenyl-PP | Metabolite | lipidmaps:LMPR01010008 | |
Dimethylallyl-PP | Metabolite | lipidmaps:LMPR01010001 | |
Geranyl-PP | Metabolite | lipidmaps:LMPR0102010001 | |
Farnesyl-PP | Metabolite | lipidmaps:LMPR0103010002 | |
Squalene | Metabolite | lipidmaps:LMPR0106010002 | |
Squalene-2,3-epoxide | Metabolite | lipidmaps:LMPR0106010010 | |
Lanosterol | Metabolite | lipidmaps:LMST01010017 | |
32-hydroxylanosterol | Metabolite | lipidmaps:LMST01010124 | |
4,4-dimethylcholesta-8,11,24-trienol | Metabolite | lipidmaps:LMST01010149 | |
4,4-dimethylzymosterol | Metabolite | lipidmaps:LMST01010176 | |
Zymosterol | Metabolite | lipidmaps:LMST01010066 | |
Fecosterol | Metabolite | lipidmaps:LMST01030095 | aka 24-dehydrolathosterol |
Episterol | Metabolite | lipidmaps:LMST01030115 | |
5-dehydroepisterol | Metabolite | lipidmaps:LMST01030135 | |
PreSqualene-PP | Metabolite | lipidmaps:LMPR0106010003 | Annotated while assuming this compound is actually presqualene-diphosphate |
IPP | Metabolite | lipidmaps:LMPR01010008 | |
Acetyl-CoA | Metabolite | lipidmaps:LMFA07050281 | |
4-methyl-4-carboxyzymosterone | Metabolite | lipidmaps:LMST01010388 | C12CC[C@@]3([H])C(C)(COOH)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H |
4alpha-methyl zymosterol | Metabolite | lipidmaps:LMST01010202 | C12CC[C@@]3([H])C(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H |
ERG10 | GeneProduct | uniprot:P41338 | |
HMG1 | GeneProduct | uniprot:P12683 | |
ERG5 | GeneProduct | uniprot:P54781 | |
ERG6 | GeneProduct | uniprot:P25087 | |
ERG3 | GeneProduct | uniprot:P32353 | |
ERG4 | GeneProduct | uniprot:P25340 | |
ERG2 | GeneProduct | uniprot:P32352 | |
ERG6 | GeneProduct | uniprot:P25087 | |
ERG24 | GeneProduct | uniprot:P32462 | |
ERG13 | GeneProduct | uniprot:P54839 | |
ERG12 | GeneProduct | uniprot:P07277 | |
ERG8 | GeneProduct | uniprot:P24521 | |
ERG19 | GeneProduct | uniprot:P32377 | |
ERG1 | GeneProduct | uniprot:P32476 | |
IDI1 | GeneProduct | uniprot:P15496 | |
ERG9 | GeneProduct | uniprot:P29704 | |
Ggps1 | GeneProduct | ncbigene:14593 | |
ERG7 | GeneProduct | uniprot:P38604 | |
ERG26 | GeneProduct | uniprot:P53199 | |
HMG2 | GeneProduct | uniprot:P12684 | |
ERG26 | GeneProduct | uniprot:P53199 | |
ERG25 | Protein | uniprot:P53045 | |
ERG11 | Protein | uniprot:P10614 | |
ERG27 | Protein | uniprot:Q12452 | |
ERG25 | Protein | uniprot:P53045 | |
ERG11 | Protein | uniprot:P10614 | |
ERG27 | Protein | uniprot:Q12452 |
References
- Steroidal triterpenes of cholesterol synthesis. Ačimovič J, Rozman D. Molecules. 2013 Apr 4;18(4):4002–17. PubMed Europe PMC Scholia
- A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. Mazein A, Watterson S, Hsieh WY, Griffiths WJ, Ghazal P. Biochem Pharmacol. 2013 Jul 1;86(1):56–66. PubMed Europe PMC Scholia
- Overexpression or Deletion of Ergosterol Biosynthesis Genes Alters Doubling Time, Response to Stress Agents, and Drug Susceptibility in Saccharomyces cerevisiae. Bhattacharya S, Esquivel BD, White TC. mBio. 2018 Jul 24;9(4):e01291-18. PubMed Europe PMC Scholia