Ergosterol biosynthesis (WP5354)
Saccharomyces cerevisiae
This pathway is inspired by the LipidMaps, Sterol lipids expended pathway display (see LipidMaps) and extended with Scheme 1 from Acimovic et al. 2013. Literature suggests that cholesterol synthesis preferentially starts with the Bloch pathway, however there is a shift to the Kandutsch-Russell part via lathosterol from Bae et al, 1997. Dashed lines indicate that multiple steps are involved to create the final product.
For a description of pathway objects, see the WikiPathways Legend.
Authors
Matthew Conroy , Aishwarya Iyer , Egon Willighagen , Alex Pico , Kristina Hanspers , and Daniela DiglesActivity
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Organisms
Saccharomyces cerevisiaeCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology
cholesterol metabolic pathway lipid signaling pathway classic metabolic pathway cholesterol biosynthetic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Zymosterone | Metabolite | lipidmaps:LMST01010168 | |
| Acetyl-CoA | Metabolite | lipidmaps:LMFA07050281 | |
| 4α-formyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol | Metabolite | lipidmaps:LMST01010229 | |
| Eburicol | Metabolite | lipidmaps:LMST01031311 | |
| 32-Oxolanosterol | Metabolite | lipidmaps:LMST01010222 | |
| Ergosterol | Metabolite | lipidmaps:LMST01030093 | |
| 4α-formyl-5α-cholesta-8,24-dien-3β-ol | Metabolite | lipidmaps:LMST01010226 | |
| 4α-hydroxymethyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol | Metabolite | lipidmaps:LMST01010232 | |
| 3-keto-4alpha-methyl-zymosterol | Metabolite | lipidmaps:LMST01010237 | |
| 4α-hydroxymethyl-5α-cholesta-8,24-dien-3β-ol | Metabolite | lipidmaps:LMST01010234 | |
| ergosta-5,7,22,24(28)-tetraen-3beta-ol | Metabolite | lipidmaps:LMST01031015 | |
| IPP | Metabolite | lipidmaps:LMPR01010008 | |
| 4α-carboxyzymosterol | Metabolite | lipidmaps:LMST01010522 | |
| Acetoacetyl-CoA | Metabolite | lipidmaps:LMFA07050030 | |
| HMG-CoA | Metabolite | lipidmaps:LMFA07050116 | |
| Mevalonic acid | Metabolite | lipidmaps:LMFA01050352 | |
| Mevalonate-5-P | Metabolite | lipidmaps:LMFA01050415 | |
| Mevalonate-5-PP | Metabolite | lipidmaps:LMFA01050416 | |
| Isopentenyl-PP | Metabolite | lipidmaps:LMPR01010008 | |
| Dimethylallyl-PP | Metabolite | lipidmaps:LMPR01010001 | |
| Geranyl-PP | Metabolite | lipidmaps:LMPR0102010001 | |
| Farnesyl-PP | Metabolite | lipidmaps:LMPR0103010002 | |
| Squalene | Metabolite | lipidmaps:LMPR0106010002 | |
| Squalene-2,3-epoxide | Metabolite | lipidmaps:LMPR0106010010 | |
| Lanosterol | Metabolite | lipidmaps:LMST01010017 | |
| 32-hydroxylanosterol | Metabolite | lipidmaps:LMST01010124 | |
| 4,4-dimethylcholesta-8,11,24-trienol | Metabolite | lipidmaps:LMST01010149 | |
| 4,4-dimethylzymosterol | Metabolite | lipidmaps:LMST01010176 | |
| Zymosterol | Metabolite | lipidmaps:LMST01010066 | |
| Fecosterol | Metabolite | lipidmaps:LMST01030095 | aka 24-dehydrolathosterol |
| Episterol | Metabolite | lipidmaps:LMST01030115 | |
| 5-dehydroepisterol | Metabolite | lipidmaps:LMST01030135 | |
| PreSqualene-PP | Metabolite | lipidmaps:LMPR0106010003 | Annotated while assuming this compound is actually presqualene-diphosphate |
| 4-methyl-4-carboxyzymosterone | Metabolite | lipidmaps:LMST01010388 | C12CC[C@@]3([H])C(C)(COOH)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H |
| 4alpha-methyl zymosterol | Metabolite | lipidmaps:LMST01010202 | C12CC[C@@]3([H])C(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H |
| ERG10 | GeneProduct | uniprot:P41338 | |
| HMG1 | GeneProduct | uniprot:P12683 | |
| ERG5 | GeneProduct | uniprot:P54781 | |
| ERG6 | GeneProduct | uniprot:P25087 | |
| ERG3 | GeneProduct | uniprot:P32353 | |
| ERG4 | GeneProduct | uniprot:P25340 | |
| ERG2 | GeneProduct | uniprot:P32352 | |
| ERG24 | GeneProduct | uniprot:P32462 | |
| ERG13 | GeneProduct | uniprot:P54839 | |
| ERG12 | GeneProduct | uniprot:P07277 | |
| ERG8 | GeneProduct | uniprot:P24521 | |
| ERG19 | GeneProduct | uniprot:P32377 | |
| ERG1 | GeneProduct | uniprot:P32476 | |
| IDI1 | GeneProduct | uniprot:P15496 | |
| ERG9 | GeneProduct | uniprot:P29704 | |
| Ggps1 | GeneProduct | ncbigene:14593 | |
| ERG7 | GeneProduct | uniprot:P38604 | |
| ERG26 | GeneProduct | uniprot:P53199 | |
| HMG2 | GeneProduct | uniprot:P12684 | |
| ERG25 | Protein | uniprot:P53045 | |
| ERG11 | Protein | uniprot:P10614 | |
| ERG27 | Protein | uniprot:Q12452 |
References
- Steroidal triterpenes of cholesterol synthesis. Ačimovič J, Rozman D. Molecules. 2013 Apr 4;18(4):4002–17. PubMed Europe PMC Scholia
- A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. Mazein A, Watterson S, Hsieh WY, Griffiths WJ, Ghazal P. Biochem Pharmacol. 2013 Jul 1;86(1):56–66. PubMed Europe PMC Scholia
- Overexpression or Deletion of Ergosterol Biosynthesis Genes Alters Doubling Time, Response to Stress Agents, and Drug Susceptibility in Saccharomyces cerevisiae. Bhattacharya S, Esquivel BD, White TC. mBio. 2018 Jul 24;9(4):e01291-18. PubMed Europe PMC Scholia