Enterocyte cholesterol metabolism (WP5333)
Homo sapiens
This pathway shows the cholesterol absorption and biosynthesis in the enterocyte.
Authors
Tom Pauly , Denise Slenter , Susan Coort , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
cholesterol metabolic pathway cholesterol transport pathway cholesterol biosynthetic pathwayCell Type Ontology
enterocyte| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Esterase | Metabolite | hmdb:HMDB0302632 | |
| Phospholipase | Metabolite | hmdb:HMDB0302979 | |
| phospholipids | Metabolite | chebi:16247 | |
| cholesterol | Metabolite | chebi:16113 | |
| cholesterol esters | Metabolite | chebi:17002 | |
| triacylglycerols | Metabolite | chebi:17855 | |
| fatty acids | Metabolite | chebi:35366 | |
| diacylglycerols | Metabolite | chebi:18035 | |
| monoacylglycerols | Metabolite | chebi:17408 | |
| DGL | Metabolite | chebi:15966 | |
| lysophospholipids | Metabolite | chebi:16961 | |
| Acetyl-CoA | Metabolite | cas:72-89-9 | |
| HMG-CoA | Metabolite | hmdb:HMDB0001375 | |
| Mevalonic acid | Metabolite | cas:150-97-0 | |
| Mevalonic acid 5-pyrophosphate | Metabolite | cas:1492-08-6 | |
| Mevalonic acid-5P | Metabolite | cas:73566-35-5 | |
| isopentenyl pyrophosphate | Metabolite | cas:358-71-4 | |
| Dimethylallyl pyrophosphate | Metabolite | cas:358-72-5 | |
| Geranyl-PP | Metabolite | cas:6699-20-3 | |
| lanosterol | Metabolite | chebi:16521 | |
| (S)-2,3-Epoxysqualene | Metabolite | chebi:15441 | |
| farnesyl pyrophosphate | Metabolite | cas:13058-04-3 | |
| Squalene | Metabolite | cas:111-02-4 | |
| zymosterol | Metabolite | chebi:18252 | |
| desmosterol | Metabolite | chebi:17737 | |
| Zymostenol | Metabolite | chebi:16608 | |
| 24,25-dihydrolanosterol | Metabolite | chebi:28113 | |
| Lathosterol | Metabolite | cas:80-99-9 | |
| 7-Dehydrocholesterol | Metabolite | cas:434-16-2 | |
| Cholesterol | Metabolite | cas:57-88-5 | |
| SLC27A4 | GeneProduct | ensembl:ENSG00000167114 | |
| MTTP | GeneProduct | ensembl:ENSG00000138823 | |
| APOA1 | GeneProduct | ensembl:ENSG00000118137 | |
| DGAT1 | GeneProduct | ensembl:ENSG00000185000 | |
| APOA4 | GeneProduct | ensembl:ENSG00000110244 | |
| MGAT1 | GeneProduct | ensembl:ENSG00000131446 | |
| APOB | GeneProduct | ensembl:ENSG00000084674 | |
| ABCA1 | GeneProduct | ensembl:ENSG00000165029 | |
| ABCG8 | GeneProduct | ncbigene:64241 | |
| ABCG5 | GeneProduct | ncbigene:64240 | |
| NPC1L1 | GeneProduct | ensembl:ENSG00000015520 | |
| CD36 | GeneProduct | ensembl:ENSG00000135218 | |
| ACAT2 | GeneProduct | ensembl:ENSG00000120437 | |
| SAR1B | GeneProduct | ensembl:ENSG00000152700 | |
| HMGCS1 | GeneProduct | ncbigene:3157 | |
| HMGCR | GeneProduct | ncbigene:3156 | |
| MVD | GeneProduct | ncbigene:4597 | |
| PMVK | GeneProduct | ncbigene:10654 | |
| MVK | GeneProduct | ncbigene:4598 | |
| IDI1 | GeneProduct | ncbigene:3422 | |
| FDPS | GeneProduct | ncbigene:2224 | |
| SQLE | GeneProduct | ncbigene:6713 | |
| FDFT1 | GeneProduct | ncbigene:2222 | |
| LSS | GeneProduct | ncbigene:4047 | |
| DHCR24 | GeneProduct | ensembl:ENSG00000116133 | |
| EBP | GeneProduct | ensembl:ENSG00000147155 | |
| DHCR7 | GeneProduct | ncbigene:1717 | |
| SC5DL | GeneProduct | ncbigene:6309 | |
| CYP51A1 | GeneProduct | ensembl:ENSG00000001630 | |
| HSD17B7 | GeneProduct | ensembl:ENSG00000132196 | |
| NSDHL | GeneProduct | ncbigene:50814 | NAD(P) dependent steroid dehydrogenase-like |
| SC4MOL | GeneProduct | ncbigene:6307 | |
| LBR | GeneProduct | ensembl:ENSG00000143815 | |
| TM7SF2 | GeneProduct | ensembl:ENSG00000149809 | |
| LDLR | GeneProduct | ensembl:ENSG00000130164 | |
| FABP2 | GeneProduct | ensembl:ENSG00000145384 | |
| Triacylglycerol lipase | Protein | uniprot:A0A087WX88 |
References
- Cholesterol esterase activity of human intestinal mucosa. Ponz de Leon M, Carubbi F, Di Donato P, Carulli N. Dig Dis Sci. 1985 Nov;30(11):1053–64. PubMed Europe PMC Scholia
- Phospholipases: structural and functional motifs for working at an interface. Roberts MF. FASEB J. 1996 Aug;10(10):1159–72. PubMed Europe PMC Scholia
- Mechanisms by Which LRP1 (Low-Density Lipoprotein Receptor-Related Protein-1) Maintains Arterial Integrity. Gonias SL. Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2548–9. PubMed Europe PMC Scholia
- The TICE Pathway: Mechanisms and Lipid-Lowering Therapies. Grefhorst A, Verkade HJ, Groen AK. Methodist Debakey Cardiovasc J. 2019;15(1):70–6. PubMed Europe PMC Scholia
- Rare dyslipidaemias, from phenotype to genotype to management: a European Atherosclerosis Society task force consensus statement. Hegele RA, Borén J, Ginsberg HN, Arca M, Averna M, Binder CJ, et al. Lancet Diabetes Endocrinol. 2020 Jan;8(1):50–67. PubMed Europe PMC Scholia
- Regulation of intestinal lipid metabolism: current concepts and relevance to disease. Ko CW, Qu J, Black DD, Tso P. Nat Rev Gastroenterol Hepatol. 2020 Mar;17(3):169–83. PubMed Europe PMC Scholia