Axon guidance (WP5289)
Homo sapiens
Axon guidance forms neuronal networks. Axons are guided by factors including netrins, ephrins, Slits, and semaphorins. These guidance cues interact with growth cone receptors, and downstream signal transduction pathways converge onto Rho GTPases which change in cytoskeletal organization. Those cytoskeletal changes determine which way the growth cone will turn. This pathway is derived from https://www.kegg.jp/entry/map04360.
Authors
Luiz C. M. Ladeira , Kristina Hanspers , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
signaling pathway pertinent to the brain and nervous systemCell Type Ontology
neuron| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Ca2+ | Metabolite | chebi:29108 | |
| DCC | Protein | refseq:NM_005215 | |
| LRRC4C | Protein | ensembl:ENSG00000148948 | |
| CFL1 | Protein | ensembl:ENSG00000172757 | |
| RHOA | Protein | hgnc:667 | |
| PLXNA1 | Protein | ensembl:ENSG00000114554 | |
| NRP1 | Protein | ncbigene:8829 | |
| L1CAM | Protein | uniprot:P32004 | |
| SEMA3A | Protein | refseq:NM_006080 | |
| FES | Protein | refseq:NM_002005 | |
| FYN | Protein | hgnc.symbol:FYN | |
| CDK5 | Protein | hgnc.symbol:CDK5 | |
| PLCG1 | Protein | hgnc:9065 | |
| DPYSL5 | Protein | uniprot:Q9BPU6 | |
| DPYSL2 | Protein | refseq:NM_001386 | |
| PLXNB2 | Protein | hgnc:9104 | |
| SEMA4F | Protein | hgnc:10734 | |
| SEMA5B | Protein | ncbigene:54437 | |
| SEMA6C | Protein | ensembl:ENSG00000143434 | |
| SEMA7A | Protein | ncbigene:8482 | |
| MET | Protein | hgnc.symbol:MET | |
| PLXNC1 | Protein | hgnc:9106 | |
| PTK2 | Protein | hgnc:9611 | |
| ITGB1 | Protein | refseq:NM_002211 | |
| RAC1 | Protein | ncbigene:5879 | |
| PAK4 | Protein | hgnc:16059 | |
| RRAS | Protein | hgnc.symbol:RRAS | |
| RND1 | Protein | hgnc:18314 | |
| ARHGEF12 | Protein | refseq:NM_015313 | |
| SRC | Protein | uniprot:P12931 | |
| RAF1 | Protein | ensembl:ENSG00000132155 | |
| MAPK1 | Protein | ensembl:ENSG00000100030 | |
| SHH | Protein | uniprot:Q15465 | |
| PTCH1 | Protein | refseq:NM_000264 | |
| SMO | Protein | hgnc:11119 | |
| BOC | Protein | ncbigene:91653 | |
| PRKCA | Protein | hgnc.symbol:PRKCA | |
| ILK | Protein | ensembl:ENSG00000166333 | |
| WNT5A | Protein | hgnc.symbol:WNT5A | |
| FZD3 | Protein | hgnc.symbol:FZD3 | |
| RYK | Protein | ensembl:ENSG00000163785 | |
| TRPC1 | Protein | hgnc.symbol:TRPC1 | |
| CAMK2A | Protein | hgnc:1460 | |
| WNT4 | Protein | ensembl:ENSG00000162552 | |
| UNC5D | Protein | uniprot:Q6UXZ4 | |
| PIK3CA | Protein | hgnc:8975 | |
| PDPK1 | Protein | ensembl:ENSG00000140992 | |
| PRKCZ | Protein | ncbigene:5590 | |
| PARD3 | Protein | hgnc.symbol:PARD3 | |
| PARD6A | Protein | ensembl:ENSG00000102981 | |
| PPP3CA | Protein | hgnc:9314 | |
| NTN1 | Protein | hgnc:8029 | |
| BMPR2 | Protein | ncbigene:659 | |
| BMPR1B | Protein | ncbigene:658 | |
| BMP7 | Protein | hgnc:1074 | |
| GDF7 | Protein | hgnc.symbol:GDF7 | |
| LIMK1 | Protein | hgnc:6613 | |
| NTN3 | Protein | ncbigene:4917 | |
| CDC42 | Protein | ncbigene:998 | |
| NCK2 | Protein | hgnc:7665 | |
| GSK3B | Protein | hgnc.symbol:GSK3B | |
| NTN4 | Protein | ncbigene:59277 | |
| LRRC4 | Protein | hgnc:15586 | |
| NCK1 | Protein | ensembl:ENSG00000158092 | |
| PTPN11 | Protein | hgnc:9644 | |
| NFATC2 | Protein | hgnc:7776 | |
| ROCK1 | Protein | ncbigene:6093 | |
| ABLIM3 | Protein | uniprot:O94929 | |
| NEO1 | Protein | hgnc:7754 | |
| LRIG2 | Protein | ncbigene:9860 | |
| NTNG1 | Protein | hgnc:23319 | |
| RGMA | Protein | ncbigene:56963 | |
| MYL12B | Protein | ncbigene:103910 | |
| EPHA2 | Protein | hgnc.symbol:EPHA2 | |
| EPHB1 | Protein | hgnc.symbol:EPHB1 | |
| ABL1 | Protein | ensembl:ENSG00000097007 | |
| NTNG2 | Protein | refseq:NM_032536 | |
| RASA1 | Protein | refseq:NM_002890 | |
| NGEF | Protein | uniprot:Q8N5V2 | |
| ENAH | Protein | refseq:NM_018212 | |
| HRAS | Protein | ensembl:ENSG00000174775 | |
| EFNA1 | Protein | ncbigene:1942 | |
| EFNB1 | Protein | uniprot:P98172 | |
| CXCR4 | Protein | refseq:NM_001008540 | |
| CXCL12 | Protein | uniprot:P48061 | |
| RGS3 | Protein | hgnc:9999 | |
| GNAI1 | Protein | refseq:NM_002069 | |
| ROBO2 | Protein | refseq:NM_001128929 | |
| ROBO1 | Protein | uniprot:Q9Y6N7 | |
| SLIT1 | Protein | hgnc.symbol:SLIT1 | |
| SLIT2 | Protein | ncbigene:9353 | |
| SLIT3 | Protein | hgnc.symbol:SLIT3 | |
| ROBO3 | Protein | refseq:NM_022370 | |
| SRGAP2 | Protein | refseq:NM_015326 | |
| RHOD | Protein | uniprot:O00212 |
References
- Quantitative profiling of axonal guidance proteins during the differentiation of human neurospheres. Goto-Silva L, Martins M, Murillo JR, Souza LRQ, Vitória G, Oliveira JT, et al. Biochim Biophys Acta Proteins Proteom. 2021 Aug;1869(8):140656. PubMed Europe PMC Scholia