Glucose metabolism in triple-negative breast cancer cells (WP5211)

Homo sapiens

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Glucose metabolism in triple-negative breast cancer cells. The glycolytic pathway is significantly upregulated in triple-negative breast tumors. The genes coding the key glycolytic enzymes are overexpressed in triple-negative breast tumors. TCA, tricarboxylic acid cycle; G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; F1,6P, fructose-1,6-bisphosphate; PEP, phosphoenolpyruvate; OAA, oxaloacetate; α-KG, α-ketoglutarate; GLUT, glucose transporter; HK, hexokinase; PFK, phosphofructokinase; PKM2, pyruvate kinase isozyme type 2; LDHA, lactate dehydrogenase A; MCT1, monocarboxylate transporter 1; PDK1, pyruvate dehydrogenase kinase 1; PDH, pyruvate dehydrogenase.

Authors

Andra Waagmeester , Egon Willighagen , Alex Pico , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

glycolysis pathway cancer pathway pentose phosphate pathway disease pathway citric acid cycle pathway

Disease Ontology

triple-receptor negative breast cancer breast cancer

Participants
Query Drugst.One

Label Type Compact URI Comment
Acetyl CoA Metabolite chebi:15351
Lactate Metabolite chebi:16651
NADPH Metabolite chebi:16474
phosphoenolpyruvate Metabolite chebi:18021
Fructose-6-phosphate Metabolite chebi:15946
fructose-1,6-bisphosphate Metabolite chebi:78682
Glucose Metabolite wikidata:Q37525
Pyruvate Metabolite chebi:15361
glucose-6-phosphate Metabolite wikidata:Q32778969
pyruvate Metabolite chebi:15361
PDK1 GeneProduct ensembl:ENSG00000152256
HK GeneProduct ncbigene:3098
PFKP GeneProduct ncbigene:5214
GLUT1 GeneProduct ncbigene:6513
LDHA GeneProduct ensembl:ENSG00000134333
MCT1 GeneProduct ncbigene:6566
PDH GeneProduct ncbigene:54704
PKM2 GeneProduct ncbigene:5315

References

  1. Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, et al. Cancer Cell. 2013 Aug 12;24(2):213–28. PubMed Europe PMC Scholia
  2. High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis. Avanzato D, Pupo E, Ducano N, Isella C, Bertalot G, Luise C, et al. Cancer Res. 2018 Jul 1;78(13):3432–44. PubMed Europe PMC Scholia
  3. Metabolic Reprogramming in Triple-Negative Breast Cancer. Sun X, Wang M, Wang M, Yu X, Guo J, Sun T, et al. Front Oncol. 2020 Mar 31;10:428. PubMed Europe PMC Scholia