Retinol metabolism (WP5188)
Homo sapiens
This pathway describes the metabolism of retinol. Retinol, more common known as vitamin A, is involved in various physiological processes in the human body. Vitamin A must acquired from the diet. When taken up, retinol metabolism is important to create all the different retinoid forms, such as retinoic acid and retinyl esters. All these types have their own function. There are many carries proteins and enzymes specific to retinoid metabolism involved in the processes.
Authors
Rvanrosmeulen , Andra Waagmeester , Denise Slenter , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
signaling pathway pathway retinol metabolic pathway classic metabolic pathwayCell Type Ontology
compound eye retinal cell| Label | Type | Compact URI | Comment |
|---|---|---|---|
| 11-cis-retinyl palmitate | Metabolite | chebi:16254 | |
| 9-cis-retinol | Metabolite | chebi:78272 | |
| all-trans-retinal | Metabolite | chebi:17898 | |
| 11-cis retinal | Metabolite | wikidata:Q17002962 | |
| 4-oxo RA | Metabolite | chebi:80656 | |
| 9-cis-retinal | Metabolite | chebi:78273 | |
| all-trans-retinol | Metabolite | chebi:17336 | |
| all-trans-retinoate | Metabolite | chebi:35291 | |
| beta-Carotene | Metabolite | hmdb:HMDB0000561 | |
| 18-hydroxy RA | Metabolite | hmdb:HMDB0012452 | |
| 4-hydroxy RA | Metabolite | wikidata:Q27132808 | |
| 9-cis-retinoate | Metabolite | chebi:78630 | |
| 11-cis-retinol | Metabolite | chebi:16302 | |
| all-trans-retinyl esters | Metabolite | chebi:63410 | |
| Iodopsin | Metabolite | chebi:5949 | |
| 11-cis-retinyl tetradecanoate | Metabolite | chebi:138676 | |
| Retinal dehydrogenase 1 | Protein | uniprot:P00352 | |
| LRAT | Protein | uniprot:O95237 | |
| BCDO1 | Protein | uniprot:Q9HAY6 | |
| AWAT2 | Protein | uniprot:Q6E213 | |
| RDH12 | Protein | uniprot:Q96NR8 | |
| PNPL4 | Protein | uniprot:P41247 | |
| CP1A1 | Protein | uniprot:P04798 | |
| ADH1A | Protein | uniprot:P07327 | |
| SDR16C5 | Protein | uniprot:Q8N3Y7 | |
| CP2W1 | Protein | uniprot:Q8TAV3 | |
| Aldehyde oxidase | Protein | uniprot:Q06278 | |
| DHRS4 | Protein | uniprot:Q9BTZ2 | |
| CP26A | Protein | uniprot:043174 | |
| CP2A6 | Protein | uniprot:P11509 | |
| RDH13 | Protein | uniprot:Q8NBN7 | |
| CP3A7 | Protein | uniprot:P24462 | |
| 11-cis-retinyl-palmitate hydrolase | Protein | brenda:3.1.1.63 | |
| DHRS9 | Protein | uniprot:Q9BPW9 | |
| RPE65 | Protein | uniprot:Q16518 |
References
- Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells. Blaner WS, Das SR, Gouras P, Flood MT. J Biol Chem. 1987 Jan 5;262(1):53–8. PubMed Europe PMC Scholia
- Rat liver retinyl palmitate hydrolase activity. Relationship to cholesteryl oleate and triolein hydrolase activities. Blaner WS, Prystowsky JH, Smith JE, Goodman DS. Biochim Biophys Acta. 1984 Jul 26;794(3):419–27. PubMed Europe PMC Scholia
- The multifaceted nature of retinoid transport and metabolism. Li Y, Wongsiriroj N, Blaner WS. Hepatobiliary Surg Nutr. 2014 Jun;3(3):126–39. PubMed Europe PMC Scholia
- Allosteric modulation of the substrate specificity of acyl-CoA wax alcohol acyltransferase 2. Arne JM, Widjaja-Adhi MAK, Hughes T, Huynh KW, Silvaroli JA, Chelstowska S, et al. J Lipid Res. 2017 Apr;58(4):719–30. PubMed Europe PMC Scholia