NRP1-triggered signaling in pancreatic cancer (WP5144)
Homo sapiens
This pathway model provides a holistic overview of the various signalling pathways which promote pancreatic cancer with the direct involvment of neuropilin 1, commonly known as NRP1. The multifaceted role of NRP1 in pancreatic ductal adenocarcinoma (PDAC) constitutes it as a promising therapeutic target for the fatal disease. The curation of the model was conducted by using the review done by Matkar et al. as a starting point and combining information gathered by several other studies investigating this particular phenomenon.
Authors
Konstantina Pandi , Martina Summer-Kutmon , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
CPTAC PancCanNetAnnotations
Disease Ontology
pancreatic adenocarcinomaPathway Ontology
disease pathway cancer pathway signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Zinc | Metabolite | hmdb:HMDB0015532 | |
| COL1A2 | GeneProduct | ensembl:ENSG00000164692 | |
| NRP1 | GeneProduct | ensembl:ENSG00000099250 | |
| COL1A1 | GeneProduct | ensembl:ENSG00000108821 | |
| RELA | GeneProduct | uniprot:Q04206 | |
| AKT1 | Protein | uniprot:P31749 | |
| RAC1 | Protein | uniprot:P63000 | |
| SMAD2 | Protein | uniprot:Q15796 | |
| EGF | Protein | uniprot:P01133 | |
| NRP1 | Protein | uniprot:O14786 | |
| PLXNA2 | Protein | uniprot:O75051 | |
| MET | Protein | uniprot:P08581 | |
| SMAD4 | Protein | uniprot:Q13485 | |
| AKT3 | Protein | uniprot:Q9Y243 | |
| SNAI1 | Protein | uniprot:O95863 | |
| MEK1 | Protein | uniprot:Q02750 | |
| CDH5 | Protein | uniprot:P33151 | |
| NFKB1 | Protein | uniprot:P19838 | |
| MMP9 | Protein | uniprot:P14780 | |
| SEMA3A | Protein | uniprot:Q14563 | |
| PI3K | Protein | eccode:2.7.1.137 | |
| PLXNA4 | Protein | uniprot:Q9HCM2 | |
| cyclin E1 | Protein | uniprot:P24864 | |
| CDK2 | Protein | uniprot:P24941 | |
| ZIP4 | Protein | uniprot:Q6P5W5 | |
| CD31 | Protein | uniprot:P16284 | |
| ERK1 | Protein | uniprot:P27361 | |
| p27 | Protein | uniprot:P46527 | |
| CDH1 | Protein | uniprot:O14646 | |
| MMP2 | Protein | uniprot:P08253 | |
| SMAD3 | Protein | uniprot:P84022 | |
| HGF | Protein | uniprot:P14210 | |
| NRP1 | Protein | ensembl:ENSG00000099250 | |
| CDH2 | Protein | uniprot:O14647 | |
| GSK3 | Protein | uniprot:P49840 | |
| FAK | Protein | uniprot:Q05397 | |
| AKT2 | Protein | uniprot:P31751 | |
| PLXNA1 | Protein | uniprot:Q9UIW2 | |
| EGFR | Protein | uniprot:P00533 | |
| ERK2 | Protein | uniprot:P28482 | |
| MEK2 | Protein | uniprot:P36507 | |
| SRC | Protein | uniprot:P12931 | |
| p130Cas | Protein | uniprot:P56945 | |
| TGFBR1 | Protein | uniprot:P36897 | |
| TGFB3 | Protein | uniprot:P10600 | |
| TGFB1 | Protein | uniprot:P01137 | |
| TGFB2 | Protein | uniprot:P61812 | |
| TGFBR2 | Protein | uniprot:P37173 | |
| TGFBR3 | Protein | uniprot:Q03167 | |
| SNAI2 | Protein | uniprot:O43623 | |
| CTGF | Protein | uniprot:P29279 | |
| VEGFR1 | Protein | uniprot:P17948 | |
| VEGFA | Protein | uniprot:P15692 | |
| VEGFR2 | Protein | uniprot:P35968 | |
| NFKB2 | Protein | uniprot:Q00653 | |
| RELB | Protein | uniprot:Q01201 | |
| REL | Protein | uniprot:Q04864 | |
| cyclin E2 | Protein | uniprot:O96020 |
References
- Association of axon guidance factor semaphorin 3A with poor outcome in pancreatic cancer. Müller MW, Giese NA, Swiercz JM, Ceyhan GO, Esposito I, Hinz U, et al. Int J Cancer. 2007 Dec 1;121(11):2421–33. PubMed Europe PMC Scholia
- Hepatocyte growth factor-mediated cell invasion in pancreatic cancer cells is dependent on neuropilin-1. Matsushita A, Götze T, Korc M. Cancer Res. 2007 Nov 1;67(21):10309–16. PubMed Europe PMC Scholia
- The role of neuropilins in cell signalling. Zachary IC, Frankel P, Evans IM, Pellet-Many C. Biochem Soc Trans. 2009 Dec;37(Pt 6):1171–8. PubMed Europe PMC Scholia
- The ZIP4 pathway in pancreatic cancer. Donahue T, Hines OJ. Cancer Biol Ther. 2010 Feb;9(3):243–5. PubMed Europe PMC Scholia
- VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells. Yoshida A, Shimizu A, Asano H, Kadonosono T, Kondoh SK, Geretti E, et al. Biol Open. 2015 Jul 24;4(9):1063–76. PubMed Europe PMC Scholia
- Neuropilin-1 is associated with clinicopathology of gastric cancer and contributes to cell proliferation and migration as multifunctional co-receptors. Li L, Jiang X, Zhang Q, Dong X, Gao Y, He Y, et al. J Exp Clin Cancer Res. 2016 Jan 22;35:16. PubMed Europe PMC Scholia
- Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma. Matkar PN, Singh KK, Rudenko D, Kim YJ, Kuliszewski MA, Prud’homme GJ, et al. Oncotarget. 2016 Oct 25;7(43):69489–506. PubMed Europe PMC Scholia
- Jack of many trades: Multifaceted role of neuropilins in pancreatic cancer. Matkar PN, Jong ED, Ariyagunarajah R, Prud’homme GJ, Singh KK, Leong-Poi H. Cancer Med. 2018 Oct;7(10):5036–46. PubMed Europe PMC Scholia
- The miR-141/neuropilin-1 axis is associated with the clinicopathology and contributes to the growth and metastasis of pancreatic cancer. Ma L, Zhai B, Zhu H, Li W, Jiang W, Lei L, et al. Cancer Cell Int. 2019 Sep 27;19:248. PubMed Europe PMC Scholia