Nucleotide excision repair in xeroderma pigmentosum (WP5114)

Homo sapiens

Authors

Natalie Hinkova , Friederike Ehrhart , Egon Willighagen , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Rare Diseases

Annotations

Pathway Ontology

DNA repair pathway nucleotide excision repair pathway

Disease Ontology

xeroderma pigmentosum Cockayne syndrome

References

1. 3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins. Miao F, Bouziane M, Dammann R, Masutani C, Hanaoka F, Pfeifer G, et al. J Biol Chem. 2000 Sep 15;275(37):28433–8. PubMed Europe PMC Scholia
2. Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions. Vasquez KM, Christensen J, Li L, Finch RA, Glazer PM. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5848–53. PubMed Europe PMC Scholia
3. Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation. Rapić-Otrin V, McLenigan MP, Bisi DC, Gonzalez M, Levine AS. Nucleic Acids Res. 2002 Jun 1;30(11):2588–98. PubMed Europe PMC Scholia
4. The PCNA-RFC families of DNA clamps and clamp loaders. Majka J, Burgers PMJ. Prog Nucleic Acid Res Mol Biol. 2004;78:227–60. PubMed Europe PMC Scholia
5. UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Sugasawa K, Okuda Y, Saijo M, Nishi R, Matsuda N, Chu G, et al. Cell. 2005 May 6;121(3):387–400. PubMed Europe PMC Scholia
6. The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites. Kapetanaki MG, Guerrero-Santoro J, Bisi DC, Hsieh CL, Rapić-Otrin V, Levine AS. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2588–93. PubMed Europe PMC Scholia
7. CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome. Groisman R, Kuraoka I, Chevallier O, Gaye N, Magnaldo T, Tanaka K, et al. Genes Dev. 2006 Jun 1;20(11):1429–34. PubMed Europe PMC Scholia
8. RETRACTED: Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner. Moser J, Kool H, Giakzidis I, Caldecott K, Mullenders LHF, Fousteri MI. Mol Cell. 2007 Jul 20;27(2):311–23. PubMed Europe PMC Scholia
9. Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step. Mocquet V, Lainé JP, Riedl T, Yajin Z, Lee MY, Egly JM. EMBO J. 2008 Jan 9;27(1):155–67. PubMed Europe PMC Scholia
10. Cooperation of replication protein A with the ubiquitin ligase Rad18 in DNA damage bypass. Huttner D, Ulrich HD. Cell Cycle. 2008 Dec;7(23):3629–33. PubMed Europe PMC Scholia
11. Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. Ogi T, Limsirichaikul S, Overmeer RM, Volker M, Takenaka K, Cloney R, et al. Mol Cell. 2010 Mar 12;37(5):714–27. PubMed Europe PMC Scholia
12. DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA. Takedachi A, Saijo M, Tanaka K. Mol Cell Biol. 2010 Jun;30(11):2708–23. PubMed Europe PMC Scholia
13. Role of endonucleases XPF and XPG in nucleotide excision repair of platinated DNA and cisplatin/oxaliplatin cytotoxicity. Graf N, Ang WH, Zhu G, Myint M, Lippard SJ. Chembiochem. 2011 May 2;12(7):1115–23. PubMed Europe PMC Scholia
14. Differential contribution of XPC, RAD23A, RAD23B and CENTRIN 2 to the UV-response in human cells. Renaud E, Miccoli L, Zacal N, Biard DS, Craescu CT, Rainbow AJ, et al. DNA Repair (Amst). 2011 Aug 15;10(8):835–47. PubMed Europe PMC Scholia
15. The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells. Zlatanou A, Despras E, Braz-Petta T, Boubakour-Azzouz I, Pouvelle C, Stewart GS, et al. Mol Cell. 2011 Aug 19;43(4):649–62. PubMed Europe PMC Scholia
16. The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation. Fischer ES, Scrima A, Böhm K, Matsumoto S, Lingaraju GM, Faty M, et al. Cell. 2011 Nov 23;147(5):1024–39. PubMed Europe PMC Scholia
17. Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis. Liu L, Yin Y, Li Y, Prevedel L, Lacy EH, Ma L, et al. Cell Res. 2012 Aug;22(8):1258–69. PubMed Europe PMC Scholia
18. DDB2 promotes chromatin decondensation at UV-induced DNA damage. Luijsterburg MS, Lindh M, Acs K, Vrouwe MG, Pines A, van Attikum H, et al. J Cell Biol. 2012 Apr 16;197(2):267–81. PubMed Europe PMC Scholia
19. PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1. Pines A, Vrouwe MG, Marteijn JA, Typas D, Luijsterburg MS, Cansoy M, et al. J Cell Biol. 2012 Oct 15;199(2):235–49. PubMed Europe PMC Scholia
20. BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Tian F, Sharma S, Zou J, Lin SY, Wang B, Rezvani K, et al. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13558–63. PubMed Europe PMC Scholia
21. Mammalian transcription-coupled excision repair. Vermeulen W, Fousteri M. Cold Spring Harb Perspect Biol. 2013 Aug 1;5(8):a012625. PubMed Europe PMC Scholia
22. Role of the XPA protein in the NER pathway: A perspective on the function of structural disorder in macromolecular assembly. Fadda E. Comput Struct Biotechnol J. 2015 Dec 8;14:78–85. PubMed Europe PMC Scholia
23. Common TFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways. Okuda M, Nakazawa Y, Guo C, Ogi T, Nishimura Y. Nucleic Acids Res. 2017 Dec 15;45(22):13043–55. PubMed Europe PMC Scholia
24. The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damage. Menoni H, Wienholz F, Theil AF, Janssens RC, Lans H, Campalans A, et al. Nucleic Acids Res. 2018 Sep 6;46(15):7747–56. PubMed Europe PMC Scholia
25. SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair. Zhang H, Chen Z, Ye Y, Ye Z, Cao D, Xiong Y, et al. Nucleic Acids Res. 2019 Nov 4;47(19):10181–201. PubMed Europe PMC Scholia
26. XPA: DNA Repair Protein of Significant Clinical Importance. Borszéková Pulzová L, Ward TA, Chovanec M. Int J Mol Sci. 2020 Mar 22;21(6):2182. PubMed Europe PMC Scholia
27. Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly. Thakar T, Leung W, Nicolae CM, Clements KE, Shen B, Bielinsky AK, et al. Nat Commun. 2020 May 1;11(1):2147. PubMed Europe PMC Scholia
28. The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage. Kumar N, Raja S, Van Houten B. Nucleic Acids Res. 2020 Nov 18;48(20):11227–43. PubMed Europe PMC Scholia