MAPK signaling pathway (WP510)

Saccharomyces cerevisiae

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The MAPK/ERK pathway is a signal transduction pathway that couples intracellular responses to the binding of growth factors to cell surface receptors. In many cell types, activation of this pathway promotes cell division. Adapted from: http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=sce&mapno=04010

Authors

Nathan Salomonis , Bruce Conklin , Ron Shigeta , Thomas Kelder , Michiel Adriaens , Daniela Digles , Egon Willighagen , Nuno , Kristina Hanspers , Alex Pico , Finterly Hu , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

mitogen activated protein kinase signaling pathway

Participants

Label Type Compact URI Comment
GTP Metabolite cas:2564-35-4
GTP Metabolite cas:2564-35-4
GTP Metabolite cas:2564-35-4
GDP Metabolite cas:146-91-8
GDP Metabolite cas:146-91-8
GTP Metabolite cas:2564-35-4
GDP Metabolite cas:146-91-8
GDP Metabolite cas:146-91-8
Ste4 GeneProduct sgd:S000005738
Ste1 GeneProduct sgd:S000001126
Mlp1 GeneProduct sgd:S000001803
Msg5 GeneProduct sgd:S000004998
Wsc1,2,3 GeneProduct sgd:S000005534
Ste7 GeneProduct sgd:S000002318
Ssk2 GeneProduct sgd:S000005314
Ras2 GeneProduct sgd:S000005042
Ste11 GeneProduct sgd:S000004354
Hog1 GeneProduct sgd:S000004103
Ste11 GeneProduct sgd:S000004354
Cdc42 GeneProduct sgd:S000004219
Sho1 GeneProduct sgd:S000000920
Ctt1 GeneProduct sgd:S000003320
Swi4 GeneProduct sgd:S000000913
Rho1 GeneProduct sgd:S000006369
Ste5 scaffold GeneProduct sgd:S000002510
Mkk1 GeneProduct sgd:S000005757
Ste20 GeneProduct sgd:S000000999
Fus1 GeneProduct sgd:S000000532
Ssk1 GeneProduct sgd:S000003996
Kss1 GeneProduct sgd:S000003272
Mid2 GeneProduct sgd:S000004324
Pkc1 GeneProduct sgd:S000000201
Fus1 GeneProduct sgd:S000000532
MATalpha GeneProduct sgd:S000006108
Cdc24 GeneProduct sgd:S000000039
Ste2 GeneProduct sgd:S000001868
Mcm1 GeneProduct sgd:S000004646
Fks2 GeneProduct sgd:S000003264
Bkc1 GeneProduct sgd:S000003631
Mcm1 GeneProduct sgd:S000004646
Msn2 GeneProduct sgd:S000004640
Cdc42 GeneProduct sgd:S000004219
Fks1 GeneProduct sgd:S000004334
Ste7 GeneProduct sgd:S000002318
Ste20 GeneProduct sgd:S000000999
Pbs2 GeneProduct sgd:S000003664
Dig1 GeneProduct sgd:S000005970
Sln1 GeneProduct sgd:S000001409
Ste12 GeneProduct sgd:S000001126
Ypd1 GeneProduct sgd:S000002394
Ste20 GeneProduct sgd:S000000999
Tec1 GeneProduct sgd:S000000287
Ste18 GeneProduct sgd:S000003846
Bem1 GeneProduct sgd:S000000404
Ste3 GeneProduct sgd:S000001661
Glo1 GeneProduct sgd:S000004463
GPA1 GeneProduct sgd:S000001047
Dig1,2 GeneProduct sgd:S000005970
MATa GeneProduct sgd:S000002869
Rlm1 GeneProduct sgd:S000006010
Ste11 GeneProduct sgd:S000004354
Bni1 GeneProduct sgd:S000005215
Slt2 GeneProduct sgd:S000001072
Far1 GeneProduct sgd:S000003693
Sho1 GeneProduct sgd:S000000920
GPA1 GeneProduct sgd:S000001047
Ste4 GeneProduct sgd:S000005738
Ste18 GeneProduct sgd:S000003846

References

  1. Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Chen RE, Thorner J. Biochim Biophys Acta. 2007 Aug;1773(8):1311–40. PubMed Europe PMC Scholia