Orexin receptor pathway (WP5094)

Homo sapiens

Open in new tab Open in NDEx Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Orexin-stimulated reactions involving signal transduction mechanisms and downstream effectors associated with varied physiological outcomes

Authors

Dr. T. S. Keshava Prasad , Egon Willighagen , Eric Weitz , Kristina Hanspers , and Aishwarya Iyer

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway neurotransmitter metabolic pathway signaling pathway pertinent to the brain and nervous system

Participants
Query Drugst.One

Label Type Compact URI Comment
2-AG Metabolite kegg.compound:C13856
Glucose Metabolite kegg.compound:C00031
Cortisol Metabolite kegg.compound:C00735
Triglyceride Metabolite kegg.compound:C00422
cAMP Metabolite kegg.compound:C00575
IP3 Metabolite chebi:16595
Ca2+ Metabolite kegg.compound:C00076
DAG Metabolite chebi:88376
PIP2 Metabolite hmdb:HMDB0010032
PIP3 Metabolite chebi:16618
Glycerol Metabolite kegg.compound:C00116
Testosterone Metabolite kegg.compound:C00535
Cytochrome C Metabolite kegg.compound:C00125
IP2 Metabolite chebi:18156
Progesterone Metabolite kegg.compound:C00410
Epinephrine Metabolite kegg.compound:C00788
Glutamicacid uptake Metabolite kegg.compound:C00025
Glutamic acid Metabolite kegg.compound:C00025
PA Metabolite kegg.compound:C00416
AA Metabolite kegg.compound:C00219
PIK3R1 GeneProduct ncbigene:5295
HCRTR1 GeneProduct ncbigene:3061
HCRTR2 GeneProduct ncbigene:3062
GNAS GeneProduct refseq:NP_536350 [Pubmed:11600545] have shown that Ox-A stimulates HCRTR2 and induces molecular association of HCRTR2 and GNAS in human adult adrenals.
GNAI1 GeneProduct refseq:NP_002060 [Pubmed:11600545] have shown that Ox-A stimulates HCRTR2 and induces molecular association of HCRTR2 and GNAI1 in human adult adrenals.
HCRTR2 GeneProduct ncbigene:3062 [Pubmed:19793950] have shown that Ox-A stimulates HCRTR2 and induces downregulation of HCRTR2 mRNA within 6 hours of treatment on H295R adrenal cells.
HCRTR1 GeneProduct ncbigene:3061 [Pubmed:24333629] have shown that Ox-A/Ox-B stimulates HCRTR1/HCRTR2 and induces downregulation of HCRTR1 mRNA in rat anterior pituitary cells.
HCRTR2 GeneProduct ncbigene:3062 [Pubmed:24333629] have shown that Ox-A/B stimulates HCRTR2 and induces upregulation of HCRTR2 mRNA in rat anterior pituitary cells.
CNR1 GeneProduct ncbigene:3062
CASP3 GeneProduct ncbigene:836
HIF1A GeneProduct ncbigene:3091 [Pubmed:21239965] have shown that Ox-A stimulates HCRTR1 and induces upregulation of HIF1A protein in rat hippocampal neurons.
VHL GeneProduct ncbigene:7428 [Pubmed:18006690] have shown that Ox-A stimulates HCRTR1 and induces downregulation of VHL protein in HEK293 cells and rat hypothalamus.
HIF1A GeneProduct ncbigene:3091 [Pubmed:18006690] have shown that Ox-A stimulates HCRTR1 and induces activation of HIF1A in HEK293 cells and rat hypothalamus.
[Pubmed:28886081] have shown that Ox-A stimulates HCRTR1 and induces translocation of HIF1A from cytoplasm to nucleus in HepG2 cells.
PTPN11 GeneProduct ncbigene:5781 [Pubmed:19661287] have shown that Ox-A stimulates HCRTR1 and induces activation of PTPN11 in CHO-OX1 cells.
[Pubmed:18198212] have shown that Ox-A stimulates HCRTR1 and induces molecular association of HCRTR1 and PTPN11 in CHO-hOX1R cells.
PIK3R2 GeneProduct ncbigene:5296
HCRTR1 GeneProduct ncbigene:3061 [Pubmed:26459696] have shown that Ox-A stimulates HCRTR1 and induces upregulation of HCRTR1 mRNA in H295R adrenocorticoid cells.
HCRTR1 GeneProduct ncbigene:3061 [Pubmed:26220343] have shown that Ox-A stimulates HCRTR1 and induces upregulation of HCRTR1 mRNA in LNCaP cells.
SLC2A1 GeneProduct ncbigene:6513 [Pumed:26549689] have shown that Ox-A stimulates HCRTR1 and induces upregulation of SLC2A1 protein in a PI3K-AKT-MTRO dependent manner in Hep3B cells.
PRKCA GeneProduct ncbigene:5578 [Pubmed: 27837432] have shown that Orexin-A stimulates OX1R and induces an upregulation of PRKCA protein in astrocytes of Neonatal Sprague-Dwaley rats.
MAPK1 GeneProduct ncbigene:5594 [Pubmed: 27837432] have shown that Orexin-A stimulates OX1R and induces an upregulation of MAPK1 protein in astrocytes of Neonatal Sprague-Dwaley rats.
MAPK3 GeneProduct ncbigene:5595 [Pubmed: 27837432] have shown that Orexin-A stimulates OX1R and induces an upregulation of MAPK3 protein in astrocytes of Neonatal Sprague-Dwaley rats.
SLC1A2 GeneProduct ncbigene:6506 [Pubmed: 27837432] have shown that Orexin-A stimulates OX1R and induces an upregulation of SLC1A2 protein in astrocytes of Neonatal Sprague-Dwaley rats.
MAPK9 Protein refseq:NP_002743 [Pubmed:23907013] have shown that Ox-a stimulates HCRTR1 and induces phosphorylation of MAPK9 in 3T3-L1 adipocytes.
[Pubmed: 16282319] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MAPK9 at Thr183 in CHO-OX1R cells
[Pubmed:25857454] have shown that Ox-a stimualtes HCRTR1 and induces phosphorylation of MAPK9 at Thr183 in a GNAQ dependent manner in CHO cells.
MAPK3 Protein refseq:NP_002737 [Pubmed:15683363] have shown that OxA stimulates HCRTR1 and induces phosphorylation of MAPK3 at Thr202 and Tyr204 in MEK cells.
MAP2K2 Protein refseq:NP_109587 [Pubmed:25278019] have shown that Ox-A/B stimulates HCRTR1 and/or HCRTR2 and induces phosphorylation of MAP2K2 at Ser216 and Ser222 under influence of calcium influx in N41 neuronal cells.
NPFFR1 Protein ncbigene:64106 [Pubmed:31091547] have shown that Ox-A stimulate HCRTR1/2 and induce upregulation of NPFFR1 mRNA in rat brain.
OPRK1 Protein ncbigene:4986
MAPK8 Protein ncbiprotein:NP_620637.1 [Pubmed:23907013] have shown that Ox-a stimulates HCRTR1 and induces phosphorylation of MAPK8 in 3T3-L1 adipocytes.
[Pubmed: 16282319] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MAPK8 at Thr183 in CHO-OX1R cells
[Pubmed:25857454] have shown that Ox-a stimualtes HCRTR1 and induces phosphorylation of MAPK8 at Thr183 in a GNAQ dependent manner in CHO cells.
MAPK14 Protein refseq:NP_001306 [Pubmed:23907013] have shown that Ox-a stimulates HCRTR1 and induces phosphorylation of MAPK14 in 3T3-L1 adipocytes.
[Pubmed:16282319] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MAPK14 at Thr180 and Tyr182 in CHO-OX1 cells.
MAPK1 Protein refseq:NP_002736 [Pubmed:15683363] have shown that OxA stimulates HCRTR1 and induces phosphorylation of MAPK1 at Thr183 and Tyr185 in MEK cells.
CREB1 Protein refseq:NP_604391 [Pubmed:22652455] have shown that Ox-B stimulates HCRTR2 and induces phosphorylation of CREB1 at Ser133 in a PKC dependent manner in CHO-OXR2 cells.
PDPK1 Protein refseq:NP_001248745 [Pubmed:18162514] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PDK1 at Ser241 in InR1-G9 cell line.
AKT1 Protein ncbiprotein:NP_005154.2 [Pubmed:18162514] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of AKT1 at Ser473 in InR1-G9 cell line
[Pubmed:26459696] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of AKT1 at Ser473 in a PI3K dependent manner in H295R adrenocorticoid cells
FOXO1 Protein refseq:NP_002006 [Pubmed:18162514] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of FOXO1 at Ser256 in InR1-G9 cell line.
PI3KCatalytic Protein refseq:NP_001265478 [Pubmed:18162514] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PDK1 at Ser241 in InR1-G9 cell line.
MAP2K1 Protein refseq:NP_002746 [Pubmed:25278019] have shown that Ox-A/B stimulates HCRTR1 and/or HCRTR2 and induces phosphorylation of MAP2K1 at Ser218 and Ser222 under influence of calcium influx in N41 neuronal cells.
GNAQ Protein refseq:NP_002063 [Pubmed:25857454] have shown that Ox-A stimulates HCRTR1 and induces activation of GNAQ in CHO cells.
[Pubmed:11600545] have shown that Ox-A stimulates HCRTR2 and induces molecular association of HCRTR2 and GNAQ in human adult adrenals.
PKA Protein ncbigene:5578 [Pubmed:18488139] have shown that Ox-A stimulates HCRTR1 and induces the translocation of PRKCA from cytosol to plasma membrane in CHO cell lines.
STAR Protein ncbigene:6770 [Pubmed: 18450961]have shown that Ox-A or Ox-B stimulates HCRTR1 and induces the upregulation of STAR protein mediated through ERK1/2 dependent and p38 dependent MAPK cascades in human H295R adrenal cells.
STAR Protein ncbigene:6770 [Pubmed:18450961]have shown that Ox-A or Ox-B stimulates HCRTR1 and induces upregulation of STAR mRNA through MAPK cascades in human H295R adrenocortical cells.
[Pubmed:19460850] have shown that Ox-A or Ox-B stimulates HCRTR1 and induces upregulation of STAR mRNA in H295R adernocortical cells.
BGLAP Protein refseq:NP_954642 [Pubmed:19020772] have shown that Ox-B stimulates HCRTR1 and induces upregulation of BGLAP protein in rat calvarial osteoblast-like cells.
CGA Protein ncbigene:1081 [Pubmed:11600545] have shown that Ox-A stimulates HCRTR2 and induces molecular association of HCRTR2 and GNAI1 in human adult adrenals.
LHB Protein ncbigene:3972 [Pubmed:24333629] have shown that Ox-A/B stimulate HCRTR1/2 and induces upregulation of LHB in rat anterior pituitary cells.
FSHB Protein ncbigene:2488 [Pubmed:24333629] have shown that Ox-A/B stimulate HCRTR1/2 and induces upregulation of FSHB in rat anterior pituitary cells.
MAPK7 Protein refseq:NP_620602 [Pubmed:19460850] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MAPK7 at Thr218 and Tyr220 in H295R(Human) adrenocortical cells.
ARRB1 Protein ncbiprotein:NP_004032.2 [Pubmed:21378163] have shown that Ox-A stimulates HCRTR1 and induces molecular association between HCRTR1 and ARRB1 in HEK293T cells.
HCRTR1 Protein ncbigene:3061 [Pubmed:19661287] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of HCRTR1 at Tyr83 and Tyr358 in CHO-OX1 cells.
ARRB1 Protein refseq:NP_004032 [Pubmed:11299310] have shown that Ox-A stimulates HCRTR1 and induces translocation of HCRTR1-ARRB1 complex from plasma membrane to endosome in CHO cells.
ARRB2 Protein refseq:NP_001244257 [Pubmed:21378163] have shown that Ox-A stimulates HCRTR1 and induces molecular association between HCRTR1 and ARRB2 in HEK293T cells.
ARRB2 Protein refseq:NP_001244257 [Pubmed:28487995] have shown that Ox-A/Ox-B stimulate HCRTR2 and induce molecular association of HCRTR2 and ARRB2 in HEK293 cells.
ARRB2 Protein refseq:NP_001244257 [Pubmed:15683363] have shown that OxA stimulates HCRTR1 and induces translocation of HCRTR1-ARRB2 complex from plasma membrane to acidic endosomes in HEK293 cells.
L-typeCalciumchannels Protein refseq:NP_001265478 [Pubmed:18162514] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PDK1 at Ser241 in InR1-G9 cell line.
TH Protein refseq:NP_954986 [Pubmed:23635422] have shown that Ox-A/B stimulate HCRTR1/2 and induce phosphorylation of TH at Ser40 in bovine adrenal medulla cells.
Voltage-gatedCa2+ and Na+channels Protein refseq:NP_001265478 [Pubmed:18162514] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PDK1 at Ser241 in InR1-G9 cell line.
CCK Protein ncbigene:2688 [Pubmed:12943684] have shown that Ox-A stimulates HCRTR1 and HCRTR2 and induces the upregulation of CCK in STC1 cells.
CCK Protein ncbigene:885 [Pubmed:12943684] have shown that Ox-A stimulates HCRTR1 and HCRTR2 and induces the upregulation of CCK in STC1 cells
GH1 Protein ncbigene:2688 [Pubmed:14610299] have shown that Ox-B stimulates HCRTR2 and induces upregulation of GH1 protein in ovine somatotropes.
CASP7 Protein refseq:NP_620637 [Pubmed:23907013] have shown that Ox-a stimulates HCRTR1 and induces phosphorylation of MAPK8 in 3T3-L1 adipocytes.
[Pubmed: 16282319] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MAPK8 at Thr183 in CHO-OX1R cells
[Pubmed:15310763] have shown that Ox-A/B stimulates HCRTR1 and induces activation of CASP7 in HT29-D4 cells.
PLCD1 Protein ncbigene:5333 [Pubmed:16141359] have shown that Ox-A stimulates HCRTR1 and induces the translocation of PLCD1 from plasma membrane to cytoplasm in CHO cells.
PRKCE Protein ncbigene:5581 [Pubmed:16141359] have shown that Ox-A stimulates HCRTR1 and induces the translocation of PRKCE from plasma membrane to cytosol in CHO cell lines.
PRKCZ Protein ncbigene:5590
GCG Protein ncbigene:2641 [Pubmed:18162514] have shown that Ox-A stimulates HCRTR1 and induces downregulation of GCG protein in InR-G9 cells.
PRKCA Protein ncbigene:5578 [Pubmed:20621130] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PRKCA at Thr638 in HEK OX1R cells.
GRIA1 Protein ncbigene:2890 [Pubmed: 19028455] have shown that Ox-A stimulates HCRTR1 and induces upregulation of GRIA1 protein in rat prefrontal cortex-striatum coculture.
PRKCD Protein ncbigene:5580 [Pubmed:20621130] have shown that OX-A stimulates HCRTR1 and induces phosphorylation of PRKCD at Thr505 in HEKOX1R cells.
PRKCB Protein ncbigene:5579 [Pubmed:20621130] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PRKCB at Thr641 in HEK OX1R cells.
PRKD1 Protein refseq:NP_001316998 [Pubmed:20621130] have shown that OX-A stimulates HCRTR1 and induces phosphorylation of PRKD1 at Ser916 in HEKOX1R cells.
PRKD3 Protein ncbiprotein:NP_005804.1 [Pubmed:20621130] have shown that OX-A stimulates HCRTR1 and induces phosphorylation of PRKD3 at Ser744/748 in HEKOX1R cells.
ARRB1 Protein refseq:NP_004032 [Pubmed:28487995] have shown that Ox-A/Ox-B stimulate HCRTR2 and induce molecular association of HCRTR2 and ARRB1 in HEK293 cells.
SLC2A4 Protein ncbigene:6517 [Pubmed:23907013] have shown that Ox-A stimulates HCRTR1 and induces upregulation of SLC2A4 mRNA in 3T3-L1 adipocytes.
ADIPOQ Protein ncbigene:9370 [Pubmed:21505958] have shown that Ox-A stimulates HCRTR1/HCRTR2 and induces upregulation of ADIPOQ protein in a PPARG dependent manner in 3T3-L1 adipocytes and primary adipocytes from wistar rats.
PLD1 Protein ncbigene:5337 [Pubmed:21718304] have shown that Ox-A stimulates HCRTR1 and induces activation of PLD1 in a PRKCD dependent manner in CHO-OxR1 cells.
BMP7 Protein ncbigene:655 [Pubmed:21982708] have shown that Ox-A stimulates HCRTR1 and induces upregulation of BMP7 mRNA in C3H10T1/2 cells.
BMPR1A Protein ncbigene:657 [Pubmed:21982708] have shown that Ox-A stimulates HCRTR1 and induces upregulation of BMPR1A mRNA in C3H10T1/2 cells.
SMAD1 Protein refseq:NP_001341740 [Pubmed:21982708] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of SMAD1 at Ser463 downstream of BMPR1A in C3H10T1/2 cells.
SMAD5 Protein refseq:NP_001001419 [Pubmed:21982708] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of SMAD5 at Ser465 downstream of BMPR1A in C3H10T1/2 cells.
DYNLT1 Protein refseq:NP_006510 [Pubmed:22028875] have shown that Ox-A stimulates HCRTR1 and induces molecular association between HCRTR1 and DYNLT1 in HEK293 cells.
DYNLT3 Protein ncbigene:6990 [Pubmed:22028875] have shown that Ox-A stimulates HCRTR1 and induces molecular association between HCRTR1 and DYNLT1 in HEK293 cells.
PRKAA1 Protein refseq:NP_996790 [Pubmed:24068427] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PRKAA1 at Thr172 in a Camkkbeta-Calcium dependent manner in rat hypothalamic nuclear neurons.
CAMKK2 Protein ncbigene:10645 [Pubmed:24068427] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PRKAA1 at Thr172 in a Camkkbeta-Calcium dependent manner in rat hypothalamic nuclear neurons.
NPY Protein ncbigene:4852 [Pubmed:24068427] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PRKAA1 at Thr172 in a Camkkbeta-Calcium dependent manner in rat hypothalamic nuclear neurons.
GHRL Protein ncbigene:51738 [Pubmed:24794976] have shown that Ox-A stimulates HCRTR1 and induces downregulation of GHRL protein in mouse osteoblast and adipocyte.
LEP Protein ncbigene:3952 [Pubmed:24794976] have shown that Ox-A stimulates HCRTR1 and induces downregulation of LEP protein in mouse serum.
MTOR Protein ncbiprotein:NP_004949.1 [Pubmed:24807827] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MTOR at Ser2481 in a PI3K-AKT dependent manner in rat hepatocytes.
RPS6 Protein refseq:NP_001001 [Pubmed:25278019] have shown that OX-A/B stimulates HCRTR1 and/or HCRTR2 and induces phosphorylation of RPS6 on Ser235/236 and Ser240/244 under the lysosome v-ATPase-RAG-GTPase pathway activating MTORC1 in HEK293T and N41 neural cells.
RPS6KB1 Protein refseq:NP_003152 [Pubmed:25278019] have shown that OX-A/B stimulates HCRTR1 and/or HCRTR2 and induces phosphorylation of RPS6KB1 on Thr389 under the lysosome v-ATPase-RAG-GTPase pathway activating MTORC1 in HEK293T and N41 neural cells.
EIF4B Protein refseq:NP_001287750 [Pubmed:25278019] have shown that OX-A/B stimulates HCRTR1 and/or HCRTR2 and induces phosphorylation of EIF4B on Ser422 under the lysosome v-ATPase-RAG-GTPase pathway activating MTORC1 in HEK293T and N41 neural cells.
RPS6KA1 Protein refseq:NP_002944 [Pubmed:25278019] have shown that Ox-A/B stimulates HCRTR1 and/or HCRTR2 and induces phosphorylation of RPS6KA1 at Ser380 in a MEK1/2 dependent manner under influence of calcium influx in N41 neuronal cells.
MTOR Protein ncbigene:2475 [Pubmed:25278019] have shown that OX-A/B stimulates HCRTR1 and/or HCRTR2 and induces activation of MTOR in HEK293T and N41 neural cells.
RRAGC Protein ncbigene:64121 [Pubmed:25278019] have shown that OX-A/B stimulates HCRTR1 and/or HCRTR2 and induces activation of RRAGC in HEK293T and N41 neural cells.
DAGLA Protein ncbigene:747 [Pubmed:33613258] have shown that Ox-A stimulates HCRTR1 and induces activation of DAGLA in TH positive neurons in mice.
CASP9 Protein refseq:NP_001220 [Pubmed:25515760] have shown that Ox-A stimulates HCRTR1 and induces inhibition of CASP9 in a MAPK1/3 dependent manner in SGC-7901 cells.
EIF4EBP1 Protein refseq:NP_004086 [Pubmed:26064108] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of EIF4EBP1 at Thr37 and Thr46 in a MTOR mediated manner in H295R cells.
NFE2L2 Protein ncbigene:4780 [Pubmed:26170736] have shown that Ox-A stimulates HCRTR1/2 and induces upregulation of NFE2L2 protein in HUVECs.
NFE2L2 Protein ncbigene:4780 [Pubmed:26170736] have shown that Ox-A stimulates HCRTR1/2 and induces upregulation of NFE2L2 protein in HUVECs.
[Pubmed:26170736] have shown that Ox-A stimulates HCRTR1/2 and induces activation of NFE2L2 in HUVECs.
CASP3 Protein ncbiprotein:NP_620637.1 [Pubmed:24382962] have shown that Ox-A stimulates HCRTR1 and induces inhibition of CASP3 in a PI3K-AKT dependent pathway in INS1 cells.
MAPK3 Protein ncbiprotein:NP_002737.2 [Pubmed:27071101] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MAPK3 at Thr202 and Tyr204 in mouse POMC neurons.
MAPK1 Protein refseq:NP_002736 [Pubmed:27071101] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MAPK1 at Thr185 and Tyr187 in mouse POMC neurons.
STAT3 Protein refseq:NP_001356441 [Pubmed:27071101] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of STAT3 at Ser727 downstream of MAPK1/3 in mouse POMC neurons.
POMC Protein ncbigene:5443 [Pubmed:27071101] have shown that Ox-A stimulates HCRTR1 and induces downregulation of POMC mRNA in a MAPK1/3-STAT3 dependent manner in mouse POMC cells.
POMC Protein ncbiprotein:5443 [Pubmed:27071101] have shown that Ox-A stimulates HCRTR1 and induces downregulation of POMC protein in a MAPK1/3-STAT3 dependent manner in mouse POMC cells.
GNA11 Protein ncbigene:2767 [Pubmed:27237973] have shown that Ox-A/B stimulates HCRTR1 and induces molecular association of HCRTR1 and GNA11 in CHO-K1 cells.
PDHB Protein ncbigene:5162 [Pubmed:26549689] have shown that OX-A stimulates HCRTR1 and induces upregulation of PDHB mRNA in Hep3B cells.
SGK1 Protein ncbigene:6446 [Pubmed:29145494] have shown that Ox-A stimulates HCRTR1 and induces upregulation of SGK1 mRNA in GT1-7 cells.
HCRT Protein ncbigene:3060 [Pubmed:11600545] have shown that Ox-A stimulates HCRTR2 and induces molecular association of HCRTR2 and GNAI1 in human adult adrenals.
RUNX2 Protein ncbigene:860 [Pubmed:29999239] have shown that Ox-A stimulates HCRTR1 and induces upregulation of RUNX2 protein in a PKD/MAPK14 dependent manner in MC3T3-E1 cells.
COX2 Protein ncbigene:6775079 [Pubmed:18378017] have shown that Ox-A stimulates HCRTR1 and induces upregulation of COX2 protein in rat gastric mucosa.
GNRH1 Protein ncbigene:2796 [Pubmed:31091547] have shown that Ox-A stimulates HCRTR1 and induces downregulation of GNRH1 mRNA in rats.
NPVF Protein ncbigene:64111 [Pubmed:31091547] have shown that Ox-A stimulate HCRTR1/2 and induce upregulation of NVPF mRNA in rat brain.
IL6 Protein ncbigene:3569 [Pubmed:30142537] have shown that Ox-A stimulates HCRTR1 and induces downregulation of IL6 protein in TNF alpha treated fibroblast-like synoviocytes.
CXCL8 Protein ncbigene:3576 [Pubmed:30142537] have shown that Ox-A stimulates HCRTR1 and induces downregulation of CXCL8 protein in TNF alpha treated fibroblast-like synoviocytes.
TNF Protein ncbigene:7124 [Pubmed:31106596] have shown that Ox-A stimulates HCRTR1 and induces downregulation of TNF protein in HBx transfected L-02 and MIHA hepatocytes.
IL1B Protein ncbigene:3553 [Pubmed:32539736] have shown that Ox-A stimulates HCRTR2 and induces downregulation of IL1B protein in a CAMKK2/PRKAA mediated manner in intacerebral hemorrhagic mouse brain.
IL9 Protein ncbigene:3578 [Pubmed:32539736] have shown that Ox-A stimulates HCRTR2 and induces downregulation of IL9 protein in a CAMKK2/PRKAA mediated manner in intacerebral hemorrhagic mouse brain.
IL4 Protein ncbigene:3565 [Pubmed:32539736] have shown that Ox-A stimulates HCRTR2 and induces upregulation of IL4 protein in a CAMKK2/PRKAA mediated manner in intacerebral hemorrhagic mouse brain.
IL10 Protein ncbigene:3586 [Pubmed:32539736] have shown that Ox-A stimulates HCRTR2 and induces upregulation of IL10 protein in a CAMKK2/PRKAA mediated manner in intacerebral hemorrhagic mouse brain.
NOX4 Protein ncbigene:50507 [Pubmed:31106596] have shown that Ox-A stimulates HCRTR1 and induces downregulation of NOX4 protein in HBx transfected L-02 and MIHA hepatocytes.
CXCL2 Protein ncbigene:2920 [Pubmed:31106596] have shown that Ox-A stimulates HCRTR1 and induces downregulation of CXCL2 protein in HBx transfected L-02 and MIHA hepatocytes.
PLA2G4A Protein ncbiprotein:5321

References

  1. Centrally administered orexin/hypocretin activates HPA axis in rats. Kuru M, Ueta Y, Serino R, Nakazato M, Yamamoto Y, Shibuya I, et al. Neuroreport. 2000 Jun 26;11(9):1977–80. PubMed Europe PMC Scholia
  2. Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade. Mazzocchi G, Malendowicz LK, Gottardo L, Aragona F, Nussdorfer GG. J Clin Endocrinol Metab. 2001 Feb;86(2):778–82. PubMed Europe PMC Scholia
  3. Visualizing differences in ligand-induced beta-arrestin-GFP interactions and trafficking between three recently characterized G protein-coupled receptors. Evans NA, Groarke DA, Warrack J, Greenwood CJ, Dodgson K, Milligan G, et al. J Neurochem. 2001 Apr;77(2):476–85. PubMed Europe PMC Scholia
  4. Orexin receptors couple to Ca2+ channels different from store-operated Ca2+ channels. Kukkonen JP, Akerman KE. Neuroreport. 2001 Jul 3;12(9):2017–20. PubMed Europe PMC Scholia
  5. Expression and coupling characteristics of the CRH and orexin type 2 receptors in human fetal adrenals. Karteris E, Randeva HS, Grammatopoulos DK, Jaffe RB, Hillhouse EW. J Clin Endocrinol Metab. 2001 Sep;86(9):4512–9. PubMed Europe PMC Scholia
  6. Orexin-B augments voltage-gated L-type Ca(2+) current via protein kinase C-mediated signalling pathway in ovine somatotropes. Xu R, Roh SG, Gong C, Hernandez M, Ueta Y, Chen C. Neuroendocrinology. 2003 Mar;77(3):141–52. PubMed Europe PMC Scholia
  7. Orexin 1 receptor messenger ribonucleic acid expression and stimulation of testosterone secretion by orexin-A in rat testis. Barreiro ML, Pineda R, Navarro VM, Lopez M, Suominen JS, Pinilla L, et al. Endocrinology. 2004 May;145(5):2297–306. PubMed Europe PMC Scholia
  8. A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism. Voisin T, El Firar A, Rouyer-Fessard C, Gratio V, Laburthe M. FASEB J. 2008 Jun;22(6):1993–2002. PubMed Europe PMC Scholia
  9. The signalling profile of recombinant human orexin-2 receptor. Tang J, Chen J, Ramanjaneya M, Punn A, Conner AC, Randeva HS. Cell Signal. 2008 Sep;20(9):1651–61. PubMed Europe PMC Scholia
  10. OX1 orexin/hypocretin receptor signaling through arachidonic acid and endocannabinoid release. Turunen PM, Jäntti MH, Kukkonen JP. Mol Pharmacol. 2012 Aug;82(2):156–67. PubMed Europe PMC Scholia
  11. OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Guo Y, Feng P. Exp Cell Res. 2012 Oct 1;318(16):2004–13. PubMed Europe PMC Scholia
  12. Mitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammation. Xiong X, White RE, Xu L, Yang L, Sun X, Zou B, et al. Stroke. 2013 Mar;44(3):764–70. PubMed Europe PMC Scholia
  13. Orexin-A activates hypothalamic AMP-activated protein kinase signaling through a Ca²⁺-dependent mechanism involving voltage-gated L-type calcium channel. Wu WN, Wu PF, Zhou J, Guan XL, Zhang Z, Yang YJ, et al. Mol Pharmacol. 2013 Dec;84(6):876–87. PubMed Europe PMC Scholia
  14. Orexin A and B in vitro modify orexins receptors expression and gonadotropins secretion of anterior pituitary cells of proestrous rats. Cataldi NI, Lux Lantos VAR, Libertun C. Regul Pept. 2014 Jan 10;188:25–30. PubMed Europe PMC Scholia
  15. Orexin A Affects INS-1 Rat Insulinoma Cell Proliferation via Orexin Receptor 1 and the AKT Signaling Pathway. Chen L, Zhao Y, Zheng D, Ju S, Shen Y, Guo L. Int J Endocrinol. 2013;2013:854623. PubMed Europe PMC Scholia
  16. Orexin A-mediated stimulation of 3β-HSD expression and testosterone production through MAPK signaling pathways in primary rat Leydig cells. Zheng D, Zhao Y, Shen Y, Chang X, Ju S, Guo L. J Endocrinol Invest. 2014 Mar;37(3):285–92. PubMed Europe PMC Scholia
  17. Effect of Orexin-A on Cortisol Secretion in H295R Cells via p70S6K/4EBP1 Signaling Pathway. Chang X, Zhao Y, Guo L. Int J Endocrinol. 2015;2015:405157. PubMed Europe PMC Scholia
  18. Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells. Kim MK, Park HJ, Kim SR, Choi YK, Bae SK, Bae MK. Korean J Physiol Pharmacol. 2015 Jul;19(4):327–34. PubMed Europe PMC Scholia
  19. Expression and potential role of the peptide orexin-A in prostate cancer. Valiante S, Liguori G, Tafuri S, Pavone LM, Campese R, Monaco R, et al. Biochem Biophys Res Commun. 2015 Sep 4;464(4):1290–6. PubMed Europe PMC Scholia
  20. G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells. Kukkonen JP. Biochem Biophys Res Commun. 2016 Aug 5;476(4):379–85. PubMed Europe PMC Scholia
  21. C-terminus of OX2R significantly affects downstream signaling pathways. Wang C, Xu C, Liu M, Pan Y, Bai B, Chen J. Mol Med Rep. 2017 Jul;16(1):159–66. PubMed Europe PMC Scholia
  22. Increased activity of the orexin system in the paraventricular nucleus contributes to salt-sensitive hypertension. Huber MJ, Fan Y, Jiang E, Zhu F, Larson RA, Yan J, et al. Am J Physiol Heart Circ Physiol. 2017 Dec 1;313(6):H1075–86. PubMed Europe PMC Scholia
  23. Orexin A but not orexin B regulates lipid metabolism and leptin secretion in isolated porcine adipocytes. Pruszynska-Oszmalek E, Kolodziejski PA, Kaczmarek P, Sassek M, Szczepankiewicz D, Mikula R, et al. Domest Anim Endocrinol. 2018 Apr;63:59–68. PubMed Europe PMC Scholia
  24. Orexin A Suppresses Oxidized LDL Induced Endothelial Cell Inflammation via MAPK p38 and NF-κB Signaling Pathway. Zhang H, Liang B, Li T, Zhou Y, Shang D, Du Z. IUBMB Life. 2018 Oct;70(10):961–8. PubMed Europe PMC Scholia
  25. Role of RF-amid Related Peptide-3 (RFRP-3) in Inhibitory Effect of Orexin A on Reproductive Function in the Animal Model of Male Wistar Rats. Hefshejanni JA, Khazali H. Exp Clin Endocrinol Diabetes. 2019 Oct;127(10):697–705. PubMed Europe PMC Scholia
  26. Orexin A-induced inhibition of leptin expression and secretion in adipocytes reducing plasma leptin levels and hypothalamic leptin resistance. Shin SK, Song SE, Oh JU, Hwang M, Cho HW, Bae JH, et al. Pflugers Arch. 2019 Dec;471(11–12):1407–18. PubMed Europe PMC Scholia
  27. Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice. Tunisi L, D’Angelo L, Fernández-Rilo AC, Forte N, Piscitelli F, Imperatore R, et al. Front Synaptic Neurosci. 2021 Feb 4;13:622405. PubMed Europe PMC Scholia