Nephrogenesis (WP5052)
Homo sapiens
This pathway describes the gene signaling pathways active in early nephrogenesis in human development. Mutations in essential genes can lead to development of CAKUT (congenital anomalies of the kidney and urinary tract).
Authors
Friederike Ehrhart and Eric WeitzActivity
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Cited In
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Organisms
Homo sapiensCommunities
Rare DiseasesAnnotations
Disease Ontology
kidney disease CAKUTPathway Ontology
Notch signaling pathway signaling pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
OSR1 | GeneProduct | ensembl:ENSG00000143867 | |
FGF20 | GeneProduct | ensembl:ENSG00000078579 | |
GREB1L | GeneProduct | ensembl:ENSG00000141449 | |
SIX2 | GeneProduct | ensembl:ENSG00000170577 | |
BMP7 | GeneProduct | ensembl:ENSG00000101144 | |
FOXD1 | GeneProduct | ensembl:ENSG00000251493 | |
TCF21 | GeneProduct | ensembl:ENSG00000118526 | |
MEIS1 | GeneProduct | ensembl:ENSG00000143995 | |
ALDH1A2 | GeneProduct | ensembl:ENSG00000128918 | |
RSPO1 | GeneProduct | ensembl:ENSG00000169218 | |
FGF8 | GeneProduct | ensembl:ENSG00000107831 | |
JAG1 | GeneProduct | ensembl:ENSG00000101384 | |
PAX2 | GeneProduct | ensembl:ENSG00000075891 | |
RSPO3 | GeneProduct | ensembl:ENSG00000146374 | |
WNT9B | GeneProduct | ensembl:ENSG00000158955 | |
WNT4 | GeneProduct | ensembl:ENSG00000162552 | |
LHX1 | GeneProduct | ensembl:ENSG00000274577 | |
WNT3A | GeneProduct | ensembl:ENSG00000154342 | |
NOTCH2 | GeneProduct | ensembl:ENSG00000134250 |
References
- Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, et al. Development. 2007 Feb;134(4):801–11. PubMed Europe PMC Scholia
- Renal hypodysplasia associates with a WNT4 variant that causes aberrant canonical WNT signaling. Vivante A, Mark-Danieli M, Davidovits M, Harari-Steinberg O, Omer D, Gnatek Y, et al. J Am Soc Nephrol. 2013 Mar;24(4):550–8. PubMed Europe PMC Scholia