nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell (WP5027)

Homo sapiens

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The pathway depicted how nsp1 from SARS-CoV 2 may inhibit translation in the host cell (Yuan S et al 2020, PubMed 33188728). nsp1 protein competes with the EIF3J subunit of the EIF3s complex for binding to the 40S ribosomal subunit. The resulted 43S pre-initiation complex can no longer load the mRNA from the host cell for starting translation.

Authors

Nhung Pham , Martina Summer-Kutmon , Egon Willighagen , Friederike Ehrhart , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

COVID-19

Annotations

Disease Ontology

viral infectious disease COVID-19 severe acute respiratory syndrome

Pathway Ontology

translation initiation pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
met-tRNAi Metabolite chebi:13145
EIF3B GeneProduct ncbigene:8662
EIF3H GeneProduct ncbigene:8667
EIF3I GeneProduct ncbigene:8668
EIF3G GeneProduct ncbigene:8666
EIF3D GeneProduct ncbigene:8664
EIF3J GeneProduct ncbigene:8669
EIF3E GeneProduct ncbigene:3646
EIF3C GeneProduct ncbigene:8663
EIF3A GeneProduct ncbigene:8661
EIF3F GeneProduct ncbigene:8665
EIF2S2 GeneProduct ncbigene:8894
EIF2S3 GeneProduct ncbigene:1968
EIF5 GeneProduct ncbigene:1983
EIF2S1 GeneProduct ncbigene:1965
EIF1A GeneProduct ncbigene:1964 Also known as EIF1AX
EIF1 GeneProduct ncbigene:10209
nsp1 Protein wikidata:Q90038952 wikidata Q90038952

References

  1. Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA. Yuan S, Peng L, Park JJ, Hu Y, Devarkar SC, Dong MB, et al. Mol Cell. 2020 Dec 17;80(6):1055-1066.e6. PubMed Europe PMC Scholia