Airway smooth muscle cell contraction (WP4962)
Homo sapiens
Signal transduction pathways involved in airway smooth muscle cell contraction. Based on [https://www.resmedjournal.com/article/S0954-6111(08)00096-6/fulltext figure 1 from Belaia et al.].
Authors
Angelcymak , Kristina Hanspers , Eric Weitz , Soukaina Boudllali , and Egon WillighagenActivity
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Cited In
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
signaling pathwayCell Type Ontology
bronchial smooth muscle cellDisease Ontology
allergic asthmaLabel | Type | Compact URI | Comment |
---|---|---|---|
Ca2+ | Metabolite | chebi:29108 | |
IP3 | Metabolite | chebi:16595 | |
PIP2 | Metabolite | chebi:18348 | |
DAG | Metabolite | chebi:18035 | |
cADPR | Metabolite | chebi:31445 | |
GTP | Metabolite | chebi:37565 | |
GDP | Metabolite | chebi:17552 | |
MYLK | GeneProduct | ensembl:ENSG00000065534 | |
CD38 | GeneProduct | ensembl:ENSG00000004468 | |
MYL | GeneProduct | ensembl:ENSG00000168530 | |
ROCK1 | GeneProduct | ensembl:ENSG00000067900 | Rho kinase |
PLCB1 | GeneProduct | ensembl:ENSG00000182621 | |
ITPR3 | GeneProduct | ensembl:ENSG00000096433 | |
MLCP | GeneProduct | ensembl:ENSG00000213639 | |
GDI | GeneProduct | ensembl:ENSG00000203879 | |
GNAQ | GeneProduct | ensembl:ENSG00000156052 | |
GCPR | GeneProduct | ensembl:ENSG00000169252 | GPCR |
PPP1R14A | GeneProduct | ensembl:ENSG00000167641 | |
RYR | GeneProduct | ensembl:ENSG00000196218 | |
RHOA | GeneProduct | ensembl:ENSG00000067560 | |
ROCK2 | GeneProduct | ensembl:ENSG00000134318 | Rho kinase |
Calmodulin | Protein | uniprot:G3V226 | |
PKC | Protein | ensembl:L7RSM7 | |
IL13 | Protein | ensembl:ENSG00000169194 | |
MLCP | Protein | ensembl:ENSG00000213639 | Myosin light chain phosphatase |
References
- Molecular mechanisms underlying airway smooth muscle contraction and proliferation: implications for asthma. Pelaia G, Renda T, Gallelli L, Vatrella A, Busceti MT, Agati S, et al. Respir Med. 2008 Aug;102(8):1173–81. PubMed Europe PMC Scholia