Unfolded protein response (WP4925)

Homo sapiens

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The unfolded protein response (UPR) pathway regulates and protects the cell from improperly folded protein overload in the endoplasmic reticulum (ER). UPR can result in the slowing of protein synthesis, which gives the cell time to translate more chaperones to help process the proteins. If the stress is too high, UPR can eventually trigger apoptosis.

Authors

Anna Baya Meuleman , Egon Willighagen , Friederike Ehrhart , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

endoplasmic reticulum stress - the unfolded protein response pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
BCL2 GeneProduct ensembl:ENSG00000171791
NFE2L2 GeneProduct ensembl:ENSG00000116044
PMAIP1 GeneProduct ensembl:ENSG00000141682
EIF2S1 GeneProduct ensembl:ENSG00000134001
CHOP GeneProduct ensembl:ENSG00000175197
TNFRSF10B GeneProduct ensembl:ENSG00000120889
ATF4 GeneProduct ensembl:ENSG00000128272
BBC3 GeneProduct ensembl:ENSG00000105327
GADD35 GeneProduct ensembl:ENSG00000087074
IRE1α GeneProduct ensembl:ENSG00000178607
MBTPS1 GeneProduct ensembl:ENSG00000140943
IL1B GeneProduct ensembl:ENSG00000125538
XBP1 GeneProduct ensembl:ENSG00000100219
BiP GeneProduct ensembl:ENSG00000044574
RTCB GeneProduct ensembl:ENSG00000100220
TXNIP GeneProduct ensembl:ENSG00000265972
MBTPS2 GeneProduct ensembl:ENSG00000012174
ATF6 GeneProduct ensembl:ENSG00000118217
BCL2L11 GeneProduct ensembl:ENSG00000153094
BID GeneProduct ensembl:ENSG00000015475
PERK GeneProduct ensembl:ENSG00000172071
p53 GeneProduct ensembl:ENSG00000141510
Caspase-8 Protein uniprot:A0A0A0MS31
Caspase-1 Protein uniprot:A0A1W2PRX7
Caspase-2 Protein uniprot:A0A087WYM1

References

  1. The Unfolded Protein Response and Cell Fate Control. Hetz C, Papa FR. Mol Cell. 2018 Jan 18;69(2):169–81. PubMed Europe PMC Scholia