Neuroinflammation (WP4919)

Homo sapiens

Neuroinflammation is inflammation specific to parts of the central nervous system. It can be triggered by external or internal factors, such as UV damage, inflammatory cytokines and oxidative stress. Stress on the cell leads to activation of inflammatory response pathways that involve several transcription factors such as AP-1 and NFkB, which will lead to the transcription of several proteins and/or cytokines.

Authors

Anna Baya Meuleman , Marvin Martens , and Egon Willighagen

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

stress response pathway regulatory pathway pertinent to the brain

Participants

Label Type Compact URI Comment
Calmodulin Metabolite chebi:3324
L-arginine Metabolite chebi:16467
NADPH Metabolite chebi:16474
Nitrate Metabolite chebi:48107
Ca2+ Metabolite chebi:29108
Nitrite Metabolite chebi:16301
NO Metabolite chebi:16480
O2 Metabolite chebi:15379
L-citrulline Metabolite chebi:57743
NADP+ Metabolite chebi:18009
H2O Metabolite chebi:15377
JNK GeneProduct ensembl:ENSG00000107643
COX2 GeneProduct ensembl:ENSG00000198712
IL-1B GeneProduct homologene:481
p50 GeneProduct ensembl:ENSG00000138303
p65 GeneProduct ensembl:ENSG00000173039
COX1 GeneProduct ensembl:ENSG00000198804
Nitrate reductase GeneProduct brenda:1.7.99.4
JUN GeneProduct ensembl:ENSG00000177606
FOS GeneProduct ensembl:ENSG00000170345
AKT GeneProduct hgnc:391
IKKα GeneProduct ensembl:ENSG00000213341
MAPK14 GeneProduct ensembl:ENSG00000112062
PI3K GeneProduct interpro:IPR000403
iNOS GeneProduct ensembl:ENSG00000007171
TNF-α GeneProduct homologene:496
MTOR GeneProduct ensembl:ENSG00000198793
IκBα GeneProduct ensembl:ENSG00000100906
TLR4 GeneProduct ensembl:ENSG00000136869

References

  1. Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults. Xing B, Bachstetter AD, Van Eldik LJ. J Mol Neurosci. 2015 Feb;55(2):509–18. PubMed Europe PMC Scholia
  2. Neuroinflammation pathways: a general review. Shabab T, Khanabdali R, Moghadamtousi SZ, Kadir HA, Mohan G. Int J Neurosci. 2017 Jul;127(7):624–33. PubMed Europe PMC Scholia
  3. NF-κB signaling in inflammation. Liu T, Zhang L, Joo D, Sun SC. Signal Transduct Target Ther. 2017;2:17023. PubMed Europe PMC Scholia