Purinergic signaling (WP4900)
Homo sapiens
Purinergic signaling is involved in several processes including neurologic, endocrine, and immune system signaling.
Authors
Friederike Ehrhart , Egon Willighagen , Eric Weitz , and Aishwarya IyerActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
nucleotide signaling via the purinergic P2Y receptors. nucleoside and nucleotide mediated signaling pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
5'-N-ethylcarboxamidoadenosine | Metabolite | pubchem.compound:3086599 | |
AMP | Metabolite | chebi:16027 | |
PSB 10 | Metabolite | pubchem.compound:10318703 | |
PSB 36 | Metabolite | chemspider:9864310 | 1-butyl-8-(3- noradamantyl)-3-(3-hydroxypropyl)xanthine 1-Butyl-3-(3-hydroxypropyl)-8-(tricyclo[3.3.1.03,7]non-3-yl)-3,7-dihydro-1H-purine-2,6-dione |
CP-532,903 | Metabolite | pubchem.compound:10479002 | |
2-Cl-IB-MECA | Metabolite | pubchem.compound:3035850 | |
SCH-58261 | Metabolite | pubchem.compound:176408 | |
BAY 60–6583 | Metabolite | pubchem.compound:11717831 | |
LPA | Metabolite | chebi:132742 | Lysophosphatidic acid |
SDZ WAG 994 | Metabolite | pubchem.compound:18755269 | |
MRE3008F20 | Metabolite | pubchem.compound:5310960 | |
UTP | Metabolite | chebi:15713 | |
HEMADO | Metabolite | pubchem.compound:10981286 | 2-(1-Hexynyl)-N-methyladenosine |
CVT-6883 | Metabolite | pubchem.compound:11270783 | |
Adenosine | Metabolite | chebi:16335 | |
ATL-146e | Metabolite | pubchem.compound:9805430 | |
Caffeine | Metabolite | chebi:27732 | |
UDP-glucose | Metabolite | chebi:46229 | |
Istradefylline | Metabolite | pubchem.compound:5311037 | |
8-Phenyl-1,3-dipropylxanthine | Metabolite | pubchem.compound:90477827 | |
MRS-1754 | Metabolite | pubchem.compound:6603931 | |
MRS-1220 | Metabolite | pubchem.compound:393595 | |
MRS-1334 | Metabolite | pubchem.compound:10324445 | |
CGS-21680 | Metabolite | pubchem.compound:3086599 | |
DPCPX | Metabolite | chebi:73282 | 8-Cyclopentyl-1,3-dipropylxanthine |
ZM-241,385 | Metabolite | pubchem.compound:176407 | |
Regadenoson | Metabolite | pubchem.compound:219024 | |
ATP | Metabolite | chebi:15422 | |
GR 79236 | Metabolite | pubchem.compound:9884817 | |
cAMP | Metabolite | chebi:17489 | |
CPX | Metabolite | pubchem.compound:1917 | 8-Cyclopentyl-1,3-dimethylxanthine |
2'-MeCCPA | Metabolite | pubchem.compound:122173097 | |
PSB-0788 | Metabolite | pubchem.compound:44186581 | |
MRS-3777 | Metabolite | pubchem.compound:11771279 | |
MRS-1706 | Metabolite | pubchem.compound:5139184 | |
Theophylline | Metabolite | chebi:28177 | |
UDP | Metabolite | chebi:58223 | |
IB-MECA | Metabolite | pubchem.compound:123683 | CF-101 |
MRS-3558 | Metabolite | pubchem.compound:11248240 | |
N-methyl-D-glucamine | Metabolite | chebi:59732 | |
ADP | Metabolite | chebi:16761 | |
N6-Cyclopentyladenosine | Metabolite | pubchem.compound:657378 | |
MRS-1523 | Metabolite | pubchem.compound:3661570 | |
PSB-1115 | Metabolite | pubchem.compound:5311479 | |
MRS-1191 | Metabolite | pubchem.compound:393594 | |
CCPA | Metabolite | pubchem.compound:123807 | |
SCH-442,416 | Metabolite | pubchem.compound:10668061 | |
VUF-5574 | Metabolite | pubchem.compound:4046493 | |
Gefapixant | Metabolite | pubchem.compound:24764487 | |
Opiranserin | Metabolite | pubchem.compound:71566778 | |
Ivermectin | Metabolite | pubchem.compound:9812710 | |
Zn(2+) | Metabolite | chebi:29105 | |
Suramin | Metabolite | pubchem.compound:5361 | |
PPADS | Metabolite | pubchem.compound:6093163 | pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid |
L-Glutathione | Metabolite | chebi:16856 | |
Ca(2+) | Metabolite | chebi:29108 | |
Mg(2+) | Metabolite | chebi:18420 | |
Cu(2+) | Metabolite | chebi:29036 | |
P2RY1 | GeneProduct | ensembl:ENSG00000169860 | |
ADORA3 | GeneProduct | ensembl:ENSG00000282608 | |
ADORA1 | GeneProduct | ensembl:ENSG00000163485 | |
P2RY14 | GeneProduct | ensembl:ENSG00000174944 | |
P2RY8 | GeneProduct | ensembl:ENSG00000182162 | |
GNAT3 | GeneProduct | ensembl:ENSG00000214415 | |
P2RX6 | GeneProduct | ensembl:ENSG00000099957 | |
P2RX5 | GeneProduct | ensembl:ENSG00000083454 | |
GNAI3 | GeneProduct | ensembl:ENSG00000065135 | |
P2RY13 | GeneProduct | ensembl:ENSG00000181631 | |
P2RY4 | GeneProduct | ensembl:ENSG00000186912 | |
P2RX4 | GeneProduct | ensembl:ENSG00000135124 | |
LPAR4 | GeneProduct | ensembl:ENSG00000147145 | P2RY9GPR23 |
P2RY10 | GeneProduct | ensembl:ENSG00000078589 | |
GNAO1 | GeneProduct | ensembl:ENSG00000087258 | |
GNAI1 | GeneProduct | ensembl:ENSG00000127955 | |
P2RY12 | GeneProduct | ensembl:ENSG00000169313 | |
GNAT1 | GeneProduct | ensembl:ENSG00000114349 | |
P2RX2 | GeneProduct | ensembl:ENSG00000187848 | |
P2RY2 | GeneProduct | ensembl:ENSG00000175591 | |
ADORA2B | GeneProduct | ensembl:ENSG00000170425 | |
PANX1 | GeneProduct | ensembl:ENSG00000110218 | |
GNAZ | GeneProduct | ensembl:ENSG00000128266 | |
P2RX7 | GeneProduct | ensembl:ENSG00000089041 | |
GNAT2 | GeneProduct | ensembl:ENSG00000134183 | |
P2RX1 | GeneProduct | ensembl:ENSG00000108405 | |
Gq/11 | GeneProduct | ncbigene:2767 | |
ADORA2A | GeneProduct | ensembl:ENSG00000128271 | |
P2RY11 | GeneProduct | ensembl:ENSG00000244165 | |
P2RY6 | GeneProduct | ensembl:ENSG00000171631 | |
LPAR6 | GeneProduct | ensembl:ENSG00000139679 | |
P2RX3 | GeneProduct | ensembl:ENSG00000109991 | |
Gi | GeneProduct | ncbigene:2770 | |
GNAS | GeneProduct | ensembl:ENSG00000087460 | Gs alpha subunit (also Gαs, Gsα) |
GNAI2 | GeneProduct | ensembl:ENSG00000114353 |
References
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- Evaluation of the binding of the A-1 selective adenosine radioligand, cyclopentyladenosine (CPA), to rat brain tissue. Williams M, Braunwalder A, Erickson TJ. Naunyn Schmiedebergs Arch Pharmacol. 1986 Feb;332(2):179–83. PubMed Europe PMC Scholia
- The non-xanthine heterocyclic compound SCH 58261 is a new potent and selective A2a adenosine receptor antagonist. Zocchi C, Ongini E, Conti A, Monopoli A, Negretti A, Baraldi PG, et al. J Pharmacol Exp Ther. 1996 Feb;276(2):398–404. PubMed Europe PMC Scholia
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- ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. Li Q, Ye K, Blad CC, den Dulk H, Brouwer J, Ijzerman AP, et al. J Pharmacol Exp Ther. 2007 Feb;320(2):637–45. PubMed Europe PMC Scholia
- Recent improvements in the development of A(2B) adenosine receptor agonists. Baraldi PG, Tabrizi MA, Fruttarolo F, Romagnoli R, Preti D. Purinergic Signal. 2008 Dec;4(4):287–303. PubMed Europe PMC Scholia
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- Action of MK-7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation. Richards D, Gever JR, Ford AP, Fountain SJ. Br J Pharmacol. 2019 Jul;176(13):2279–91. PubMed Europe PMC Scholia
- Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications. Marucci G, Dal Ben D, Buccioni M, Martí Navia A, Spinaci A, Volpini R, et al. Expert Opin Ther Pat. 2019 Dec;29(12):943–63. PubMed Europe PMC Scholia