Peroxiredoxin 2 induced ovarian failure (WP4873)
Homo sapiens
This pathway summarizes the influence of reactive oxygen species on ovarian aging, ovarian failure and therefore female infertility.
Authors
Bas Lahaije , Friederike Ehrhart , Egon Willighagen , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Annotations
Disease Ontology
infertility ovarian dysfunctionPathway Ontology
c-Jun N-terminal kinases MAPK signaling pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
Cytochrome C | Metabolite | chebi:18070 | SomaticMultiple homologues found: En:ENSG00000172115;En:ENSG00000172115; |
Reactive oxygen species | Metabolite | chebi:26523 | |
Estradiol-17beta | Metabolite | chebi:16469 | |
Progesterone | Metabolite | drugbank:DB00396 | |
BAX | GeneProduct | ensembl:ENSG00000087088 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003873 |
PARP2 | GeneProduct | ensembl:ENSG00000129484 | |
CYP11A1 | Protein | ensembl:ENSG00000140459 | MitochondrialHomology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9QZ82 |
HSD3B2 | Protein | ensembl:ENSG00000203859 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:E9PXG7 |
JNK | Protein | uniprot:P53779 | |
CASP3 | Protein | ensembl:ENSG00000164305 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:A0A1B0GRX1 |
STAR | Protein | ensembl:ENSG00000147465 | MitichondrialHomology Mapping from Mus musculus to Homo sapiens: Original ID = S:P51557 |
Peroxiredoxin-2 | Protein | uniprot:P32119 | No homologues found for original id S:Q61171 |
References
- Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice. Park SJ, Kim JH, Lee DG, Kim JM, Lee DS. Free Radic Biol Med. 2018 Aug 1;123:96–106. PubMed Europe PMC Scholia