IL18 signaling (WP4754)
Homo sapiens
Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines and was initially described as an IFN-γ-inducing factor derived from anti-CD3-stimulated Th1 cells. IL-18 plays a significant role in the activation of hematopoietic cell types mediating both Th1 and Th2 responses and is the primary inducer of interferon-γ in these cells. The biological activity of IL-18 is mediated through its binding to the IL-18 receptor complex (IL-18R) and activation of nuclear factor-kB (NF-kB), culminating in the production and release of several cytokines, chemokines, and cellular adhesion molecules. In certain cell types, IL-18 also activates mitogen-activated protein kinases (MAPKs) and PI3K/AKT signaling modules leading to the production and release of proinflammatory cytokines. IL-18 mediated signaling acts as one of the vital components of the immunomodulatory cytokine networks involved in host defense, inflammation, and tissue regeneration.
Authors
Yashwanth Subbannayya , Kristina Hanspers , Egon Willighagen , Rex D A B , and Eric WeitzActivity
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Cited In
- Machine learning and bioinformatics to identify 8 autophagy-related biomarkers and construct gene regulatory networks in dilated cardiomyopathy (2022).
- The Biological Interaction of SARS-CoV-2 Infection and Osteoporosis: A Preliminary Study (2022).
- Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition (2020).
- A comprehensive pathway map of IL-18-mediated signalling (2019).
- GediNET for discovering gene associations across diseases using knowledge based machine learning approach (2022).
- Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD) (2022).
- Gastric cancer actionable genomic alterations across diverse populations worldwide and pharmacogenomics strategies based on precision oncology (2024).
- In silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions (2023).
- Transcriptional Profiling of SARS-CoV-2-Infected Calu-3 Cells Reveals Immune-Related Signaling Pathways (2024).
- A Practical Strategy for Exploring the Pharmacological Mechanism of Luteolin Against COVID-19/Asthma Comorbidity: Findings of System Pharmacology and Bioinformatics Analysis (2024).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
oxidative phosphorylation pathway Interleukin mediated signaling pathway signaling pathway in the adaptive immune response interleukin-1 signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| CYCS | GeneProduct | ncbigene:54205 | |
| BAX | GeneProduct | ncbigene:581 | |
| MAPK1 | GeneProduct | ncbigene:5594 | |
| IL-18BP | GeneProduct | ncbiprotein:10068 | |
| CASP8 | GeneProduct | ncbigene:841 | |
| NOX1 | GeneProduct | ncbigene:27035 | |
| TICAM2 | GeneProduct | ncbigene:353376 | |
| SLC12A3 | GeneProduct | ncbigene:6559 | |
| LCK | GeneProduct | ncbigene:3932 | |
| NFKB1 | GeneProduct | ncbigene:4790 | |
| NCF1 | GeneProduct | ncbigene:653361 | |
| NCF2 | GeneProduct | ncbigene:4688 | |
| IMP3 | GeneProduct | ncbigene:55272 | |
| ELAVL1 | GeneProduct | ncbigene:1994 | |
| CTNNB1 | GeneProduct | ncbigene:1499 | |
| GSK3B | GeneProduct | ncbigene:2932 | |
| Protein | GeneProduct | ncbigene:11 | |
| AKT1 | GeneProduct | ncbiprotein:NP_005154.2 | |
| MAPK3 | GeneProduct | ncbigene:5595 | |
| CREB1 | GeneProduct | ncbiprotein:NP_604391.1 | |
| MAPK14 | GeneProduct | ncbiprotein:NP_001306.1 | |
| PIK3R1 | GeneProduct | ncbigene:5295 | |
| ELK1 | GeneProduct | ncbiprotein:NP_001107595.1 | |
| MAPK8 | GeneProduct | ncbiprotein:NP_620637.1 | |
| CHUK | GeneProduct | ncbigene:1147 | |
| IKBKB | GeneProduct | ncbigene:3551 | |
| RPS6 | GeneProduct | ncbiprotein:NP_001001.2 | |
| SRC | GeneProduct | ncbiprotein:NP_005408.1 | |
| NFKBIA | GeneProduct | ncbigene:4792 | |
| HSPB1 | GeneProduct | ncbigene:3315 | |
| CSN2 | GeneProduct | ncbigene:1447 | |
| MAP3K7 | GeneProduct | ncbigene:6885 | |
| GSK3A | GeneProduct | ncbiprotein:NP_002084.2 | |
| PTEN | GeneProduct | ncbigene:5728 | |
| ACACB | GeneProduct | ncbigene:32 | |
| JUN | GeneProduct | ncbiprotein:NP_002219.1 | |
| GRIN2B | GeneProduct | ncbigene:2904 | |
| PRKCA | GeneProduct | ncbigene:5578 | |
| PRKCB | GeneProduct | ncbigene:5579 | |
| RAF1 | GeneProduct | ncbiprotein:NP_001341618.1 | |
| TNFRSF1A | GeneProduct | ncbigene:7132 | |
| MEF2A | GeneProduct | ncbigene:4205 | |
| CEBPB | GeneProduct | ncbigene:1051 | |
| GATA1 | GeneProduct | ncbigene:2623 | |
| SP1 | GeneProduct | ncbigene:6667 | |
| CFLAR | GeneProduct | ncbigene:8837 | |
| BID | GeneProduct | ncbigene:637 | |
| CASP3 | GeneProduct | ncbigene:836 | |
| IRF1 | GeneProduct | ncbigene:3659 | |
| TNF | GeneProduct | ncbigene:7124 | |
| TP53 | GeneProduct | ncbigene:7157 | |
| FASLG | GeneProduct | ncbigene:356 | |
| FAS | GeneProduct | ncbigene:355 | |
| MAPK9 | GeneProduct | ncbigene:5601 | |
| NFATC4 | GeneProduct | ncbigene:4776 | |
| RELA | GeneProduct | ncbigene:5970 | |
| IRAK4 | GeneProduct | ncbigene:12682231 | |
| MAP2K7 | GeneProduct | ncbigene:5609 | |
| STAT3 | GeneProduct | ncbiprotein:NP_644805.1 | |
| AMPK1 | GeneProduct | ncbigene:5562 | |
| PARP1 | GeneProduct | ncbigene:142 | |
| RPS6KB1 | GeneProduct | ncbigene:6198 | |
| PRKCD | GeneProduct | ncbigene:5580 | |
| IRAK1 | Protein | ncbigene:3654 | |
| TRAF6 | Protein | ncbigene:7189 | |
| IL18RAP | Protein | ncbigene:8807 | IL18RAP |
| IL18 | Protein | ncbigene:3606 | |
| IL18R1 | Protein | ncbigene:8809 | |
| MYD88 | Protein | ncbigene:4615 | |
| IL37 | Protein | ncbigene:27178 |
References
- A comprehensive pathway map of IL-18-mediated signalling. Rex DAB, Agarwal N, Prasad TSK, Kandasamy RK, Subbannayya Y, Pinto SM. J Cell Commun Signal. 2020 Jun;14(2):257–66. PubMed Europe PMC Scholia