Sphingolipid metabolism overview (WP4725)

Homo sapiens

New PW, homology converted

Authors

Denise Slenter , Eric Weitz , Conroy lipids , and Aishwarya Iyer

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Inherited Metabolic Disorders (IMD) Pathways Lipids and LIPID MAPS

Annotations

Pathway Ontology

sphingolipid metabolic pathway sphingomyelin metabolic pathway sphingolipid biosynthetic pathway

Participants

Label Type Compact URI Comment
ATP Metabolite chebi:30616
3-keto-sphinganine Metabolite lipidmaps:LMSP01020002
Palmitoyl-CoA Metabolite lipidmaps:LMFA07050360 aka CoA(16:0)
Serine Metabolite pubchem.compound:5951
Hexadecanal Metabolite lipidmaps:LMFA06000088
Ethanolamine-phosphate Metabolite pubchem.compound:1015
H2O Metabolite chebi:15377
Sphingosine Metabolite lipidmaps:LMSP01010001
Sphinganine Metabolite lipidmaps:LMSP01020001
Sphinganine-1-phosphate Metabolite lipidmaps:LMSP01050002
DH-Ceramide Metabolite lipidmaps:LMSP02020000
Ceramide Metabolite lipidmaps:LMSP02010000
Cer-1-P Metabolite lipidmaps:LMSP02050000
DH-Cer-1-P Metabolite lipidmaps:LMSP020500A0
SM Metabolite lipidmaps:LMSP0301
Glc-Cer Metabolite lipidmaps:LMSP0501AA00
DH-SM Metabolite lipidmaps:LMSP030100A0
Gal-Cer Metabolite lipidmaps:LMSP0501AC00
Sphingosine-1-phosphate Metabolite lipidmaps:LMSP01050001
(2E)-hexadecenal Metabolite lipidmaps:LMFA06000089
CoA(16:0) Metabolite lipidmaps:LMFA07050360
CoA(18:0) Metabolite chebi:15541
CoA(20:0) Metabolite chebi:15527
CoA(22:0) Metabolite cas:24330-89-0
CoA(24:0) Metabolite cas:24305-30-4
CoA(24:1) Metabolite cas:88362-35-0
CoA(22:0) Metabolite cas:24330-89-0 AKA 'Coenzyme A, S-​docosanoate'
CoA(24:0) Metabolite cas:24305-30-4 AKA 'Coenzyme A, S-​(tetracosanoate)​'
CoA(24:1) Metabolite cas:88362-35-0 AKA 'Coenzyme A, S-​(15Z)​-​15-​tetracosenoate'
CoA(26:0) Metabolite cas:99313-57-2 AKA 'Coenzyme A, S-​hexacosanoate'
CoA(26:0) Metabolite cas:99313-57-2
ADP Metabolite chebi:456216
CERK GeneProduct uniprot:Q8TCT0 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:223753
SGPP1 GeneProduct uniprot:Q9BX95 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9JI99
ASAH1 GeneProduct uniprot:Q13510 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9WV54
SGMS1 GeneProduct uniprot:Q86VZ5 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208449
SPHK2 GeneProduct uniprot:Q9NRA0 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9JIA7
GBA1 GeneProduct uniprot:P04062
SPTLC1 GeneProduct uniprot:O15269 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:268656
SPHK1 GeneProduct uniprot:Q9NYA1 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8CI15
DEGS1 GeneProduct uniprot:O15121 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13244
SPTLC2 GeneProduct uniprot:O15270 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P97363
DEGS2 GeneProduct uniprot:Q6QHC5 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:70059
PLPP3 GeneProduct uniprot:O14495 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67916
SGPP2 GeneProduct uniprot:Q8IWX5 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q810K3
GBA2 GeneProduct uniprot:Q9HCG7
GBA3 GeneProduct uniprot:Q9H227
Ppap2a Protein ncbigene:8611 No homologues found for original id L:19012 Also, known as PLPP1
SGPL1 Protein ensembl:ENSG00000166224 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20397
UGCG Protein uniprot:Q16739 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22234
KDSR Protein uniprot:Q06136 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q6GV12
CERS4 Protein ensembl:ENSG00000090661 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67260
CERS6 Protein ensembl:ENSG00000172292 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:241447
SMPD1 Protein uniprot:P17405 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20597
SGMS2 Protein uniprot:Q8NHU3 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74442
Ppap2c Protein ncbigene:8612 Also known as PLPP2
UGT8 Protein ensembl:ENSG00000174607 EC:2.4.1.47
CERS1 Protein ensembl:ENSG00000223802 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P27545
CERS2 Protein ensembl:ENSG00000143418 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:76893
CERS3 Protein ensembl:ENSG00000154227 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q1A3B0

References

  1. Characterization of murine sphingosine-1-phosphate phosphohydrolase. Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S. J Biol Chem. 2002 Mar 15;277(11):8920–7. PubMed Europe PMC Scholia
  2. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. Merrill AH Jr. J Biol Chem. 2002 Jul 19;277(29):25843–6. PubMed Europe PMC Scholia
  3. Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities. Han G, Gupta SD, Gable K, Niranjanakumari S, Moitra P, Eichler F, et al. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8186–91. PubMed Europe PMC Scholia
  4. A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia