Sphingolipid metabolism overview (WP4725)

Homo sapiens

Authors

Denise Slenter , Eric Weitz , Conroy lipids , and Aishwarya Iyer

Activity

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Cited In

• Identification of the effects of COVID-19 on patients with pulmonary fibrosis and lung cancer: a bioinformatics analysis and literature review (2022).
• Tissue-specific pathway activities: A retrospective analysis in COVID-19 patients (2022).
• Reconstructed Human Skin with Hypodermis Shows Essential Role of Adipose Tissue in Skin Metabolism (2024).

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Organisms

Homo sapiens

Communities

Inherited Metabolic Disorders (IMD) Pathways Lipids and LIPID MAPS

Annotations

Pathway Ontology

sphingolipid metabolic pathway sphingomyelin metabolic pathway sphingolipid biosynthetic pathway

References

1. Characterization of murine sphingosine-1-phosphate phosphohydrolase. Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S. J Biol Chem. 2002 Mar 15;277(11):8920–7. PubMed Europe PMC Scholia
2. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. Merrill AH Jr. J Biol Chem. 2002 Jul 19;277(29):25843–6. PubMed Europe PMC Scholia
3. Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities. Han G, Gupta SD, Gable K, Niranjanakumari S, Moitra P, Eichler F, et al. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8186–91. PubMed Europe PMC Scholia
4. A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia