Eicosanoid metabolism via cytochrome P450 monooxygenases (WP4349)
Mus musculus
This pathway is inspired by the LIPID MAPS>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps] and extended with the bottom left side of Figure 1 from Dennis and Norris (2015 [https://www.ncbi.nlm.nih.gov/pubmed/26139350]). Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases(LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349]. This pathway visualises the third route, via CYP. Orange boxes represent peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.
Authors
Eoin Fahy , Ryan Miller , Denise Slenter , Egon Willighagen , and Eric WeitzActivity
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Organisms
Mus musculusCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology
eicosanoid metabolic pathway eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Arachidonic acid | Metabolite | lipidmaps:LMFA01030001 | |
| 16-HETE | Metabolite | lipidmaps:LMFA03090010 | |
| 17-HETE | Metabolite | lipidmaps:LMFA03060091 | |
| 18-HETE | Metabolite | lipidmaps:LMFA03060092 | |
| 19-HETE | Metabolite | lipidmaps:LMFA03060106 | |
| 20-HETE | Metabolite | lipidmaps:LMFA03060009 | |
| 5,6-EpETrE | Metabolite | lipidmaps:LMFA03080002 | |
| 8,9-EpETrE | Metabolite | lipidmaps:LMFA03080003 | |
| 11,12-EpETrE | Metabolite | lipidmaps:LMFA03090010 | |
| 14,15-EpETrE | Metabolite | lipidmaps:LMFA03080005 | |
| 5,6-DiHETrE | Metabolite | lipidmaps:LMFA03050004 | |
| 8,9-DiHETrE | Metabolite | lipidmaps:LMFA03050006 | |
| 11,12-DiHETrE | Metabolite | lipidmaps:LMFA03050008 | |
| 14,15-DiHETrE | Metabolite | lipidmaps:LMFA03050010 | |
| Ephx2 | GeneProduct | ncbigene:13850 | |
| Cyp4a10 | GeneProduct | ncbigene:13117 | |
| Cyp4a12a | GeneProduct | ncbigene:277753 | |
| Cyp4a12b | GeneProduct | ncbigene:13118 | |
| Cyp4f14 | GeneProduct | ncbigene:64385 | |
| Cyp4f18 | GeneProduct | ncbigene:72054 | |
| PPAR gamma | Protein | uniprot:P37238 | AKA Peroxisome proliferator-activated receptor gamma |
| Cyp2c29 | Protein | ncbigene:13095 | |
| Cyp2c37 | Protein | ncbigene:13096 | |
| Cyp2c38 | Protein | ncbigene:13097 | |
| Cyp2c39 | Protein | ncbigene:13098 | |
| Cyp2c40 | Protein | ncbigene:13099 | |
| Cyp2c44 | Protein | ncbigene:226143 | |
| Cyp2c54 | Protein | ncbigene:404195 | |
| Cyp2c55 | Protein | ncbigene:72082 | |
| Cyp2j5 | Protein | ncbigene:13109 | |
| PPAR alpha | Protein | uniprot:P23204 | AKA Peroxisome proliferator-activated receptor alpha |
References
- A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
- Eicosanoid storm in infection and inflammation. Dennis EA, Norris PC. Nat Rev Immunol. 2015 Aug;15(8):511–23. PubMed Europe PMC Scholia