Eicosanoid metabolism via lipoxygenases (LOX) (WP4348)
Mus musculus
This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps]. Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases(LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349]. This pathway visualises the second route, via LOX.
Authors
Eoin Fahy , Ryan Miller , Denise Slenter , Egon Willighagen , Eric Weitz , and Conroy lipidsActivity
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Cited In
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Organisms
Mus musculusCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology
eicosanoid metabolic pathway lipoxygenase mediated pathway of arachidonic acid metabolism| Label | Type | Compact URI | Comment |
|---|---|---|---|
| EXA4 | Metabolite | lipidmaps:LMFA03020037 | |
| LTA4 | Metabolite | lipidmaps:LMFA03020023 | |
| 5,6-Ep-15S-HETE | Metabolite | lipidmaps:LMFA03060075 | |
| 20-oxo-leukotriene B4 | Metabolite | lipidmaps:LMFA03020064 | |
| Arachidonic acid | Metabolite | lipidmaps:LMFA01030001 | |
| 15S-HpETE | Metabolite | lipidmaps:LMFA03060014 | |
| 15S-HETE | Metabolite | lipidmaps:LMFA03060001 | |
| 8-HpETE | Metabolite | lipidmaps:LMFA03060073 | |
| 8S-HETE | Metabolite | lipidmaps:LMFA03060006 | |
| 15-oxoETE | Metabolite | lipidmaps:LMFA03060051 | |
| LXA4 | Metabolite | lipidmaps:LMFA03040001 | |
| 12S-HpETE | Metabolite | lipidmaps:LMFA03060013 | |
| 12S-HETE | Metabolite | lipidmaps:LMFA03060007 | |
| 12-oxoETE | Metabolite | lipidmaps:LMFA03060019 | |
| HXB3 | Metabolite | lipidmaps:LMFA03090003 | |
| HXA3 | Metabolite | lipidmaps:LMFA03090005 | |
| Trioxilin A3 | Metabolite | lipidmaps:LMFA03090002 | |
| Trioxilin B3 | Metabolite | lipidmaps:LMFA03090004 | |
| LXB4 | Metabolite | lipidmaps:LMFA03040002 | |
| LTB4 | Metabolite | lipidmaps:LMFA03020001 | |
| 12-epi-LTB4 | Metabolite | lipidmaps:LMFA03020015 | |
| 6-trans-12-epi-delta-LTB4 | Metabolite | lipidmaps:LMFA03020014 | |
| 6-trans-delta-LTB4 | Metabolite | lipidmaps:LMFA03020013 | |
| LTC4 | Metabolite | lipidmaps:LMFA03020003 | |
| LTD4 | Metabolite | lipidmaps:LMFA03020006 | |
| LTE4 | Metabolite | lipidmaps:LMFA03020002 | |
| EXC4 | Metabolite | lipidmaps:LMFA03020031 | |
| EXD4 | Metabolite | lipidmaps:LMFA03020032 | |
| EXE4 | Metabolite | lipidmaps:LMFA03020033 | |
| 20-hydroxy-LTB4 | Metabolite | lipidmaps:LMFA03020018 | |
| 20-carboxy-LTB4 | Metabolite | lipidmaps:LMFA03020016 | |
| 18-carboxy-dinor-LTB4 | Metabolite | lipidmaps:LMFA01170145 | |
| 11-trans-LTC4 | Metabolite | lipidmaps:LMFA03020020 | |
| 11-trans-LTD4 | Metabolite | lipidmaps:LMFA03020021 | |
| 11-trans-LTE4 | Metabolite | lipidmaps:LMFA03020022 | |
| 5S-HpETE | Metabolite | lipidmaps:LMFA03060012 | |
| 5S-HETE | Metabolite | lipidmaps:LMFA03060084 | |
| 5-oxoETE | Metabolite | lipidmaps:LMFA03060011 | |
| 15-oxo-LXA4 | Metabolite | lipidmaps:LMFA03040009 | |
| 13,14-dihydro-15-oxo-LXA4 | Metabolite | lipidmaps:LMFA03040008 | |
| 12-oxo-LTB4 | Metabolite | lipidmaps:LMFA03020024 | |
| Cyp4a10 | GeneProduct | uniprot:O88833 | |
| Lta4h | GeneProduct | uniprot:P24527 | |
| Mgst2 | GeneProduct | uniprot:A2RST1 | |
| Gpx4 | GeneProduct | uniprot:O70325 | |
| Cyp4f3 | GeneProduct | uniprot:Q99N16 | |
| Gpx1 | GeneProduct | uniprot:P11352 | |
| Alox5 | GeneProduct | uniprot:P48999 | |
| Mgst3 | GeneProduct | uniprot:Q9CPU4 | |
| Alox15 | GeneProduct | ncbigene:11687 | |
| Hpgd | GeneProduct | uniprot:Q8VCC1 | |
| Ephx2 | GeneProduct | uniprot:P34914 | |
| Ltc4s | GeneProduct | uniprot:Q60860 | |
| Cyp4a12a | GeneProduct | uniprot:Q91WL5 | |
| Cyp4a12b | GeneProduct | uniprot:A2A974 | |
| Cyp4f14 | GeneProduct | uniprot:Q9EP75 | |
| Cyp4f18 | GeneProduct | uniprot:Q99N16 | |
| Acox1 | GeneProduct | uniprot:Q9R0H0 | |
| Acox2 | GeneProduct | uniprot:Q9QXD1 | |
| Acox3 | GeneProduct | uniprot:Q3TAW3 | |
| Ehhadh | GeneProduct | uniprot:Q9DBM2 | |
| Acaa1a | GeneProduct | uniprot:Q921H8 | |
| Ggt1 | GeneProduct | uniprot:Q60928 | |
| Ggt5 | GeneProduct | uniprot:Q9Z2A9 | |
| Dpep1 | GeneProduct | uniprot:P31428 | |
| Dpep2 | GeneProduct | uniprot:Q8C255 | |
| Alox12 | GeneProduct | ncbigene:11684 | |
| Ptgr1 | GeneProduct | uniprot:Q91YR9 | AKA Ltb4dh |
| Ptgr2 | GeneProduct | uniprot:Q8VDQ1 | AKA Zadh1 |
References
- Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product. Lee TH, Menica-Huerta JM, Shih C, Corey EJ, Lewis RA, Austen KF. J Biol Chem. 1984 Feb 25;259(4):2383–9. PubMed Europe PMC Scholia
- Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology. Buczynski MW, Dumlao DS, Dennis EA. J Lipid Res. 2009 Jun;50(6):1015–38. PubMed Europe PMC Scholia