Mitochondrial fission and fusion (WP4318)

Homo sapiens

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"The localization, as well as some interaction and modification of the principal proteins involved in the two processes are shown. Once dephosphorylated, DRP1 is recruited to the outer membrane by FIS1 or by another, unknown, component. The oligomerization of DRP1 is followed by constriction of the membrane and mitochondrial fission. The pro-fusion proteins (MFNs on the outer membrane and OPA1 on the inner membrane) oligomerize to induce fusion of the membranes. Other additional components of the machinery are shown." [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933866/ Silvia Campello and Luca Scorrano 2010]; diagram derived from Figure 1.

Authors

Amadeo , Kristina Hanspers , Susan Coort , Aishwarya Iyer , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

mitochondria fusion pathway mitochondria fission pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
MIB1 GeneProduct ensembl:ENSG00000101752
MFN1 GeneProduct ensembl:ENSG00000171109
FIS1 GeneProduct ensembl:ENSG00000214253
MFN2 GeneProduct ensembl:ENSG00000116688
OPA1 GeneProduct ensembl:ENSG00000198836
BNIP3 GeneProduct ensembl:ENSG00000176171
DRP1 GeneProduct ensembl:ENSG00000087470
BAX GeneProduct ensembl:ENSG00000087088
BCL2 GeneProduct ensembl:ENSG00000171552
Endophilin-A1 GeneProduct ensembl:ENSG00000107295
PLD1 GeneProduct ensembl:ENSG00000075651
MTP18 GeneProduct ensembl:ENSG00000242114
Prohibitin Protein uniprot:A8K401

References

  1. Mitochondrial shape changes: orchestrating cell pathophysiology. Campello S, Scorrano L. EMBO Rep. 2010 Sep;11(9):678–84. PubMed Europe PMC Scholia