Extracellular vesicles in the crosstalk of cardiac cells (WP4300)
Homo sapiens
(A) FB-derived exosomes enriched with miR-21-3p or Spp1 and EGFR proteins are transferred to CMs, leading to CM hypertrophy. (B) EVs secreted from CMs or MSCs, as well as circulating EVs exert regulatory effects on CM apoptosis. (C) CM-derived exosomal HSP90 together with secreted IL-6 are able to activate STAT-3 signaling in cardiac FBs, leading to cardiac fibrosis; whereas CM-derived exosomes from exercised diabetic mice express high levels of miR-29b and miR-455, thus reducing cardiac fibrosis. (D) EVs secreted from CMs or MSCs are transferred to ECs, exerting pro- or anti-angiogenic activities. Description from Bei et al.
Authors
Kristina Hanspers , Anders Riutta , Egon Willighagen , and Martina Summer-KutmonActivity
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Cited In
- Network-based identification genetic effect of SARS-CoV-2 infections to Idiopathic pulmonary fibrosis (IPF) patients (2020).
- Identification of the Genetic Influence of SARS-CoV-2 Infections on IgA Nephropathy Based on Bioinformatics Method (2023).
- In silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions (2023).
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Organisms
Homo sapiensCommunities
ExRNAAnnotations
Cell Type Ontology
fibroblast of cardiac tissue cardiac endothelial cell cardiac muscle cellPathway Ontology
regulatory pathwayReferences
- Extracellular Vesicles in Cardiovascular Theranostics. Bei Y, Das S, Rodosthenous RS, Holvoet P, Vanhaverbeke M, Monteiro MC, et al. Theranostics. 2017 Sep 26;7(17):4168–82. PubMed Europe PMC Scholia