Ethanol metabolism resulting in production of ROS by CYP2E1 (WP4268)
Rattus norvegicus
Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes.
Authors
Ado , Marvin Martens , Friederike Ehrhart , and Egon WillighagenActivity
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Organisms
Rattus norvegicusCommunities
Annotations
Pathway Ontology
| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Staurosporine | Metabolite | chebi:57491 | |
| Fluoride | Metabolite | chebi:17051 | |
| Enflurane | Metabolite | hmdb:HMDB0014373 | |
| acetaldehyde | Metabolite | chebi:15343 | |
| Ethanol | Metabolite | chebi:16236 | |
| Halothane | Metabolite | chebi:5615 | |
| Vitamin C | Metabolite | chebi:38290 | |
| Diallyl sulfide | Metabolite | chebi:4489 | |
| Sevoflurane | Metabolite | chebi:9130 | |
| 6-Hydroxychlorzoxazone | Metabolite | hmdb:HMDB0060998 | |
| Isoflurane | Metabolite | chebi:6015 | |
| NAPQI | Metabolite | chebi:29132 | |
| Methoxyflurane | Metabolite | chebi:6843 | |
| Acetaminophen | Metabolite | chebi:46195 | |
| Chlorzoxazone | Metabolite | chebi:3655 | |
| U0126 | Metabolite | chebi:90693 | |
| Trifluoroacetic acid | Metabolite | chebi:45892 | |
| Mapk8 | GeneProduct | ensembl:ENSRNOG00000020155 | |
| Cyp2e1 | GeneProduct | ensembl:ENSRNOG00000012458 | |
| Sp1 | GeneProduct | ensembl:ENSRNOG00000014084 | |
| Map2k2 | GeneProduct | ensembl:ENSRNOG00000020005 | |
| Maff | GeneProduct | ensembl:ENSRNOG00000012886 | |
| Mafg | GeneProduct | ensembl:ENSRNOG00000036697 | |
| Map2k1 | GeneProduct | ensembl:ENSRNOG00000010176 | |
| Mafk | GeneProduct | ensembl:ENSRNOG00000001277 | |
| Nfe2l2 | GeneProduct | ensembl:ENSRNOG00000001548 | |
| Protein kinase C | Protein | uniprot:A0A0G2K5Q0 |
References
- Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Jin M, Ande A, Kumar A, Kumar S. Cell Death Dis. 2013 Mar 21;4(3):e554. PubMed Europe PMC Scholia