Transcriptional cascade regulating adipogenesis (WP4211)
Homo sapiens
Peroxisome proliferator-activated receptor gamma (PPARG) lies at the core of the transcriptional cascade that regulates adipogenesis. The expression of PPARG is regulated by several pro-adipogenic (green) and anti-adipogenic (orange) factors. PPARG itself is activated by an as-yet-uncharacterized ligand. CCAAT-enhancer-binding protein alpha (C/EBPA) is regulated through a series of inhibitory protein–protein interactions. Some transcription-factor families have several members that participate in adipogenesis, such as the Krüppel-like factors (KLFs). Rosen et al. Figure 2a
Authors
Martina Summer-Kutmon and Alex PicoActivity
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Cited In
- In silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions (2023).
- Transcriptional Profiling of SARS-CoV-2-Infected Calu-3 Cells Reveals Immune-Related Signaling Pathways (2024).
- The differential expression of adipose tissue genes in short, medium and long-term periods after bariatric surgery (2024).
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Organisms
Homo sapiensCommunities
Annotations
Cell Type Ontology
fat cellPathway Ontology
signaling pathway pertinent to development| Label | Type | Compact URI | Comment |
|---|---|---|---|
| GATA2 | GeneProduct | ensembl:ENSG00000179348 | GATA2/3 |
| GATA3 | GeneProduct | ensembl:ENSG00000107485 | GATA2/3 |
| CEBPA | GeneProduct | ensembl:ENSG00000245848 | C/EBPα |
| CEBPG | GeneProduct | ensembl:ENSG00000153879 | C/EBPγ |
| KLF5 | GeneProduct | ensembl:ENSG00000102554 | |
| SREBF1 | GeneProduct | ensembl:ENSG00000072310 | SREBP1c |
| CEBPD | GeneProduct | ensembl:ENSG00000221869 | C/EBPδ |
| CEBPB | GeneProduct | ensembl:ENSG00000172216 | C/EBPβ |
| PPARG | GeneProduct | ensembl:ENSG00000132170 | PPARγ |
| KLF2 | GeneProduct | ensembl:ENSG00000127528 | |
| EGR2 | GeneProduct | ensembl:ENSG00000122877 | KROX20 |
| DDIT3 | GeneProduct | ensembl:ENSG00000175197 | CHOP |
| KLF15 | GeneProduct | ensembl:ENSG00000163884 |
References
- Adipocyte differentiation from the inside out. Rosen ED, MacDougald OA. Nat Rev Mol Cell Biol. 2006 Dec;7(12):885–96. PubMed Europe PMC Scholia