Immune response to tuberculosis (WP4197)
Homo sapiens
This pathway diagram is derived from Figure 6c in "The human immune response to tuberculosis and its treatment: a view from the blood" (PMID: 25703554, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368415 PMC4368415]). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP4197 CPTAC Assay Portal].
Authors
Andra Waagmeester , Egon Willighagen , Kristina Hanspers , and Eric WeitzActivity
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Cited In
- A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection (2020).
- Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma (2022).
- Discovering common pathogenetic processes between COVID-19 and tuberculosis by bioinformatics and system biology approach (2023).
- Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19 (2022).
- Longitudinal Neuropathological Consequences of Extracranial Radiation Therapy in Mice (2024).
- Statistical and network analyses reveal mechanisms for the enhancement of macrophage immunity by manganese in Mycobacterium tuberculosis infection (2024).
- Transcriptional Profiling of SARS-CoV-2-Infected Calu-3 Cells Reveals Immune-Related Signaling Pathways (2024).
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Organisms
Homo sapiensCommunities
Annotations
Disease Ontology
tuberculosisPathway Ontology
immune response pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| IRF9 | GeneProduct | ensembl:ENSG00000213928 | |
| PSMB8 | GeneProduct | ensembl:ENSG00000204264 | |
| OAS1 | GeneProduct | ensembl:ENSG00000089127 | |
| MX1 | GeneProduct | ensembl:ENSG00000157601 | |
| IRF1 | GeneProduct | ensembl:ENSG00000125347 | |
| SOCS1 | GeneProduct | ensembl:ENSG00000185338 | |
| STAT1 | GeneProduct | ensembl:ENSG00000115415 | |
| PIAS1 | GeneProduct | ensembl:ENSG00000033800 | |
| IFITM1 | GeneProduct | ensembl:ENSG00000185885 | |
| IFNGR1 | GeneProduct | ensembl:ENSG00000027697 | |
| PTPN2 | GeneProduct | ensembl:ENSG00000175354 | |
| TAP1 | GeneProduct | ensembl:ENSG00000168394 | |
| IFI35 | GeneProduct | ensembl:ENSG00000068079 | |
| IFIT1 | GeneProduct | ensembl:ENSG00000185745 | |
| TYK2 | GeneProduct | ensembl:ENSG00000105397 | |
| JAK1 | GeneProduct | ensembl:ENSG00000162434 | |
| IFIT3 | GeneProduct | ensembl:ENSG00000119917 | |
| STAT2 | GeneProduct | ensembl:ENSG00000170581 | |
| JAK2 | GeneProduct | ensembl:ENSG00000096968 | |
| IFNGR2 | GeneProduct | ensembl:ENSG00000159128 | |
| IFNAR1 | GeneProduct | ensembl:ENSG00000142166 | |
| IFNAR2 | GeneProduct | ensembl:ENSG00000159110 |
References
- An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Berry MPR, Graham CM, McNab FW, Xu Z, Bloch SAA, Oni T, et al. Nature. 2010 Aug 19;466(7309):973–7. PubMed Europe PMC Scholia
- Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response. Cliff JM, Lee JS, Constantinou N, Cho JE, Clark TG, Ronacher K, et al. J Infect Dis. 2013 Jan 1;207(1):18–29. PubMed Europe PMC Scholia
- Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers. Bloom CI, Graham CM, Berry MPR, Rozakeas F, Redford PS, Wang Y, et al. PLoS One. 2013 Aug 5;8(8):e70630. PubMed Europe PMC Scholia
- The human immune response to tuberculosis and its treatment: a view from the blood. Cliff JM, Kaufmann SHE, McShane H, van Helden P, O’Garra A. Immunol Rev. 2015 Mar;264(1):88–102. PubMed Europe PMC Scholia