Serotonin and anxiety (WP3947)

Homo sapiens

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Benekareddy et al observed the phenomenon that rats who were maternally separated show increased levels of induced anxiety-related behaviour during adulthood. Type 2 serotonin receptors have been implicated in anxiety related behaviour and may be suitable targets for reducing anxiety response. Benekareddy et al report that treatment with ketanserin (a serotonergic antagonist) during postnatal life blocked the long-lasting effects of maternal separation on anxiety behavior in the open field test and the elevated plus maze. Immediate Early Genes such as Arc have been found to be significantly affected in expression (Benekareddy et al). The downstream and upstream gene products of Arc were partly elucidated and presented in a pathway. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3947 CPTAC Assay Portal]

Authors

Kristina Hanspers and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

calcium/calmodulin dependent kinase signaling pathway altered calcineurin signaling pathway calcium/calmodulin dependent kinase 1 signaling pathway serotonin signaling pathway

Disease Ontology

anxiety disorder anxiety disorder

Cell Type Ontology

serotonergic neuron

Participants
Query Drugst.One

Label Type Compact URI Comment
THDOC Metabolite pubchem.compound:91475
Ketanserin Metabolite pubchem.compound:3822
Ca2+ Metabolite chebi:29108
DOC Metabolite pubchem.compound:6166
PLCD4 GeneProduct ensembl:ENSG00000115556 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026173
PLEK GeneProduct ensembl:ENSG00000115956 pleckstrin
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020120
POMC GeneProduct ensembl:ENSG00000115138 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020660
GRM1 GeneProduct ensembl:ENSG00000152822 G-protein-coupled phosphatidylinositol-calcium second messenger system
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000019828
TRPV1 GeneProduct ensembl:ENSG00000196689 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000005952
PRKCB GeneProduct ensembl:ENSG00000166501 Protein kinase C
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000052889
CAMK2B GeneProduct ensembl:ENSG00000058404 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000057897
FMR1 GeneProduct ensembl:ENSG00000102081 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000838
EEF2K GeneProduct ensembl:ENSG00000103319 'eEF2K' originally
CRH GeneProduct ensembl:ENSG00000147571 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000049796
PPP3CA GeneProduct ensembl:ENSG00000138814 calcineurin
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028161
GABRA1 GeneProduct ensembl:ENSG00000022355 GABA a receptor
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000010803
EEF2K GeneProduct ensembl:ENSG00000103319 Phosphorylates eEF2. 'eEF2K' originally
ARC GeneProduct ensembl:ENSG00000198576 Calcium ion channel
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022602
HTR2C GeneProduct ensembl:ENSG00000147246 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000041380
FOS GeneProduct ensembl:ENSG00000170345 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021250
HTR1A GeneProduct ensembl:ENSG00000178394 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021721
ADRA1A GeneProduct ensembl:ENSG00000120907 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000045875
ARC GeneProduct ensembl:ENSG00000198576 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022602
HTR2A GeneProduct ensembl:ENSG00000102468 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034997

References

  1. The alpha-adrenergic receptor blocking effect of ketanserin and the interaction between alpha-adrenergic and S2-serotonergic receptor blockade. van der Starre PJ, Reneman RS. J Cardiovasc Pharmacol. 1988;11 Suppl 1:S54-61. PubMed Europe PMC Scholia
  2. ARC channels: a novel pathway for receptor-activated calcium entry. Shuttleworth TJ, Thompson JL, Mignen O. Physiology (Bethesda). 2004 Dec;19:355–61. PubMed Europe PMC Scholia
  3. Physiological role of adrenal deoxycorticosterone-derived neuroactive steroids in stress-sensitive conditions. Reddy DS. Neuroscience. 2006;138(3):911–20. PubMed Europe PMC Scholia
  4. The immediate early gene arc/arg3.1: regulation, mechanisms, and function. Bramham CR, Worley PF, Moore MJ, Guzowski JF. J Neurosci. 2008 Nov 12;28(46):11760–7. PubMed Europe PMC Scholia
  5. Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress. Benekareddy M, Vadodaria KC, Nair AR, Vaidya VA. Biol Psychiatry. 2011 Dec 1;70(11):1024–32. PubMed Europe PMC Scholia
  6. Calcineurin is required for TRPV1-induced long-term depression of hippocampal interneurons. Jensen T, Edwards JG. Neurosci Lett. 2012 Feb 29;510(2):82–7. PubMed Europe PMC Scholia