Serotonin and anxiety-related events (WP3944)

Homo sapiens

Stress and anxiety disorders are risk factors for depression and these behaviours are modulated by corticotropin releasing factor (CRFR1) and serotonin (5-HT2R) receptors. (Source: Berg et al "5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms"). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3944 CPTAC Assay Portal]

Authors

Kristina Hanspers , Egon Willighagen , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway disease pathway

Cell Type Ontology

cerebral cortex neuron

Disease Ontology

anxiety disorder

Participants

Label Type Compact URI Comment
Serotonin Metabolite hmdb:HMDB0000259
Ketanserin Metabolite chebi:6123
HTR2A GeneProduct ensembl:ENSG00000102468 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034997
ARC GeneProduct ensembl:ENSG00000198576 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022602
HTR2C GeneProduct ensembl:ENSG00000147246 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000041380
HTR1A GeneProduct ensembl:ENSG00000178394 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021721
FOS GeneProduct ensembl:ENSG00000170345 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021250
PLEK GeneProduct ensembl:ENSG00000115956 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020120
PPP3CA GeneProduct ensembl:ENSG00000138814 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:107164
PRKCB GeneProduct ensembl:ENSG00000166501 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000052889
PLCD4 GeneProduct ensembl:ENSG00000115556 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026173
GRIN2D GeneProduct ensembl:ENSG00000105464 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002771
NLGN1 GeneProduct ensembl:ENSG00000169760 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000063887
CRHR1 GeneProduct ensembl:ENSG00000120088 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018634
CRH Protein ensembl:ENSG00000147571 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8CIT0

References

  1. 5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms. Berg KA, Clarke WP, Chen Y, Ebersole BJ, McKay RD, Maayani S. Mol Pharmacol. 1994 May;45(5):826–36. PubMed Europe PMC Scholia
  2. CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Magalhaes AC, Holmes KD, Dale LB, Comps-Agrar L, Lee D, Yadav PN, et al. Nat Neurosci. 2010 May;13(5):622–9. PubMed Europe PMC Scholia
  3. Enhanced function of prefrontal serotonin 5-HT(2) receptors in a rat model of psychiatric vulnerability. Benekareddy M, Goodfellow NM, Lambe EK, Vaidya VA. J Neurosci. 2010 Sep 8;30(36):12138–50. PubMed Europe PMC Scholia