Development and heterogeneity of the ILC family (WP3893)

Homo sapiens

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Development and heterogeneity of the innate lymphoid cell (ILC) family. ILCs develop from distinct progenitors in the fetal liver or bone marrow and then develop into mature ILCs in the periphery. Different transcription factors and cytokines are involved in the development of the three groups of mature ILCs. All ILCs develop from CLPs, which can differentiate into NKps or CHILPs. CHILPs can further differentiate into LTi cells through α4β7+ populations or into other ILC populations through differentiation into ILCps. ILC1s express T-bet, are responsive to IL-12, and produce IFN-γ and/or TNF. ILC2s highly express GATA3, are responsive to IL-25, IL-33 and TSLP, and produce IL-4, IL-5, IL-9, IL-13 and amphiregulin. ILC3s express ROR-γt, are responsive to IL-1β and IL-23, and produce IL-17 and/or IL-22. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3893 CPTAC Assay Portal]

Authors

Kristina Hanspers , Eric Weitz , and Martina Summer-Kutmon

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

regulatory pathway

Cell Type Ontology

pro-NK cell innate lymphoid cell natural killer cell common lymphoid progenitor

Participants
Query Drugst.One

Label Type Compact URI Comment
IL15 GeneProduct ensembl:ENSG00000164136
IL12A GeneProduct ensembl:ENSG00000168811
ID2 GeneProduct ensembl:ENSG00000115738
GATA3 GeneProduct ensembl:ENSG00000107485
TNF GeneProduct ensembl:ENSG00000232810
IL1B GeneProduct ensembl:ENSG00000125538
T-bet GeneProduct ensembl:ENSG00000073861
AHR GeneProduct ensembl:ENSG00000106546
IFNG GeneProduct ensembl:ENSG00000111537
IL6 GeneProduct ensembl:ENSG00000136244
IL7 GeneProduct ensembl:ENSG00000104432
BCL11B GeneProduct ensembl:ENSG00000127152
GFI1 GeneProduct ensembl:ENSG00000162676
TCF1 GeneProduct ensembl:ENSG00000135100
NFIL3 GeneProduct ensembl:ENSG00000165030
IL13 GeneProduct ensembl:ENSG00000169194
IL4 GeneProduct ensembl:ENSG00000113520
PLZF GeneProduct ensembl:ENSG00000109906
IL17A GeneProduct ensembl:ENSG00000112115
IL18 GeneProduct ensembl:ENSG00000150782
TOX GeneProduct ensembl:ENSG00000198846
IL25 GeneProduct ensembl:ENSG00000166090
IL23A GeneProduct ensembl:ENSG00000110944
IL22 GeneProduct ensembl:ENSG00000127318
AREG GeneProduct ensembl:ENSG00000109321
EOMES GeneProduct ensembl:ENSG00000163508
RORA GeneProduct ensembl:ENSG00000069667
IL33 GeneProduct ensembl:ENSG00000137033
TSLP GeneProduct ensembl:ENSG00000145777
IL5 GeneProduct ensembl:ENSG00000113525
IL9 GeneProduct ensembl:ENSG00000145839
IL-7 GeneProduct ensembl:ENSG00000104432
IL12B GeneProduct ensembl:ENSG00000113302

References

  1. The origin and role of innate lymphoid cells in the lung. Lai DM, Shu Q, Fan J. Mil Med Res. 2016 Aug 19;3:25. PubMed Europe PMC Scholia