MAPK and NFkB signaling inhibited by Yersinia YopJ (WP3849)

Homo sapiens

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This pathway is based on the figure 24.1 of "In Vitro Signaling by MAPK and NFκB Pathways Inhibited by Yersinia YopJ" (see bibliography). In the MAPK and NFkB pathways, YopJ is the main inhibitor of Raf and TRAF6, NIK, or MEKK1. YopJ, in the NFkB pathway, may inhibit TRAF6,NIK, or MEKK. The pathway is activated by the stimulus of the genes TRAF6, NIK, or MEKK1, or the stimulus on the interactions between Ras to Raf. In the NFkB pathway along with the MAPK pathway, with the use of activators such as kinases, G-proteins, and E3 ligases, are catalysts to initiate of signaling cascades with a concentrated lysate. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3849 CPTAC Assay Portal]

Authors

AAR&Co , Martina Summer-Kutmon , Kristina Hanspers , Egon Willighagen , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

mitogen activated protein kinase signaling pathway

Disease Ontology

bubonic plague

Participants
Query Drugst.One

Label Type Compact URI Comment
NIK GeneProduct uniprot:Q99558
MEKK1 GeneProduct uniprot:Q13233
MAPK GeneProduct ensembl:ENSG00000100030 MAPK not specified
IKBKG GeneProduct ensembl:ENSG00000269335
IKBKB GeneProduct ensembl:ENSG00000104365
IkB GeneProduct uniprot:P25963 IkB Not Specified
TRAF6 GeneProduct ensembl:ENSG00000175104
CHUK GeneProduct ensembl:ENSG00000213341
RAF GeneProduct ensembl:ENSG00000132155
NFKB GeneProduct ensembl:ENSG00000109320 NFKB Not Specified
Ras GeneProduct ensembl:ENSG00000126458
MKK GeneProduct uniprot:P52564 MKK Not Specified

References

  1. In vitro signaling by MAPK and NFkappaB pathways inhibited by Yersinia YopJ. Mukherjee S, Orth K. Methods Enzymol. 2008;438:343–53. PubMed Europe PMC Scholia