Physico-chemical features and toxicity-associated pathways (WP3680)

Homo sapiens

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This pathway is based on Figure 8 of "Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome."(See bibliography). These 3 pathways demonstrate close links between pathways associated with chemical hits and pathways associated with toxicity. The pathways associated with chemical hits (Wnt signaling, long-term depression, and ErbB signaling pathways) and the pathways associated with toxicity (focal adhesion, ALS, and pancreatic Cancer respectively) have been shown to have possible links through shared genes between the two pathways. The mechanisms of action presented by these links were only implied by the toxicity pathways. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3680 CPTAC Assay Portal]

Authors

AAR&Co , Kristina Hanspers , Egon Willighagen , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

pancreatic cancer

Pathway Ontology

amyotrophic lateral sclerosis pathway signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
O2 Metabolite chebi:15379
Ca2+ Metabolite chebi:29108
Peroxynitrite Metabolite hmdb:HMDB0002179
NO Metabolite chebi:16480
Arginine Metabolite hmdb:HMDB0000517
Glutamate Metabolite hmdb:HMDB0060475
ROS Metabolite hmdb:HMDB0003125
OH Metabolite chebi:16234
H20 Metabolite chebi:15377
CBL GeneProduct ensembl:ENSG00000110395
FZD1 GeneProduct ensembl:ENSG00000157240
ACTA1 GeneProduct ensembl:ENSG00000143632
PLCG GeneProduct ensembl:ENSG00000124181
CAMK GeneProduct ensembl:ENSG00000134072
ARP3 GeneProduct ensembl:ENSG00000115091
GRB2 GeneProduct ensembl:ENSG00000177885
STAT5 GeneProduct ensembl:ENSG00000126561
SOS1 GeneProduct ensembl:ENSG00000115904
DVL1 GeneProduct ensembl:ENSG00000107404
ELK GeneProduct ensembl:ENSG00000126767
MLCP GeneProduct ensembl:ENSG00000228868 myosin-light chain phosphatase
CTNNB1 GeneProduct ensembl:ENSG00000168036
ROCK2 GeneProduct ensembl:ENSG00000134318
Shc1 GeneProduct ensembl:ENSG00000160691
PP2A GeneProduct ensembl:ENSG00000113575
MYC GeneProduct ensembl:ENSG00000136997
JUN GeneProduct ensembl:ENSG00000177606
WNT16 GeneProduct ensembl:ENSG00000002745
NEFH GeneProduct ensembl:ENSG00000100285
NEFM GeneProduct ensembl:ENSG00000104722
PKB/AKT GeneProduct ensembl:ENSG00000142208
AXIN1 GeneProduct ensembl:ENSG00000103126
Raf GeneProduct ensembl:ENSG00000132155
PAK GeneProduct ensembl:ENSG00000149269
PI3K GeneProduct ensembl:ENSG00000105851
MEK GeneProduct ensembl:ENSG00000169032
SOD1 GeneProduct ensembl:ENSG00000142168
NEFL GeneProduct ensembl:ENSG00000277586
FAK GeneProduct ensembl:ENSG00000169398 PRK2
Focal adhesion kinase
GSK3B GeneProduct ensembl:ENSG00000082701
FN1 GeneProduct ensembl:ENSG00000115414
Ras GeneProduct ensembl:ENSG00000132155
DAAM1 GeneProduct ensembl:ENSG00000100592 assists in formation of Dvl-Rho complex
JNK GeneProduct ensembl:ENSG00000107643
NCK GeneProduct ensembl:ENSG00000158092
RHOA GeneProduct ensembl:ENSG00000067560
GluR GeneProduct uniprot:P42261 General glutamate receptor
ARP2 GeneProduct ensembl:ENSG00000138071
p21 GeneProduct ensembl:ENSG00000124762
GPX1 GeneProduct ensembl:ENSG00000233276
NOS1 GeneProduct ensembl:ENSG00000089250
MLC GeneProduct ensembl:ENSG00000168530
MAPK/ERK GeneProduct ensembl:ENSG00000100030
JNKK GeneProduct ensembl:ENSG00000065559
TGFA GeneProduct ensembl:ENSG00000163235
WNT11 GeneProduct ensembl:ENSG00000085741
PFN1 GeneProduct ensembl:ENSG00000108518
TMSB4 GeneProduct uniprot:P62328
p27 GeneProduct ensembl:ENSG00000111276
Src GeneProduct ensembl:ENSG00000197122
MLCK GeneProduct ensembl:ENSG00000065534 myosin light chain kinase
FZD2 GeneProduct ensembl:ENSG00000180340
FZD3 GeneProduct ensembl:ENSG00000104290
FZD4 GeneProduct ensembl:ENSG00000174804
FZD5 GeneProduct ensembl:ENSG00000163251
FZD6 GeneProduct ensembl:ENSG00000164930
FZD7 GeneProduct ensembl:ENSG00000155760
FZD8 GeneProduct ensembl:ENSG00000177283
FZD9 GeneProduct ensembl:ENSG00000188763
FZD10 GeneProduct ensembl:ENSG00000111432
APC GeneProduct ensembl:ENSG00000134982
PFN2 GeneProduct ensembl:ENSG00000070087
PFN3 GeneProduct ensembl:ENSG00000196570
PFN4 GeneProduct ensembl:ENSG00000176732
ErbB-1 GeneProduct ensembl:ENSG00000146648
ErbB-2 GeneProduct ensembl:ENSG00000141736
ErbB-4 GeneProduct ensembl:ENSG00000178568

References

  1. Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome. Antczak P, Ortega F, Chipman JK, Falciani F. PLoS One. 2010 Aug 27;5(8):e12385. PubMed Europe PMC Scholia