Insulin signaling in adipocytes (normal condition) (WP3634)
Homo sapiens
The paper (1) describes insulin signalling in human adipocytes under normal and diabetic states using mathematical models based on experimental data. This model corresponds to insulin signalling under normal conditions. Insulin signalling under diabetic condition is represented in WP3635. The model has been converted to GPML using the PathSBML plugin from PathVIsio, importing the model BIOMD0000000448 from the BioModels Database directly. The layout has been improved manually. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3634 CPTAC Assay Portal]
Authors
Anwesha Bohler , Kristina Hanspers , Andika Tan , Egon Willighagen , Ryan Miller , Chris Evelo , and Eric WeitzActivity
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Cited In
- Understanding signaling and metabolic paths using semantified and harmonized information about biological interactions (2022).
- Identification of candidate genes and pathways in retinopathy of prematurity by whole exome sequencing of preterm infants enriched in phenotypic extremes (2021).
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Organisms
Homo sapiensCommunities
Annotations
Cell Type Ontology
fat cellPathway Ontology
insulin signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| X | Metabolite | chebi:36080 | inactive feedback protein |
| X | Metabolite | kegg.compound:C00562 | active feedback protein |
| insulin | Metabolite | chebi:5931 | |
| P | Metabolite | chebi:28659 | |
| AS160p | GeneProduct | pato:PATO:0002220 | |
| AS160 | Protein | uniprot:O60343 | |
| GLUT4 | Protein | uniprot:P14672 | |
| GLUT4m | Protein | uniprot:P14672 | |
| INSR | Protein | uniprot:P06213 | Inactive, plasma membrane |
| IRS1 | Protein | uniprot:P35568 | |
| IRS1307 | Protein | uniprot:P35568 | |
| IRS1p | Protein | uniprot:P35568 | |
| IRS1p307 | Protein | uniprot:P35568 | |
| INSR | Protein | uniprot:P06213 | Inactive, internalized |
| INSR | Protein | uniprot:P06213 | insulin bound |
| INSR | Protein | uniprot:P06213 | internalized and tyrosine phosphorylated |
| INSR | Protein | uniprot:P06213 | Tyrosine phosphorylated |
| PKB | Protein | uniprot:P31751 | |
| PKB308p | Protein | uniprot:P31751 | |
| PKB308p473p | Protein | uniprot:P31751 | |
| PKB473p | Protein | uniprot:P31751 | |
| S6 | Protein | uniprot:P62753 | |
| S6K | Protein | uniprot:P23443 | |
| S6Kp | Protein | uniprot:P23443 | |
| S6p | Protein | uniprot:P62753 | |
| mTORC1 | Protein | uniprot:P42345 | |
| mTORC1a | Protein | uniprot:P42345 | |
| mTORC2 | Protein | uniprot:P42345 | |
| mTORC2a | Protein | uniprot:P42345 |
References
- Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes. Brännmark C, Nyman E, Fagerholm S, Bergenholm L, Ekstrand EM, Cedersund G, et al. J Biol Chem. 2013 Apr 5;288(14):9867–80. PubMed Europe PMC Scholia