Photodynamic therapy-induced unfolded protein response (WP3613)

Homo sapiens

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Photodynamic therapy may induce a proteotoxic stress response mediated by transcription factors heat shock factor 1 (HSF1), X-box binding protein 1 (XBP1), activating transcription factor (ATF) 6, and ATF4. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3613 CPTAC Assay Portal]

Authors

Ruud Weijer , Kristina Hanspers , Friederike Ehrhart , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

altered regulatory pathway

Disease Ontology

cancer

Participants
Query Drugst.One

Label Type Compact URI Comment
UBE2E1 GeneProduct ncbigene:7324
DNAJB9 GeneProduct ncbigene:4189
XBP1 GeneProduct ncbigene:7494
PDIA6 GeneProduct ncbigene:10130
EDEM1 GeneProduct ncbigene:9695
NFE2L2 GeneProduct ncbigene:4780
ATF4 GeneProduct ncbigene:468
EIF2A GeneProduct ncbigene:83939
ATF6 GeneProduct ncbigene:22926
HSPA5 GeneProduct ncbigene:3309
ERN1 GeneProduct ncbigene:2081
EIF2AK3 GeneProduct ncbigene:9451
HSP90B1 GeneProduct ncbigene:7184
ERP27 GeneProduct ncbigene:121506
CALR GeneProduct ncbigene:811
DDIT3 GeneProduct ncbigene:1649
DNAJC3 GeneProduct ncbigene:5611
ASNS GeneProduct ncbigene:440
DNAJB11 GeneProduct ncbigene:51726
SULT1E1 GeneProduct ncbigene:6783
NARS GeneProduct ncbigene:4677
ATF3 GeneProduct ncbigene:467
BBC3 GeneProduct ncbigene:27113
PPP1R15A GeneProduct ncbigene:23645
BCL2L11 GeneProduct ncbigene:10018
TRIB3 GeneProduct ncbigene:57761
WARS GeneProduct ncbigene:7453

References

  1. Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies. Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M. Cancer Metastasis Rev. 2015 Dec;34(4):643–90. PubMed Europe PMC Scholia
  2. Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells. Weijer R, Broekgaarden M, van Golen RF, Bulle E, Nieuwenhuis E, Jongejan A, et al. BMC Cancer. 2015 Dec 26;15:1014. PubMed Europe PMC Scholia