G1 to S cell cycle control (WP348)
Rattus norvegicus
In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&
Authors
Alexander C. Zambon , Kristina Hanspers , Christine Chichester , and Martina Summer-KutmonActivity
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Cited In
- Unraveling the blood transcriptome after real-life exposure of Wistar-rats to PM2.5, PM1 and water-soluble metals in the ambient air (2020).
- Microarray analyses reveal novel targets of exercise-induced stress resistance in the dorsal raphe nucleus (2013).
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Organisms
Rattus norvegicusCommunities
Annotations
Pathway Ontology
G1/S DNA damage checkpoint pathway cell cycle checkpoint pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Rb1 | GeneProduct | ensembl:ENSRNOG00000016029 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5925 |
| E2f2 | GeneProduct | ensembl:ENSRNOG00000047741 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1870 |
| E2f1 | GeneProduct | ensembl:ENSRNOG00000016708 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1869 |
| Pole | GeneProduct | ensembl:ENSRNOG00000037449 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5426 |
| Cdkn1b | GeneProduct | ensembl:ENSRNOG00000007249 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1027 |
| Cdk6 | GeneProduct | ensembl:ENSRNOG00000009258 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1021 |
| Pcna | GeneProduct | ensembl:ENSRNOG00000021264 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5111 |
| Cdk4 | GeneProduct | ensembl:ENSRNOG00000025602 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1019 |
| Cdkn1a | GeneProduct | ensembl:ENSRNOG00000000521 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1026 |
| Cdc45 | GeneProduct | ensembl:ENSRNOG00000050071 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8318 |
| Cdk1 | GeneProduct | ensembl:ENSRNOG00000000632 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:983 |
| Tp53 | GeneProduct | ensembl:ENSRNOG00000010756 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7157 |
| Prim2 | GeneProduct | ensembl:ENSRNOG00000012486 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5558 |
| Cdkn1c | GeneProduct | ensembl:ENSRNOG00000059500 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1028 |
| Ccnd2 | GeneProduct | ensembl:ENSRNOG00000057710 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:894 |
| E2f5 | GeneProduct | ensembl:ENSRNOG00000010760 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1875 |
| Ccne1 | GeneProduct | ensembl:ENSRNOG00000014786 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:898 |
| Creb3l4 | GeneProduct | ensembl:ENSRNOG00000023493 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:148327 |
| Cdkn2b | GeneProduct | ensembl:ENSRNOG00000006735 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1030 |
| Mdm2 | GeneProduct | ensembl:ENSRNOG00000006304 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4193 |
| Cdk7 | GeneProduct | ensembl:ENSRNOG00000018510 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1022 |
| Ccng2 | GeneProduct | ensembl:ENSRNOG00000002089 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:901 |
| Rpa2 | GeneProduct | ensembl:ENSRNOG00000013005 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6118 |
| Cdk2 | GeneProduct | ensembl:ENSRNOG00000006469 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1017 |
| E2f4 | GeneProduct | ensembl:ENSRNOG00000015708 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1874 |
| Creb3 | GeneProduct | ensembl:ENSRNOG00000016452 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10488 |
| Creb3l3 | GeneProduct | ensembl:ENSRNOG00000032202 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:84699 |
| Myt1 | GeneProduct | ensembl:ENSRNOG00000017346 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4661 |
| Tfdp2 | GeneProduct | ensembl:ENSRNOG00000011241 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7029 |
| Ccnb1 | GeneProduct | ensembl:ENSRNOG00000058539 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:891 |
| Ccnd3 | GeneProduct | ensembl:ENSRNOG00000050258 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:896 |
| Ccnd1 | GeneProduct | ensembl:ENSRNOG00000020918 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:595 |
| Ccnh | GeneProduct | ensembl:ENSRNOG00000031656 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:902 |
| Myc | GeneProduct | ensembl:ENSRNOG00000004500 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4609 |
| LOC100362927 | GeneProduct | ensembl:ENSRNOG00000037481 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6119 |
| Mcm4 | GeneProduct | ensembl:ENSRNOG00000001833 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4173 |
| Mcm3 | GeneProduct | ensembl:ENSRNOG00000012543 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4172 |
| Atf6b | GeneProduct | ensembl:ENSRNOG00000000431 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1388 |
| Orc1 | GeneProduct | ensembl:ENSRNOG00000008841 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4998 |
| Mcm6 | GeneProduct | ensembl:ENSRNOG00000003703 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4175 |
| Mcm7 | GeneProduct | ensembl:ENSRNOG00000001349 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4176 |
| Mcm2 | GeneProduct | ensembl:ENSRNOG00000016316 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4171 |
| Orc3 | GeneProduct | ensembl:ENSRNOG00000008314 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23595 |
| Cdkn2c | GeneProduct | ensembl:ENSRNOG00000008956 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1031 |
| Pole2 | GeneProduct | ensembl:ENSRNOG00000004242 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5427 |
| Mnat1 | GeneProduct | ensembl:ENSRNOG00000007267 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4331 |
| Orc6 | GeneProduct | ensembl:ENSRNOG00000024043 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23594 |
| Mcm5 | GeneProduct | ensembl:ENSRNOG00000014336 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4174 |
| E2f6 | GeneProduct | ensembl:ENSRNOG00000004449 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1876 |
| Orc2 | GeneProduct | ensembl:ENSRNOG00000012558 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4999 |
| E2f3 | GeneProduct | ensembl:ENSRNOG00000029273 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1871 |
| Tfdp1 | GeneProduct | ensembl:ENSRNOG00000019222 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7027 |
| Rpa1 | GeneProduct | ensembl:ENSRNOG00000003123 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6117 |
| Creb1 | GeneProduct | ensembl:ENSRNOG00000013412 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1385 |
| Rbl1 | GeneProduct | ensembl:ENSRNOG00000006921 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5933 |
| Wee1 | GeneProduct | ensembl:ENSRNOG00000010017 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7465 |
| Atm | GeneProduct | ensembl:ENSRNOG00000029773 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:472 |
| Creb3l1 | GeneProduct | ensembl:ENSRNOG00000005413 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:90993 |
| Gadd45a | GeneProduct | ensembl:ENSRNOG00000005615 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1647 |
| Pola2 | GeneProduct | ensembl:ENSRNOG00000020906 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23649 |
| Orc4 | GeneProduct | ensembl:ENSRNOG00000005021 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5000 |
| Prim1 | GeneProduct | ensembl:ENSRNOG00000031993 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5557 |
| Cdc25a | GeneProduct | ensembl:ENSRNOG00000020737 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:993 |
| Ccna1 | GeneProduct | ensembl:ENSRNOG00000014052 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8900 |
| Orc5 | GeneProduct | ensembl:ENSRNOG00000011519 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5001 |
| Ccne2 | GeneProduct | ensembl:ENSRNOG00000008055 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9134 |
References
- GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA. J Invest Dermatol. 2002 Jul;119(1):22–6. PubMed Europe PMC Scholia