Serotonin transporter activity (WP3138)

Bos taurus

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Serotonin is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract (GI tract), blood platelets, and the central nervous system (CNS) of animals, including humans. It is popularly thought to be a contributor to feelings of well-being and happiness. This pathway summarizes the role of the antidepressant-sensitive serotonin (5-HT) transporter SERT (encoded by the SLC6A4 gene).

Authors

Martina Summer-Kutmon , Linda Rieswijk , Egon Willighagen , Eric Weitz , Alex Pico , and Denise Slenter

Activity

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Organisms

Bos taurus

Communities

Annotations

Cell Type Ontology

neuron

Pathway Ontology

serotonin signaling pathway

Participants

Label Type Compact URI Comment
Serotonin Metabolite hmdb:HMDB0000259
L-Tryptophan Metabolite hmdb:HMDB0000929
Citalopram Metabolite hmdb:HMDB0005038
SCAMP2 GeneProduct ensembl:ENSBTAG00000005844 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10066
TGFB1I1 GeneProduct ensembl:ENSBTAG00000002391 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7041
SLC6A4 GeneProduct ensembl:ENSBTAG00000019349 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6532
INTB3 GeneProduct ensembl:ENSBTAG00000009987 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3690
IL1B GeneProduct ensembl:ENSBTAG00000001321 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
PPP2CB GeneProduct ensembl:ENSBTAG00000009245 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5516
STX1A GeneProduct ensembl:ENSBTAG00000017075 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6804
MAOA GeneProduct ensembl:ENSBTAG00000016206 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4128
NOS1 GeneProduct ensembl:ENSBTAG00000002023 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4842
TPH2 GeneProduct ensembl:ENSBTAG00000020792 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:121278
IL1R1 GeneProduct ensembl:ENSBTAG00000005273 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3554

References

  1. Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter. Carneiro AMD, Blakely RD. J Biol Chem. 2006 Aug 25;281(34):24769–80. PubMed Europe PMC Scholia
  2. Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Chanrion B, Mannoury la Cour C, Bertaso F, Lerner-Natoli M, Freissmuth M, Millan MJ, et al. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8119–24. PubMed Europe PMC Scholia
  3. Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. Carneiro AMD, Cook EH, Murphy DL, Blakely RD. J Clin Invest. 2008 Apr;118(4):1544–52. PubMed Europe PMC Scholia